Results 41 to 50 of about 762,287 (195)

Patients on statins with elevated transaminases: Frequency of follow‐up creatine kinase testing and gastroenterology referral

British Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2917-2923, August 2026.
Abstract Purpose To quantify how often creatine kinase (CK) is measured after newly elevated aminotransferases in statin users, and whether absent CK data are associated with gastroenterology (GI) referrals. Methods Retrospective chart review of adult outpatients on statins with a first alanine/aspartate aminotransferase (ALT/AST) elevation during a 5 ...
Faris Shweikeh, Anas Kartoumah, Rajshri Joshi, Anjali Nadihaan, Mohammed Mouchli, Inderprit Singh   +5 more
wiley   +1 more source

Uncovering Coenzyme Q10‐Related Genetic Determinants of Statin‐Associated Muscle Symptoms: Evidence from the UK Biobank and the All of Us Research Program

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 475-483, August 2026.
Statin‐associated muscle symptoms (SAMS) are frequent adverse effects of statin therapy and have been hypothesized to result from impaired coenzyme Q10 (CoQ10) biosynthesis. Although genetic determinants of CoQ10 levels have been reported, genome‐wide association studies (GWASs) conducted specifically in statin users are lacking. Moreover, direct CoQ10
Da Hoon Lee, Yoon‐A Park, Yubin Song, Ji‐Min Han, Kyung Hee Choi, Myeong Gyu Kim, Hye Sun Gwak   +6 more
wiley   +1 more source

Lipid-lowering drugs (statins) and peripheral neuropathy

Electronic Physician, 2018
Background and aim: Peripheral neuropathy is a disorder with often unknown causes. Some drugs, including statins, are proposed to be among the causes of peripheral neuropathy.
Mohammadreza Emad, Hosein Arjmand, Hamid Reza Farpour, Bahareh Kardeh   +3 more
doaj   +1 more source

Crystal structure of a statin bound to a class II hydroxymethylglutaryl-CoA reductase

, 2003
Hydroxymethylglutaryl-CoA (HMG-CoA) reductase is the primary target in the current clinical treatment of hypercholesterolemias with specific inhibitors of the "statin" family.
Tabernero, Lydia; id_orcid, Rodwell, Victor W., Stauffacher, Cynthia V.   +2 more
core   +1 more source

Multi‐Target Anti‐Obesity Potential of Coula edulis Nut Extract in High‐Fat Diet‐Induced Obesity in Rats

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
This study evaluated the multi‐target anti‐obesity effects of Coula edulis nut extract (CEE) in high‐fat diet‐induced obese Wistar rats. Following 4 weeks of obesity induction, rats received oral CEE at 1 or 2 g/kg body weight, or orlistat for 5 weeks under continued high‐fat diet or normal diet conditions.
Chidimma Emmanuel Ibeneme, Item Justin Atangwho, Godwin Eneji Egbung, Diana Ochuole Odey, Chinedum Ekeleme Martins, Uket Nta Obeten, Wilson Arong Obio, Louisiane Patrick Nangah, Emmanuel O. Ibeneme, Daniel Ejim Uti   +9 more
wiley   +1 more source

Statin use is associated with a reduced incidence of colorectal cancer: a colonoscopy-controlled case–control study

BMC Gastroenterology, 2012
Background The aetiology of colorectal cancer (CRC) remains elusive in the majority of cases. There is experimental evidence to show that HMG-CoA reductase inhibitors (statins) may inhibit proliferation and induce cause apoptosis in CRC cells and ...
Broughton Thomas, Sington Jamie, Beales Ian LP   +2 more
doaj   +1 more source

A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside

Interdisciplinary Medicine, Volume 4, Issue 4, July 2026.
This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione, Ana Talamillo, Juan M. Falcón‐Pérez   +2 more
wiley   +1 more source

Integrated genomic and transcriptomic approaches reveal oxidative stress adaptation mechanisms in a mesotrione‐resistant Amaranthus tuberculatus biotype

Pest Management Science, Volume 82, Issue 7, Page 6387-6398, July 2026.
Integrated GWAS and transcriptomics in a Canadian waterhemp biotype reveal mesotrione resistance is polygenic and metabolically driven. Significant SNPs and 187 herbicide‐responsive genes point to enhanced redox homeostasis, glutathione‐linked detoxification, lipid/secondary metabolism, and oxidative stress responses. Resistance arises from coordinated,
Martin Laforest, Marianne Bessette, Geneviève Gagnon, Sandra Flores‐Mejia, Brahim Soufiane, Marie‐Claire Goulet, Dominique Michaud   +6 more
wiley   +1 more source

Statin use in patients with hormone receptor‐positive metastatic breast cancer treated with everolimus and exemestane

Cancer Medicine, 2023
Background We analyzed the effect of statins in patients with hormone receptor‐positive (HR+) metastatic breast cancer treated with everolimus + exemestane (EverX).
Kyoungmin Lee, Eunjin Noh, Seok Joo Moon, Yoonjung Yoonie Joo, Eun Joo Kang, Jae Hong Seo, In Hae Park   +6 more
doaj   +1 more source

Bibliometric Analysis of Cubebenes and Related Sesquiterpenes: Natural Occurrence, Biosynthesis, Pharmacological Activities, and In‐Silico‐Based Future Therapeutic Potential

eFood, Volume 7, Issue 3, June 2026.
Cubebene‐related sesquiterpenes, found across diverse biological sources, exhibit promising pharmacological activities, including anti‐inflammatory, neuroprotective, and anticancer effects. This review highlights their molecular diversity, ADME profiles, and predicted multitarget interactions, underscoring their therapeutic relevance and potential in ...
Khadija Boualam, Ahmet B. Ortaakarsu, Sohaib Khatib, Mohamed A. Farag, Mansour Sobeh   +4 more
wiley   +1 more source