Results 31 to 40 of about 24,284 (163)

Effects of Statin Use for Primary Prevention among Adults Aged 75 Years and Older in the National Health Insurance Service Senior Cohort (2002–2015) [PDF]

Annals of Geriatric Medicine and Research, 2020
Background This study aimed to identify adverse events and mortality in adults aged 75 years and older who were initially prescribed statins for primary prevention.
Sunyoung Kim, Hangseok Choi, Chang Won Won   +2 more
doaj   +1 more source

Crystal Structure of a Statin Bound to a Class II Hydroxymethylglutaryl-CoA Reductase*

Journal of Biological Chemistry, 2003
Hydroxymethylglutaryl-CoA (HMG-CoA) reductase is the primary target in the current clinical treatment of hypercholesterolemias with specific inhibitors of the “statin” family.
L. Tabernero, V. Rodwell, C. Stauffacher
semanticscholar   +1 more source

Risk of new-onset diabetes associated with statin use

SAGE Open Medicine, 2015
Objective: To identify and assess studies investigating the association between statins and new-onset diabetes and determine the clinical significance of this risk.
Robert D Beckett, Sarah M Schepers, Sarah K Gordon   +2 more
doaj   +1 more source

Underuse of statins for secondary prevention of atherosclerotic cardiovascular disease events among ambulatory surgical patients

Preventive Medicine Reports, 2020
Although statins are highly effective for reducing cardiovascular disease events, prior studies demonstrate their significant underuse in the US population, including among those with known atherosclerotic disease.
Robert B. Schonberger, Vivek Vallurupalli, Hollie Matlin, Daina Blitz, Adambeke Nwozuzu, Brian Barron, Yuemei Zhang, Feng Dai, Daniel Jacoby, Khurram Nasir, Amit Bardia   +10 more
doaj   +1 more source

Hypotensive Effects of Statins: A Rapid Review [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Recently, hypertension has become a major global health concern that plays a substantial role in morbidity and mortality related to Cardiovascular Disease (CVD).
Smruti Besekar, Sangita Jogdand, Satyawan Singh Patel   +2 more
doaj   +1 more source

The effect of statins on psoriasis severity: a meta-analysis of randomized clinical trials

Archives of Medical Science, 2019
Introduction Statins may reduce the severity of psoriasis, but the available evidence is unclear. We conducted a meta-analysis of randomized controlled studies (RCTs) that investigated the effect of statins on psoriasis severity assessed with the ...
Mateusz Socha, Aldona Pietrzak, Ewelina Grywalska, Daniel Pietrzak, Dariusz Matosiuk, Paweł Kiciński, Jacek Rolinski   +6 more
doaj   +1 more source

Hydroxymethylglutaryl‐CoA reductase activity is essential for mitochondrial β‐oxidation of fatty acids to prevent lethal accumulation of long‐chain acylcarnitines in the mouse liver

British Journal of Pharmacology
Statins are competitive inhibitors of 3‐hydroxy‐3‐methylglutaryl coenzyme A (HMG‐CoA) reductase (HMGCR), and exert adverse effects on mitochondrial function, although the mechanisms underlying these effects remain unclear.
E. Liepinsh, L. Zvejniece, Laura E Clemensson, Melita Ozola, Edijs Vavers, H. Cirule, S. Korzh, S. Skuja, V. Groma, M. Brīvība, S. Grinberga, Wen Liu, Paweł Olszewski, M. Gentreau, R. Fredriksson, M. Dambrova, H. Schiöth   +16 more
semanticscholar   +1 more source

Regulatory effects of statins on CCL2/CCR2 axis in cardiovascular diseases: new insight into pleiotropic effects of statins

Journal of Inflammation
Background HMG-CoA reductase inhibitors are well-known medications in the treatment of cardiovascular disorders due to their pleiotropic and lipid-lowering properties. Herein, we reviewed the effects of statins on the CCL2/CCR2 axis.
Hanieh Gholamalizadeh, Behzad Ensan, Sercan Karav, Tannaz Jamialahmadi, Amirhossein Sahebkar   +4 more
doaj   +1 more source

Statins: a tale of two pathways—cardiovascular savior, renal ineffectual [PDF]

Precision and Future Medicine
Statins are effective in improving outcomes in the general population. However, in patients with chronic kidney disease (CKD), clinical outcomes and therapeutic approaches require careful interpretation from multiple perspectives.
Jihyun Yang
doaj   +1 more source

Case report: Rhabdomyolysis and kidney injury in a statin-treated hypothyroid patient–kill two birds with one stone

Frontiers in Medicine, 2022
Statin treatment for hypercholesterolemia may cause reversible rhabdomyolysis and acute kidney injury in susceptible patients. However, persistent rhabdomyolysis and acute kidney injury following discontinuation of statins require careful evaluation of ...
Wen-Fang Chiang, Wen-Fang Chiang, Jenq-Shyong Chan, Jenq-Shyong Chan, Po-Jen Hsiao, Po-Jen Hsiao, Shih-Hua Lin   +6 more
doaj   +1 more source