Results 41 to 50 of about 150,085 (313)

Statins interfere with the attachment of S. cerevisiae mtDNA to the inner mitochondrial membrane

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
The 3-hydroxy-3-methylglutaryl-CoA reductase, a key enzyme of the mevalonate pathway for the synthesis of cholesterol in mammals (ergosterol in fungi), is inhibited by statins, a class of cholesterol lowering drugs.
Angela Cirigliano, Antonia Amelina, Beatrice Biferali, Alberto Macone, Chiara Mozzetta, Michele Maria Bianchi, Mattia Mori, Bruno Botta, Elah Pick, Rodolfo Negri, Teresa Rinaldi   +10 more
doaj   +1 more source

Statin-induced apoptosis via the suppression of ERK1/2 and Akt activation by inhibition of the geranylgeranyl-pyrophosphate biosynthesis in glioblastoma

Journal of Experimental & Clinical Cancer Research, 2011
Background Statins are inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, the rate-limiting enzyme in cholesterol synthesis. The inhibition of this key enzyme in the mevalonate pathway leads to suppression of cell proliferation and induction ...
Itoh Tatsuki, Satou Takao, Tsubaki Masanobu, Yanae Masashi, Imano Motohiro, Yamazoe Yuzuru, Nishida Shozo   +6 more
doaj   +1 more source

The Adverse Effects of Statins Therapy

, 2021
statins are one of the most important drugs used in the prevention of cardiovascular events. There benefits however does come without side effects, which can be serious and its important to have a knowlege on their management.
Dekkar, Reihana
core  

Secondary prevention of coronary heart disease in older patients after the national service framework: population based study [PDF]

, 2006
Objective To examine the extent of uptake of medication for secondary prevention of coronary heart disease in older British men and women before (1998-2001) and after (2003) the implementation of the national service framework.Design Two population based,
Morris, RW, Whincup, Peter H, Whincup, PH, Morris, Richard W, Papacosta, O, Ramsay, Sheena E, Ebrahim, S, Lawlor, Debbie A, Thomas, Mary C, Thomas, MC, Lennon, Lucy T, Lawlor, DA, Ramsay, SE, Lennon, LT, Ebrahim, Shah, Papacosta, Olia   +15 more
core   +1 more source

Lipophilic vs. hydrophilic statins and psychiatric hospitalizations and emergency room visits in US Veterans with schizophrenia and bipolar disorder

Pteridines, 2021
Psychiatric hospitalizations and emergency department (ED) visits are costly, stigmatizing, and often ineffective. Given the immune and kynurenine activation in bipolar disorder (BD) and schizophrenia, as well as the immune-modulatory effects of statins,
Postolache Teodor T., Medoff Deborah R., Brown Clayton H., Fang Li Juan, Upadhyaya Sanjaya K., Lowry Christopher A., Miller Michael, Kreyenbuhl Julie A.   +7 more
doaj   +1 more source

Efficacy and safety of statins, ezetimibe and statins-ezetimibe therapies for children and adolescents with heterozygous familial hypercholesterolaemia:Systematic review, pairwise and network meta-analyses of randomised controlled trials [PDF]

BACKGROUND AND AIMS: Statins, ezetimibe and statins-ezetimibe combination therapy are recommended lipid-lowering therapies (LLTs) in children with heterozygous familial hypercholesterolaemia (HeFH).
Tata, Laila J, Llewellyn, Alexis, Fisher, Mark, Woods, Beth, Priestley-Barnham, Lorraine, Tata, Laila J., Simmonds, Mark, Harden, Melissa, Marshall, David, Humphries, Steve E, Ramaswami, Uma, Qureshi, Nadeem, Humphries, Steve E.   +12 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

There is a slight increase in incident diabetes risk with the use of statins, but benefits likely outweigh any adverse effects in those with moderate-to-high cardiovascular risk

, 2010
Statins are one of the most widely used drug classes, with approximately 50 million prescriptions dispensed in England alone in 2008. Their efficacy and safety in significantly reducing cardiovascular events in moderate-to-high-risk patients has been ...
Bhatia, Lokpal, L. Bhatia, Byrne, Christopher D., C. D. Byrne   +3 more
core   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Statins attenuate cholesterol-induced ROS via inhibiting NOX2/NOX4 and mitochondrial pathway in collecting ducts of the kidney

BMC Nephrology, 2022
Background Statins therapy has been primarily recommended for the prevention of cardiovascular risk in patients with chronic kidney diseases. Statins has also been proved some benefits in lipid-induced kidney diseases.
Ani Wang, Yu Lin, Baien Liang, Xiaoduo Zhao, Miaojuan Qiu, Hui Huang, Chunling Li, Weidong Wang, Yonglun Kong   +8 more
doaj   +1 more source