Results 51 to 60 of about 216,413 (307)

High dose atorvastatin associated with increased risk of significant hepatotoxicity in comparison to simvastatin in UK GPRD cohort [PDF]

, 2016
Background and Aims: Occasional risk of serious liver dysfunction and autoimmune hepatitis during atorvastatin therapy has been reported. We compared the risk of hepatotoxicity in atorvastatin relative to simvastatin treatment.
Clarke, Alan T., Ford, Ian, Hall, Gillian C., Johnson, Paul C.D., Mills, Peter   +4 more
core   +8 more sources

Conserved statin-mediated activation of the p38-MAPK pathway protects Caenorhabditis elegans from the cholesterol-independent effects of statins

Molecular Metabolism, 2020
Objective: Statins are a group of medications that reduce cholesterol synthesis by inhibiting the activity of HMG-CoA reductase, a key enzyme in the mevalonate pathway. The clinical use of statins to lower excess cholesterol levels has revolutionized the
Irina Langier Goncalves, Sharon Tal, Liza Barki-Harrington, Amir Sapir   +3 more
doaj   +1 more source

Rheumatoid Arthritis and Coronary Artery Calcium Progression: A Case Cohort Analysis from ELSA‐Brasil

Arthritis Care &Research, Accepted Article.
Objective To investigate the association between rheumatoid arthritis (RA) and coronary artery calcium (CAC) prevalence, incidence, and progression over four years in adults without prior cardiovascular disease. Methods A case‐cohort study within ELSA‐Brasil included 585 participants (86 RA, 499 controls). Longitudinal analyses were restricted to those
Patrícia Fonseca Estrada, Marcos R. N. Cavalcante, Itamar de Souza Santos, Márcio S. Bittencourt, Vandrize Meneghini, Paulo Andrade Lotufo, Alessandra C.Goulart, Isabela M. Bensenor   +7 more
wiley   +1 more source

Differential and Joint Effects of Metformin and Statins on Overall Survival of Elderly Patients with Pancreatic Adenocarcinoma: A Large Population-Based Study. [PDF]

, 2017
Background: Published evidence indicates that individual use of metformin and statin is associated with reduced cancer mortality. However, their differential and joint effects on pancreatic cancer survival are inconclusive.Methods: We identified a large ...
Demissie, Kitaw, E, Jian-Yu, Graber, Judith M., Lin, Yong, Lu, Shou-En, Lu-Yao, Grace, Petersen, Gloria M., Rotter, David, Tan, Xiang-Lin, Zhang, Lanjing   +9 more
core   +2 more sources

From Clinic to Computation: Multiscale Bioengineering Strategies for Durable Biological Aortic Valve Replacements

Advanced Functional Materials, EarlyView.
Bioprosthetic aortic valves have revolutionized the treatment of aortic stenosis, but their durability is limited by structural valve deterioration (SVD). This review focuses on the pericardial tissue at the heart of these valves, examining how its mechanical properties and calcification drive fatigue and failure.
Gabriele Greco, Pierfrancesco Gaziano, Serena Anglese, Simone Morganti, Carlo de Vincentiis, Ferdinando Auricchio, Michele Marino, Michele Conti   +7 more
wiley   +1 more source

Statins: antimicrobial resistance breakers or makers? [PDF]

PeerJ, 2017
Introduction The repurposing of non-antibiotic drugs as adjuvant antibiotics may help break antimicrobial resistance (AMR). Statins are commonly prescribed worldwide to lower cholesterol.
Humphrey H.T. Ko, Ricky R. Lareu, Brett R. Dix, Jeffery D. Hughes   +3 more
doaj   +2 more sources

Statin-associated muscle symptoms (SAMS) in primary prevention for cardiovascular disease in older adults:A protocol for a systematic review and meta-analysis of randomised controlled trials [PDF]

, 2017
IntroductionAlthough statins are commonly used for prevention of cardiovascular disease, there is limited evidence about statin-related adverse effects in older people. Statin-related adverse events (AEs), especially the statin-associated muscle symptoms
Albarqouni, Loai, Breslin, Monique, Curtis, Andrea J, Nelson, Mark, Zhou, Zhen   +4 more
core   +1 more source

Statins and sepsis [PDF]

British Journal of Anaesthesia, 2008
Severe sepsis and septic shock is common and frequently fatal. Over the last few years, the primary treatments demonstrated to improve outcome from several major clinical trials have finally emerged. However, translating these recent therapeutic advances to routine clinical practice has proven controversial, and new approaches of additional strategies ...
F, Gao, L, Linhartova, A McD, Johnston, D R, Thickett   +3 more
openaire   +2 more sources

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Exploitation of Aspergillus terreus for the Production of Natural Statins

Journal of Fungi, 2016
The fungus Aspergillus (A.) terreus has dominated the biological production of the “blockbuster” drugs known as statins. The statins are a class of drugs that inhibit HMG-CoA reductase and lead to lower cholesterol production.
Mishal Subhan, Rani Faryal, Ian Macreadie   +2 more
doaj   +1 more source