Results 31 to 40 of about 216,413 (307)

The pharmacogenomics of statins

Pharmacological Research, 2014
The statin class of cholesterol-lowering drugs have been used for decades to successfully lower plasma cholesterol concentrations and cardiovascular risk. Adverse effects of statins are generally considered mild, but increase with age of patients and polypharmacy.
Ingrid C, Gelissen, Andrew J, McLachlan
openaire   +2 more sources

Statin use after acute myocardial infarction by patient complexity: Are the rates right? [PDF]

, 2015
Reprinted with permission of the publisher.Background: Guidelines suggest statin use after acute myocardial infarction (AMI) should be close to universal in patients without safety concerns yet rates are much lower than recommended, decline with patient ...
Abd, Baigent, Baigent, Braunwald, Braunwald, Brooks, Brooks, Brooks, Collins, Cziraky, Fang, Fang, Florentin, Golomb, Grabowski, Harris, Heart Protection Study Collaborative, Hippisley-Cox, Javed, Kjekshus, Klabunde, Law, Lewis, Mansi, McClellan, Park, Robinson, Shepherd, Smith, Steg, Tavazzi, Van de Werf, Van de Werf, Wennberg, Yan, Zhang, Zuckerman   +36 more
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Statins: Then and Now

Methodist DeBakey Cardiovascular Journal, 2019
The discovery of statins (3-hydroxy-3-methylglutaryl CoA reductase inhibitors) is a consequence of the highly targeted, arduous search for naturally occurring compounds that inhibit cholesterol biosynthesis. An enormous amount of basic scientific, genetic, and clinical research substantiated the role of lipoprotein-derived cholesterol in atherogenesis.
Peter P, Toth, Maciej, Banach
openaire   +2 more sources

Statins attenuate cholesterol-induced ROS via inhibiting NOX2/NOX4 and mitochondrial pathway in collecting ducts of the kidney

BMC Nephrology, 2022
Background Statins therapy has been primarily recommended for the prevention of cardiovascular risk in patients with chronic kidney diseases. Statins has also been proved some benefits in lipid-induced kidney diseases.
Ani Wang, Yu Lin, Baien Liang, Xiaoduo Zhao, Miaojuan Qiu, Hui Huang, Chunling Li, Weidong Wang, Yonglun Kong   +8 more
doaj   +1 more source

New insights into the therapeutic potentials of statins in cancer

Frontiers in Pharmacology, 2023
The widespread clinical use of statins has contributed to significant reductions of cardiovascular morbidity and mortality. Increasing preclinical and epidemiological evidences have revealed that dyslipidemia is an important risk factor for ...
Chengyu Liu, Hong Chen, Bicheng Hu, Jiajian Shi, Yuchen Chen, Kun Huang, Kun Huang   +6 more
doaj   +1 more source

Utility of 2013 American College of Cardiology/American Heart Association Cholesterol Guidelines in HIV-Infected Adults With Carotid Atherosclerosis. [PDF]

, 2017
BackgroundAlthough HIV is associated with increased atherosclerotic cardiovascular disease (CVD) risk, it is unknown whether guidelines can identify HIV-infected adults who may benefit from statins.
Deeks, Steven, Hsue, Priscilla, Hur, Sophia, Kalapus, SC, Li, Danny, Ma, Yifei, Phan, Binh An P, Scherzer, Rebecca, Weigel, Bernard   +8 more
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A retrospective study on the effect of statins on mortality and antimicrobial resistance among patients with Staphylococcus aureus bloodstream infection

Archives of Medical Science
Introduction There is insufficient evidence in statin on the treatment of Staphylococcus aureus (SA) infection, we observe and analyze the clinical outcomes and antibiotic resistance of SA bloodstream infections in patients who received statins ...
Jianwei Su, Yixuan Wang, Wanping Zhong, Mengzhi Wang, Yanhong Wang   +4 more
doaj   +1 more source

Future of Statins in Sepsis: A Review on Its Safety and Efficacy

Archives of Pharmaceutical Sciences Ain Shams University, 2020
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Statins [Hydroxymethylglutaryl-CoA reductase inhibitors] not only lower cholesterol levels but also have been proposed as adjunctive therapy in sepsis due
Sara Eladwy, Naglaa Bazan
doaj   +1 more source

Statins for primary and secondary prevention in the oldest old : an overview of the existing evidence [PDF]

, 2012
Hypercholesterolemia, although a modifiable risk factor for cardiovascular disease, is still one of the leading causes of death among older people in western countries.
Petrovic, Mirko, Van Den Noortgate, Nele, WERBROUCK, BART   +2 more
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Targeting inflammation to reduce cardiovascular disease risk: a realistic clinical prospect? [PDF]

, 2017
Data from basic science experiments is overwhelmingly supportive of the causal role of immune-inflammatory response(s) at the core of atherosclerosis, and therefore the theoretical potential to manipulate the inflammatory response to prevent ...
Abbas, Agca, Ait-Oufella, Albert, Alexander, Alexander, Alexander, Alexander, Andersen, Aziz, Babelova, Bellosta, Bevilacqua, Bhaskar, Blom, Boekholdt, Boekholdt, Bostrom, Brånén, Bulgarelli, Bulgarelli, Burke, Cai, Cannon, Casas, Collins, Cronstein, Dahlman-Ghozlan, Danesh, Davenport, Davey Smith, Davidson, DeOliveira, Devlin, Dinarello, Duewell, Duivenvoorden, Eisenhardt, Elango, Elhage, Ettehad, Flood, Fraser, Freigang, Fulgoni, Galkina, Galkina, Garlanda, Grassia, Grassia, Greenberg, Hansson, Hauer, Herder, Holmes, Hu, Huang, Huber, Interleukin 1 Genetics Consortium, Ivandic, Kalliolias, Kaptoge, Kimura, Kinlay, Kirii, Kleinman, Koltsova, Kureishi, Kwak, Lee, Leite, Leite, Lewington, Liao, Libby, Libby, Macritchie, Maddaluno, Maeda, Maffia, Makheja, Margaritis, McInnes, Menu, Micha, Mihaylova, Mira, Mohler, Montezano, Mulhaupt, Murad, Myasoedova, Myung, Nakata, Nicholls, O'Donoghue, Ogdie, Ohta, Pauling, Peters, Qiao, Quarck, Rajamäki, Rastogi, Reiss, Rezaie-Majd, Ridker, Ridker, Rincón, Robertson, Romano, Rosenson, Rosenson, Roubille, Ryan, Rössig, Saeed, Sage, Sarwar, Sattar, Scalia, Schett, Schieffer, Schuett, Serruys, Sever, Sever, Shah, Shaposhnik, Singh, Sirtori, Sniderman, Soedamah-Muthu, Solomon, Southan, Souverein, Sprague, Srikakulapu, Strober, Sukovich, Swerdlow, Swirski, Talmud, Tay, Teng, Thompson, Tits, Toedter, Turunen, Tzellos, Walker, Wang, Wang, Watson, Weintraub, Welsh, Welsh, Welsh, Welsh, Weng, Wensley, White, Wilensky, Willeit, Willis, Wong, Woodward, Xanthoulea, Ye, Ye, Yilmaz, Youssef, Zalewski, Zhao   +173 more
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