Results 71 to 80 of about 150,085 (313)
Advanced Science, EarlyView.Human neutrophils exist as two epigenetically imprinted subtypes defined by stable CD177 expression or absence — a ratio that persists across time, circadian rhythms, and inflammation. CD177− neutrophils display a distinct molecular landscape enriched in arginase 1 and lipid metabolism markers, accumulate in head‐and‐neck tumors, and associate with ...
Marcel Jung +39 more
wiley +1 more source
Hepatology, EarlyView., 2022 Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince +30 more
wiley +1 more source
Exploitation of Aspergillus terreus for the Production of Natural Statins
Journal of Fungi, 2016 The fungus Aspergillus (A.) terreus has dominated the biological production of the “blockbuster” drugs known as statins. The statins are a class of drugs that inhibit HMG-CoA reductase and lead to lower cholesterol production.
Mishal Subhan +2 more
doaj +1 more source
Gender difference in hipolipemic and anti-inflammatory effects of statins in diabetics with coronary artery disease [PDF]
Vojnosanitetski Pregled, 2009 Background/Aim. Statins produce hipolipemic and pleotropic effects on markers of inflammation with stabilization of atheromatous plaque. The aim of this paper was to examine gender difference in hipolipemic and antiinflammatory effects of statins in ...
Đinđić Boris +5 more
doaj +1 more source
, 2017 Purpose: Chronic obstructive pulmonary disease (COPD) is associated with increased lung cancer risk. We evaluated the association of statin use with lung cancer risk in COPD patients and identified which statins possess the highest chemopreventive ...
Liu, Ju-Chi;Yang, Tsung-Yeh;Hsu, Yi-Ping;Hao, Wen-Rui;Kao, Pai-Feng;Sung, Li-Chin;Chen, Chun-Chao;Wu, Szu-Yuan
core +1 more source
Validation of the Patient Health Questionnaire‐2 (PHQ‐2) in Detecting Depression Among Older Adults
AGING MEDICINE, EarlyView.PHQ‐2 effectively screens for geriatric depression with the optimal cut‐off of 3 points. ABSTRACT Objectives Depression screening tools like the Patient Health Questionnaire‐2 (PHQ‐2) are commonly used to detect depression. However, its performance in elderly populations has been less extensively studied compared to its broader adult use.
Francesco Salis +6 more
wiley +1 more source
Statins: antimicrobial resistance breakers or makers? [PDF]
PeerJ, 2017 Introduction The repurposing of non-antibiotic drugs as adjuvant antibiotics may help break antimicrobial resistance (AMR). Statins are commonly prescribed worldwide to lower cholesterol.
Humphrey H.T. Ko +3 more
doaj +2 more sources
Arthritis &Rheumatology, EarlyView.Objective Myositis‐specific autoantibodies guide the diagnosis and classification of idiopathic inflammatory myopathies, but current immunoassays vary in accuracy, particularly for autoantibodies associated with interstitial lung disease. To compare the performance of the luciferase immunoprecipitation systems (LIPS) assay with line blot and ...
Peter D. Burbelo +14 more
wiley +1 more source
Hepatology, EarlyView., 2022 NRPT 1X reduces ALT and ceramide 14:0 in 65% of subjects as compared to only 28% in the placebo group. Abstract Background and Aims The prevalence of NAFLD is increasing globally and on a path to becoming the most frequent cause of chronic liver disease. Strategies for the prevention and treatment of NAFLD are urgently needed.
Ryan W. Dellinger +7 more
wiley +1 more source
Indian Journal of Endocrinology and Metabolism, 2013 Statins are an established class of drugs with proven efficacy in cardiovascular risk reduction. The concern over statin safety was first raised with the revelation of myopathy and rhabdomyolysis with the use of now withdrawn cerivastatin.
Debasish Maji +3 more
doaj +1 more source