Results 41 to 50 of about 254,908 (357)

Efficacy of statin treatment based on cardiovascular outcomes in elderly patients: a standard meta-analysis and Bayesian network analysis

Journal of International Medical Research, 2020
Objective Statins have been shown to be beneficial for the prevention of cardiovascular events. In elderly individuals, the efficacy of statins remains controversial and the comparative effect of statins has not been assessed.
Chuannan Zhai, Kai Hou, Rui Li, YueCheng Hu, JingXia Zhang, YingYi Zhang, Le Wang, Rui Zhang, HongLiang Cong   +8 more
doaj   +1 more source

Statin therapy in critical illness : an international survey of intensive care physicians' opinions, attitudes and practice [PDF]

, 2012
Background Pleotropic effects of statins on inflammation are hypothesised to attenuate the severity of and possibly prevent the occurrence of the host inflammatory response to pathogen and infection-related acute organ failure.
Kruger, Peter S., Damon C Scales, Stefania Di Gangi, Danny F McAuley, Scales, Damon C., McAuley, Danny F., Terblanche, Marius, Perkins, Gavin D., Di Gangi, Stefania, Gavin D Perkins, Manu Shankar-Hari, Scales, Damon C, Perkins, Gavin D, Kruger, Peter S, Marius Terblanche, Peter S Kruger, Shankar-Hari, Manu, Scales, DamonC., McAuley, Danny F   +18 more
core   +2 more sources

Statins as adjuvants [PDF]

Nature Reviews Immunology, 2018
Besides cholesterol lowering, statins boost antigen presentation and adaptive immune responses, suggesting new uses as adjuvants for cancer immunotherapy.
openaire   +2 more sources

Potential Benefits and Risks Associated with the Use of Statins

Pharmaceutics
HMG-CoA reductase inhibitors, commonly known as statins, are the primary treatment choice for cardiovascular diseases, which stand as the leading global cause of mortality.
Nisha Khatiwada, Zhongkui Hong
semanticscholar   +1 more source

Sex Differences in the Use of Statins in Community Practice: The Patient and Provider Assessment of Lipid Management (PALM) Registry

Circulation. Cardiovascular Quality and Outcomes, 2019
BACKGROUND Female patients have historically received less aggressive lipid management than male patients. Contemporary care patterns and the potential causes for these differences are unknown.
M. Nanna, Tracy Y. Wang, Qun Xiang, A. Goldberg, J. Robinson, V. Roger, S. Virani, P. Wilson, M. Louie, A. Koren, Zhuokai Li, E. Peterson, A. Navar   +12 more
semanticscholar   +1 more source

Lovastatin for adult patients with dengue: protocol for a randomised controlled trial. [PDF]

, 2012
BACKGROUND: Dengue is the most important vector-borne viral infection of man, with approximately 2 billion people living in areas at risk. Infection results in a range of manifestations from asymptomatic infection through to life-threatening shock and ...
Hien, TT, Hien, Tran Tinh, Simmons, Cameron, Simmons, C, Nguyen Van Hao, Tai, Luong Thi Hue, Marcel Wolbers, Wills, B, Truong, Nguyen Thanh, James Whitehorn, Rosanna Peeling, Peeling, Rosanna, Tai, LT, Nguyen Thanh Truong, Dung, NT, Tran Tinh Hien, Laura Merson, Nguyen Thi Phuong Dung, Wills, Bridget, Nguyen Van Vinh Chau, Whitehorn, J, Cameron Simmons, Wolbers, Marcel, Bridget Wills, Van Hao, N, Farrar, J, Farrar, Jeremy, Peeling, R, Jeremy Farrar, Van Vinh Chau, Nguyen, Whitehorn, James, Merson, Laura, Truong, NT, Hien, Tran, Van Vinh Chau, N, Van Hao, Nguyen, Wolbers, M, Hien, T, Luong Thi Hue Tai, Dung, Nguyen Thi Phuong, Merson, L   +40 more
core   +2 more sources

Statin-induced apoptosis via the suppression of ERK1/2 and Akt activation by inhibition of the geranylgeranyl-pyrophosphate biosynthesis in glioblastoma

Journal of Experimental & Clinical Cancer Research, 2011
Background Statins are inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, the rate-limiting enzyme in cholesterol synthesis. The inhibition of this key enzyme in the mevalonate pathway leads to suppression of cell proliferation and induction ...
Itoh Tatsuki, Satou Takao, Tsubaki Masanobu, Yanae Masashi, Imano Motohiro, Yamazoe Yuzuru, Nishida Shozo   +6 more
doaj   +1 more source

Lipophilic vs. hydrophilic statins and psychiatric hospitalizations and emergency room visits in US Veterans with schizophrenia and bipolar disorder

Pteridines, 2021
Psychiatric hospitalizations and emergency department (ED) visits are costly, stigmatizing, and often ineffective. Given the immune and kynurenine activation in bipolar disorder (BD) and schizophrenia, as well as the immune-modulatory effects of statins,
Postolache Teodor T., Medoff Deborah R., Brown Clayton H., Fang Li Juan, Upadhyaya Sanjaya K., Lowry Christopher A., Miller Michael, Kreyenbuhl Julie A.   +7 more
doaj   +1 more source

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

Efficacy and safety of statins, ezetimibe and statins-ezetimibe therapies for children and adolescents with heterozygous familial hypercholesterolaemia:Systematic review, pairwise and network meta-analyses of randomised controlled trials [PDF]

BACKGROUND AND AIMS: Statins, ezetimibe and statins-ezetimibe combination therapy are recommended lipid-lowering therapies (LLTs) in children with heterozygous familial hypercholesterolaemia (HeFH).
Tata, Laila J, Llewellyn, Alexis, Fisher, Mark, Woods, Beth, Priestley-Barnham, Lorraine, Tata, Laila J., Simmonds, Mark, Harden, Melissa, Marshall, David, Humphries, Steve E, Ramaswami, Uma, Qureshi, Nadeem, Humphries, Steve E.   +12 more
core   +1 more source