Results 51 to 60 of about 254,908 (357)

Statins interfere with the attachment of S. cerevisiae mtDNA to the inner mitochondrial membrane

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
The 3-hydroxy-3-methylglutaryl-CoA reductase, a key enzyme of the mevalonate pathway for the synthesis of cholesterol in mammals (ergosterol in fungi), is inhibited by statins, a class of cholesterol lowering drugs.
Angela Cirigliano, Antonia Amelina, Beatrice Biferali, Alberto Macone, Chiara Mozzetta, Michele Maria Bianchi, Mattia Mori, Bruno Botta, Elah Pick, Rodolfo Negri, Teresa Rinaldi   +10 more
doaj   +1 more source

Statins attenuate cholesterol-induced ROS via inhibiting NOX2/NOX4 and mitochondrial pathway in collecting ducts of the kidney

BMC Nephrology, 2022
Background Statins therapy has been primarily recommended for the prevention of cardiovascular risk in patients with chronic kidney diseases. Statins has also been proved some benefits in lipid-induced kidney diseases.
Ani Wang, Yu Lin, Baien Liang, Xiaoduo Zhao, Miaojuan Qiu, Hui Huang, Chunling Li, Weidong Wang, Yonglun Kong   +8 more
doaj   +1 more source

Statins Impair Antitumor Effects of Rituximab by Inducing Conformational Changes of CD20

PLoS Medicine, 2008
Background Rituximab is used in the treatment of CD20+ B cell lymphomas and other B cell lymphoproliferative disorders. Its clinical efficacy might be further improved by combinations with other drugs such as statins that inhibit cholesterol synthesis ...
M. Winiarska, J. Bil, E. Wilczek, Grzegorz M. Wilczynski, Małgorzata Lekka, P. Engelberts, Wendy J. M. Mackus, E. Górska, L. Bojarski, Tomasz Stokłosa, D. Nowis, Zuzanna Kurzaj, Marcin Makowski, Eliza Głodkowska, Tadeusz Issat, P. Mrówka, W. Lasek, Anna Dąbrowska-Iwanicka, Grzegorz W. Basak, Maria Wasik, Krzysztof Warzocha, M. Siński, Zbigniew A. Gaciong, M. Jakóbisiak, P. Parren, J. Gołąb   +25 more
semanticscholar   +1 more source

Modern Management of Asymptomatic Carotid Stenosis: A Meta‐Analysis of CREST‐2, SPACE‐2, and ECST‐2

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Recent randomized trials (CREST‐2, SPACE‐2, and ECST‐2) have compared carotid revascularization (carotid endarterectomy [CEA] or carotid artery stenting [CAS]) plus contemporary medical therapy (CMT) versus CMT alone in asymptomatic carotid stenosis.
Aasim Ali, Waqar Ahmed Cheema, Fiza Nisar, Muhammad Shamoon, Sameen Sarfaraz, Ahmad Butt, Muhammad Abdullah Ali, Armaghana Abdullah, Muhammad Asad Shabbir, Muhammad Talha, Hammad Azam, Aimen Anwaar Pannun, Usama Saleem, Anousha Tanveer, Mukesh Sharma   +14 more
wiley   +1 more source

The Adverse Effects of Statins Therapy

, 2021
statins are one of the most important drugs used in the prevention of cardiovascular events. There benefits however does come without side effects, which can be serious and its important to have a knowlege on their management.
Dekkar, Reihana
core  

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

There is a slight increase in incident diabetes risk with the use of statins, but benefits likely outweigh any adverse effects in those with moderate-to-high cardiovascular risk

, 2010
Statins are one of the most widely used drug classes, with approximately 50 million prescriptions dispensed in England alone in 2008. Their efficacy and safety in significantly reducing cardiovascular events in moderate-to-high-risk patients has been ...
Bhatia, Lokpal, L. Bhatia, Byrne, Christopher D., C. D. Byrne   +3 more
core   +1 more source

New insights into the therapeutic potentials of statins in cancer

Frontiers in Pharmacology, 2023
The widespread clinical use of statins has contributed to significant reductions of cardiovascular morbidity and mortality. Increasing preclinical and epidemiological evidences have revealed that dyslipidemia is an important risk factor for ...
Chengyu Liu, Hong Chen, Bicheng Hu, Jiajian Shi, Yuchen Chen, Kun Huang, Kun Huang   +6 more
doaj   +1 more source

Effects of Statins on Coronary Atherosclerotic Plaques: The PARADIGM Study.

JACC Cardiovascular Imaging, 2018
OBJECTIVES This study sought to describe the impact of statins on individual coronary atherosclerotic plaques. BACKGROUND Although statins reduce the risk of major adverse cardiovascular events, their long-term effects on coronary atherosclerosis ...
Sang-Eun Lee, H. Chang, J. Sung, Hyung-Bok Park, R. Heo, A. Rizvi, F. Lin, Amit Kumar, M. Hadamitzky, Yong Jin Kim, E. Conte, D. Andreini, G. Pontone, M. Budoff, I. Gottlieb, Byoung-Kwon Lee, E. Chun, Filippo Cademartiri, E. Maffei, H. Marques, J. Leipsic, Sanghoon Shin, J. Choi, K. Chinnaiyan, G. Raff, R. Virmani, H. Samady, P. Stone, D. Berman, J. Narula, L. Shaw, Jeroen J. Bax, J. Min   +32 more
semanticscholar   +1 more source

The Role of Structure and Biophysical Properties in the Pleiotropic Effects of Statins

International Journal of Molecular Sciences, 2020
Statins are a class of drugs used to lower low-density lipoprotein cholesterol and are amongst the most prescribed medications worldwide. Most statins work as a competitive inhibitor of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGR), but statin ...
Christopher Murphy, E. Deplazes, C. Cranfield, Alvaro Garcia   +3 more
semanticscholar   +1 more source