Results 41 to 50 of about 13,154 (208)

Statin therapy in critical illness : an international survey of intensive care physicians' opinions, attitudes and practice [PDF]

, 2012
Background Pleotropic effects of statins on inflammation are hypothesised to attenuate the severity of and possibly prevent the occurrence of the host inflammatory response to pathogen and infection-related acute organ failure.
Di Gangi, Stefania, Kruger, Peter S., McAuley, Danny F., Perkins, Gavin D., Scales, Damon C., Shankar-Hari, Manu, Terblanche, Marius   +6 more
core   +1 more source

Hypotensive Effects of Statins: A Rapid Review [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Recently, hypertension has become a major global health concern that plays a substantial role in morbidity and mortality related to Cardiovascular Disease (CVD).
Smruti Besekar, Sangita Jogdand, Satyawan Singh Patel   +2 more
doaj   +1 more source

Effects of fluvastatin on insulin resistance and cardiac morphology in hypertensive patients [PDF]

, 2011
Among hypertensive patients, cardiovascular disease morbidity is common, even in those who are adequately treated. New pharmacological strategies to mitigate the burden of arterial hypertension are needed.
Batista, M. C., Buffani, A., Kohlmann, O., Ribeiro, A. B., Tavares, A., Teixeira, A. A., Zanella, M. T.   +6 more
core   +1 more source

Recent advances: rheumatology [PDF]

, 2000
No abstract ...
Madhok, R., Kerr, H., Capell, H.A.
core   +6 more sources

The effect of statins on psoriasis severity: a meta-analysis of randomized clinical trials

Archives of Medical Science, 2019
Introduction Statins may reduce the severity of psoriasis, but the available evidence is unclear. We conducted a meta-analysis of randomized controlled studies (RCTs) that investigated the effect of statins on psoriasis severity assessed with the ...
Mateusz Socha, Aldona Pietrzak, Ewelina Grywalska, Daniel Pietrzak, Dariusz Matosiuk, Paweł Kiciński, Jacek Rolinski   +6 more
doaj   +1 more source

Unintended effects of statins from observational studies in the general population: systematic review and meta-analysis. [PDF]

, 2014
BACKGROUND: Efficacy of statins has been extensively studied, with much less information reported on their unintended effects. Evidence from randomized controlled trials (RCTs) on unintended effects is often insufficient to support hypotheses generated ...
Adler, Alma, Casas, Juan P, Ebrahim, Shah, Macedo, Ana Filipa, Prieto-Merino, David, Taylor, Fiona Claire   +5 more
core   +2 more sources

Melatonin Promotes Improvement in Serum Lipid Levels and Liver Histopathology in Hyperlipidemic Rats

Lipids, EarlyView.
ABSTRACT Hyperlipidemia or dyslipidemia is the term used for the increase in lipid levels in blood plasma, usually occurring due to a high‐fat diet associated with a sedentary lifestyle. The increase in lipid levels can cause fatty infiltration in the liver known as hepatic steatosis, which can lead to inflammation, fibrosis, and necrosis consecutively.
Ana Cláudia Carvalho de Sousa, Jaiurte Gomes Martins da Silva, Érique Ricardo Alves, Laís Caroline da Silva Santos, Bruno José do Nascimento, Marcelle Mariana Sales de França, Vanessa Bischoff Medina, Ismaela Maria Ferreira de Melo, Álvaro Aguiar Coelho Teixeira, Valéria Wanderley Teixeira   +9 more
wiley   +1 more source

Isoprenoid biosynthesis in the erythrocytic stages of Plasmodium falciparum [PDF]

, 2011
The development of new drugs is one strategy for malaria control. Biochemical pathways localised in the apicoplast of the parasite, such as the synthesis of isoprenic precursors, are excellent targets because they are different or absent in the human ...
JORDÃO, Fabiana Morandi, KATZIN, Alejandro Miguel, KIMURA, Emília Akemi   +2 more
core   +3 more sources

Integrated genomic and transcriptomic approaches reveal oxidative stress adaptation mechanisms in a mesotrione‐resistant Amaranthus tuberculatus biotype

Pest Management Science, EarlyView.
Integrated GWAS and transcriptomics in a Canadian waterhemp biotype reveal mesotrione resistance is polygenic and metabolically driven. Significant SNPs and 187 herbicide‐responsive genes point to enhanced redox homeostasis, glutathione‐linked detoxification, lipid/secondary metabolism, and oxidative stress responses. Resistance arises from coordinated,
Martin Laforest, Marianne Bessette, Geneviève Gagnon, Sandra Flores‐Mejia, Brahim Soufiane, Marie‐Claire Goulet, Dominique Michaud   +6 more
wiley   +1 more source

Regulatory effects of statins on CCL2/CCR2 axis in cardiovascular diseases: new insight into pleiotropic effects of statins

Journal of Inflammation
Background HMG-CoA reductase inhibitors are well-known medications in the treatment of cardiovascular disorders due to their pleiotropic and lipid-lowering properties. Herein, we reviewed the effects of statins on the CCL2/CCR2 axis.
Hanieh Gholamalizadeh, Behzad Ensan, Sercan Karav, Tannaz Jamialahmadi, Amirhossein Sahebkar   +4 more
doaj   +1 more source