Results 11 to 20 of about 124,347 (217)

Attempts to use statins in cancer therapy: An update

Tumor Biology, 2020
Although it could be speculated that almost everything has been said concerning the use of statins in cancer therapy, statins as anticancer drugs have both committed supporters and opponents, for whom the dispute about the legitimacy of statin use in ...
Lucyna Matusewicz, Aleksander Czogalla, Aleksander F Sikorski   +2 more
doaj   +1 more source

The pharmacological bases for repurposing statins in depression: a review of mechanistic studies

Translational Psychiatry, 2023
Statins are commonly prescribed medications widely investigated for their potential actions on the brain and mental health. Pre-clinical and clinical evidence suggests that statins may play a role in the treatment of depressive disorders, but only the ...
Riccardo De Giorgi, Nicola Rizzo Pesci, Gianluca Rosso, Giuseppe Maina, Philip J. Cowen, Catherine J. Harmer   +5 more
doaj   +1 more source

Statins utilization trends and expenditures in the U.S. before and after the implementation of the 2013 ACC/AHA guidelines

Saudi Pharmaceutical Journal, 2023
Importance: Statins are drugs of choice in treating hyperlipidemia and preventing or reducing cardiovascular diseases. Purpose: Explore statins utilization and expenditure trends in the United States before and after the publication of the 2013 ACC/AHA ...
Amro Matyori, Clyde P. Brown, Askal Ali, Fatimah Sherbeny   +3 more
doaj   +1 more source

Statin Hepatotoxicity: Is it a Real Concern?

Heart Views, 2011
Statins are the most effective and widely used drugs for treating dyslipidemia, a major risk factor for coronary heart disease. These are one of the safest hypolipidemic drugs but many patients are advised to discontinue statins for the fear of ...
Pranav Sikka, K K Saxena, Seema Kapoor
doaj   +1 more source

Effect of statins on post-contrast acute kidney injury: a multicenter retrospective observational study

Lipids in Health and Disease, 2021
Background Post-contrast acute kidney injury (PC-AKI) is a severe complication of coronary angiography (CAG) and percutaneous coronary intervention (PCI). Currently, the effect of statins on PC-AKI and its mechanism remains unclear.
Maoning Lin, Tian Xu, Wenjuan Zhang, Duannbin Li, Ya Li, Xulin Hong, Yi Luan, Wenbin Zhang, Min Wang   +8 more
doaj   +1 more source

Heterologous expression of MlcE in Saccharomyces cerevisiae provides resistance to natural and semi-synthetic statins

Metabolic Engineering Communications, 2015
Statins are inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase, the key enzyme in cholesterol biosynthesis. Their extensive use in treatment and prevention of cardiovascular diseases placed statins among the best selling drugs. Construction of
Ana Ley, Hilde Cornelijne Coumou, Rasmus John Normand Frandsen   +2 more
doaj   +1 more source

Efficacy of statin treatment based on cardiovascular outcomes in elderly patients: a standard meta-analysis and Bayesian network analysis

Journal of International Medical Research, 2020
Objective Statins have been shown to be beneficial for the prevention of cardiovascular events. In elderly individuals, the efficacy of statins remains controversial and the comparative effect of statins has not been assessed.
Chuannan Zhai, Kai Hou, Rui Li, YueCheng Hu, JingXia Zhang, YingYi Zhang, Le Wang, Rui Zhang, HongLiang Cong   +8 more
doaj   +1 more source

Prospects for the use of statins in antiviral therapy [PDF]

Клиническая микробиология и антимикробная химиотерапия, 2023
Inhibitors of hydroxymethylglutaryl-CoA reductase, in addition to suppressing cholesterol synthesis, have an antiviral effect. Clinical studies have shown antiviral efficacy of statins against COVID-19, HCV, HBV, RSV, HIV, influenza viruses.
Mustafin R.N.
doaj   +1 more source

Statin-induced apoptosis via the suppression of ERK1/2 and Akt activation by inhibition of the geranylgeranyl-pyrophosphate biosynthesis in glioblastoma

Journal of Experimental & Clinical Cancer Research, 2011
Background Statins are inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, the rate-limiting enzyme in cholesterol synthesis. The inhibition of this key enzyme in the mevalonate pathway leads to suppression of cell proliferation and induction ...
Itoh Tatsuki, Satou Takao, Tsubaki Masanobu, Yanae Masashi, Imano Motohiro, Yamazoe Yuzuru, Nishida Shozo   +6 more
doaj   +1 more source

Lipophilic vs. hydrophilic statins and psychiatric hospitalizations and emergency room visits in US Veterans with schizophrenia and bipolar disorder

Pteridines, 2021
Psychiatric hospitalizations and emergency department (ED) visits are costly, stigmatizing, and often ineffective. Given the immune and kynurenine activation in bipolar disorder (BD) and schizophrenia, as well as the immune-modulatory effects of statins,
Postolache Teodor T., Medoff Deborah R., Brown Clayton H., Fang Li Juan, Upadhyaya Sanjaya K., Lowry Christopher A., Miller Michael, Kreyenbuhl Julie A.   +7 more
doaj   +1 more source