Results 31 to 40 of about 150,085 (313)

Effect of statins on venous thromboembolic events: a meta-analysis of published and unpublished evidence from randomised controlled trials [PDF]

, 2012
Background - It has been suggested that statins substantially reduce the risk of venous thromboembolic events. We sought to test this hypothesis by performing a meta-analysis of both published and unpublished results from randomised trials of statins.
Jacquet Hervet, Michel, Pieter Kamphuisen, Wikstrand John, Bhala, Neeraj, Haluska, B. A., Sara Biere-Rafi (135090), Kostner, K., Emberson, J, Hegney, D., Pieter Kamphuisen (135078), Bolte, J., McMurray, J.J.V., Delhaas, T., Holliday, J., Wikstrand, J, Glasziou, P. P., Hall, A. S., Samani, N. J., Emberson, J., Carrington, M. J., Blankenberg, S., Reino Maceiras, Maria Victoria, Ling, H. L., Álvarez Álvarez, Belén, Alvarez Castro, Ezequiel, Michele Robertson (135100), Sara Biere-Rafi, Agra Bermejo, Rosa Maria, McMurray, John, Kazem Rahimi (135073), Kamphuisen, P., Frueh, M., Kamphuisen, Pieter, McMurray, J., Schute, F., McMurray John, Biere-Rafi, Sara, Reha-Sleep-Registry, Paradela Dobarro, Beatriz, García Acuña, José María, Janousek, J., Robertson, Michele, Wikstrand, John, Abuassi, Emad, Robertson, M., Kamphuisen, P, Kamke, W., Robertson Michele, Michele Robertson, Zeller, T., Biere-Rafi Sara, Stewart, S., McMurray, J, Peña Gil, Carlos, Rodiño Janeiro, Bruno K, Musameh, M. D., John McMurray, Wang, W. Y. S., Emberson Jonathan, S. Caravita, A. Faini, Neeraj Bhala (135075), John Wikstrand, John McMurray (135109), Keech, A. C., Vera Krane (135094), Jonathan Emberson, Van Geldorp, I., Jonathan Emberson (135084), Rahimi, Kazem, Tonkin, A. M., Elders, J., Rahimi, K, Schroeder, K., S. Salerno, Krane Vera, Krane, V, Vera Krane, Sullivan, D. R., Wikstrand, John,, Bhala, N., Prinzen, F. W., Nelson, C. P., E. Lisi, Krane, V., Biere-Rafi, S., Alt, B., Neeraj Bhala, Skobel, E., Grigorian Shamagian, Lilian, Ball, S. G., G. Parati, Biere-Rafi, S, Kazem Rahimi, ?, ?, Balmforth, A. J., Tomaszewski, M., M. Valentini, John Wikstrand (135105), White, H. D., Carrington, M., Schwaab, B., Rosenthal, E., Raposeiras Roubín, Sergio, Gestal Romani, Santiago, Bhala Neeraj, Cabanas Grandio, Maria Pilar, Emberson, Jonathan, Woehrle, H., Kamphuisen Pieter, Espinoza, D., Tomaske, M., Bhala, N, Hague, W., Rahimi Kazem, G. Bilo, Krane, Vera, P. Agostoni, Rahimi, K., Haluska, B., Krupickova, S., González Juanatey, José Ramón, González Cambeiro, María Cristina, Marwick, T. H., Wikstrand, J., Hiippala, A., Pereira Lopez, Eva Maria, Aguiar Souto, Pablo, Purucker, H. C., Boenner, G., Krüger, S., M. Revera, Simes, R. J., C. Lombardi, Robertson, M   +134 more
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Effect of statins on post-contrast acute kidney injury: a multicenter retrospective observational study

Lipids in Health and Disease, 2021
Background Post-contrast acute kidney injury (PC-AKI) is a severe complication of coronary angiography (CAG) and percutaneous coronary intervention (PCI). Currently, the effect of statins on PC-AKI and its mechanism remains unclear.
Maoning Lin, Tian Xu, Wenjuan Zhang, Duannbin Li, Ya Li, Xulin Hong, Yi Luan, Wenbin Zhang, Min Wang   +8 more
doaj   +1 more source

Statin therapy in critical illness : an international survey of intensive care physicians' opinions, attitudes and practice [PDF]

, 2012
Background Pleotropic effects of statins on inflammation are hypothesised to attenuate the severity of and possibly prevent the occurrence of the host inflammatory response to pathogen and infection-related acute organ failure.
Kruger, Peter S., Damon C Scales, Stefania Di Gangi, Danny F McAuley, Scales, Damon C., McAuley, Danny F., Terblanche, Marius, Perkins, Gavin D., Di Gangi, Stefania, Gavin D Perkins, Manu Shankar-Hari, Scales, Damon C, Perkins, Gavin D, Kruger, Peter S, Marius Terblanche, Peter S Kruger, Shankar-Hari, Manu, Scales, DamonC., McAuley, Danny F   +18 more
core   +1 more source

Heterologous expression of MlcE in Saccharomyces cerevisiae provides resistance to natural and semi-synthetic statins

Metabolic Engineering Communications, 2015
Statins are inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase, the key enzyme in cholesterol biosynthesis. Their extensive use in treatment and prevention of cardiovascular diseases placed statins among the best selling drugs. Construction of
Ana Ley, Hilde Cornelijne Coumou, Rasmus John Normand Frandsen   +2 more
doaj   +1 more source

Prospects for the use of statins in antiviral therapy [PDF]

Клиническая микробиология и антимикробная химиотерапия, 2023
Inhibitors of hydroxymethylglutaryl-CoA reductase, in addition to suppressing cholesterol synthesis, have an antiviral effect. Clinical studies have shown antiviral efficacy of statins against COVID-19, HCV, HBV, RSV, HIV, influenza viruses.
Mustafin R.N.
doaj   +1 more source

The pharmacogenomics of statins

Pharmacological Research, 2014
The statin class of cholesterol-lowering drugs have been used for decades to successfully lower plasma cholesterol concentrations and cardiovascular risk. Adverse effects of statins are generally considered mild, but increase with age of patients and polypharmacy.
Ingrid C, Gelissen, Andrew J, McLachlan
openaire   +2 more sources

The role of statins in prevention and treatment of community acquired pneumonia: a systematic review and meta-analysis.

, 2013
BACKGROUND: Emerging epidemiological evidence suggests that statins may reduce the risk of community-acquired pneumonia (CAP) and its complications. PURPOSE: Performed a systematic review to address the role of statins in the prevention or treatment ...
Imad M Tleyjeh, Khan Abdur Rahman, Mohamad A. Al-Tannir (104241), Imad M. Tleyjeh (104252), Tleyjeh, I. M., Patricia J Erwin, Muhammad Riaz, Abdur Rahman Khan (104234), Garbati, MA, Muhammad Riaz (104236), Bin Abdulhak, AA, Bin Abdulhak Aref A., Erwin, PJ, Baddour, LM, Riaz Muhammad, Musa A Garbati, Aref A. Bin Abdulhak (5648656), Patricia J. Erwin (104246), Abdur Rahman Khan, Al-Tannir Mohamad A., Riaz, M., Khan, AR, Al-Tannir, MA, Tleyjeh, IM, Erwin Patricia J., Larry M Baddour, Baddour Larry M., Khan, A. R., Garbati, M. A., Garbati Musa A., Al-Tannir, M. A., Larry M. Baddour (104249), Riaz, M, Aref A Bin Abdulhak, Mohamad A Al-Tannir, Bin Abdulhak, A. A., Tleyjeh Imad M., Erwin, P. J., Baddour, L. M., Musa A. Garbati (104244)   +39 more
core   +1 more source

Statins: Then and Now

Methodist DeBakey Cardiovascular Journal, 2019
The discovery of statins (3-hydroxy-3-methylglutaryl CoA reductase inhibitors) is a consequence of the highly targeted, arduous search for naturally occurring compounds that inhibit cholesterol biosynthesis. An enormous amount of basic scientific, genetic, and clinical research substantiated the role of lipoprotein-derived cholesterol in atherogenesis.
Peter P, Toth, Maciej, Banach
openaire   +2 more sources

Prevalence and types of persistent dyslipidemia in patients treated with statins

, 2013
Aim To determine the prevalence and types of persistent dyslipidemia in patients treated with different statins to reduce cardiovascular disease (CVD) risk, as well as to determine the proportion of high risk patients who did not reach the lipid ...
Željko Reiner, Reiner, Željko, Eugenia Tedeschi-Reiner, Tedeschi-Reiner, Eugenia   +3 more
core   +1 more source

Lovastatin for adult patients with dengue: protocol for a randomised controlled trial. [PDF]

, 2012
BACKGROUND: Dengue is the most important vector-borne viral infection of man, with approximately 2 billion people living in areas at risk. Infection results in a range of manifestations from asymptomatic infection through to life-threatening shock and ...
Hien, TT, Hien, Tran Tinh, Simmons, Cameron, Simmons, C, Nguyen Van Hao, Tai, Luong Thi Hue, Marcel Wolbers, Wills, B, Truong, Nguyen Thanh, James Whitehorn, Rosanna Peeling, Peeling, Rosanna, Tai, LT, Nguyen Thanh Truong, Dung, NT, Tran Tinh Hien, Laura Merson, Nguyen Thi Phuong Dung, Wills, Bridget, Nguyen Van Vinh Chau, Whitehorn, J, Cameron Simmons, Wolbers, Marcel, Bridget Wills, Van Hao, N, Farrar, J, Farrar, Jeremy, Peeling, R, Jeremy Farrar, Van Vinh Chau, Nguyen, Whitehorn, James, Merson, Laura, Truong, NT, Hien, Tran, Van Vinh Chau, N, Van Hao, Nguyen, Wolbers, M, Hien, T, Luong Thi Hue Tai, Dung, Nguyen Thi Phuong, Merson, L   +40 more
core   +1 more source