Results 31 to 40 of about 762,287 (195)

Hypotensive Effects of Statins: A Rapid Review [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Recently, hypertension has become a major global health concern that plays a substantial role in morbidity and mortality related to Cardiovascular Disease (CVD).
Smruti Besekar, Sangita Jogdand, Satyawan Singh Patel   +2 more
doaj   +1 more source

Underuse of statins for secondary prevention of atherosclerotic cardiovascular disease events among ambulatory surgical patients

Preventive Medicine Reports, 2020
Although statins are highly effective for reducing cardiovascular disease events, prior studies demonstrate their significant underuse in the US population, including among those with known atherosclerotic disease.
Robert B. Schonberger, Vivek Vallurupalli, Hollie Matlin, Daina Blitz, Adambeke Nwozuzu, Brian Barron, Yuemei Zhang, Feng Dai, Daniel Jacoby, Khurram Nasir, Amit Bardia   +10 more
doaj   +1 more source

Melatonin Promotes Improvement in Serum Lipid Levels and Liver Histopathology in Hyperlipidemic Rats

Lipids, Volume 61, Issue 5, Page 583-593, September 2026.
ABSTRACT Hyperlipidemia or dyslipidemia is the term used for the increase in lipid levels in blood plasma, usually occurring due to a high‐fat diet associated with a sedentary lifestyle. The increase in lipid levels can cause fatty infiltration in the liver known as hepatic steatosis, which can lead to inflammation, fibrosis, and necrosis consecutively.
Ana Cláudia Carvalho de Sousa, Jaiurte Gomes Martins da Silva, Érique Ricardo Alves, Laís Caroline da Silva Santos, Bruno José do Nascimento, Marcelle Mariana Sales de França, Vanessa Bischoff Medina, Ismaela Maria Ferreira de Melo, Álvaro Aguiar Coelho Teixeira, Valéria Wanderley Teixeira   +9 more
wiley   +1 more source

The effect of statins on psoriasis severity: a meta-analysis of randomized clinical trials

Archives of Medical Science, 2019
Introduction Statins may reduce the severity of psoriasis, but the available evidence is unclear. We conducted a meta-analysis of randomized controlled studies (RCTs) that investigated the effect of statins on psoriasis severity assessed with the ...
Mateusz Socha, Aldona Pietrzak, Ewelina Grywalska, Daniel Pietrzak, Dariusz Matosiuk, Paweł Kiciński, Jacek Rolinski   +6 more
doaj   +1 more source

Effects of Statin Use for Primary Prevention among Adults Aged 75 Years and Older in the National Health Insurance Service Senior Cohort (2002–2015) [PDF]

Annals of Geriatric Medicine and Research, 2020
Background This study aimed to identify adverse events and mortality in adults aged 75 years and older who were initially prescribed statins for primary prevention.
Sunyoung Kim, Hangseok Choi, Chang Won Won   +2 more
doaj   +1 more source

A cofactor‐promiscuous HMGR from the Lyme disease pathogen illuminates diversity in bacterial isoprenoid biosynthesis

Protein Science, Volume 35, Issue 9, September 2026.
Abstract The Lyme disease pathogen Borrelia burgdorferi contains a highly reduced genome lacking many primary metabolic pathways. However, B. burgdorferi retains the mevalonate pathway that synthesizes isopentenyl pyrophosphate (IPP), the precursor to the peptidoglycan carrier lipid.
Isaac A. Paddy, Joshua McCausland, Madelyn Frazier, Poulami Chatterjee, Mekedlawit Setegne, Oliv Eidam, Christine Jacobs‐Wagner, Laura M. K. Dassama   +7 more
wiley   +1 more source

Regulatory effects of statins on CCL2/CCR2 axis in cardiovascular diseases: new insight into pleiotropic effects of statins

Journal of Inflammation
Background HMG-CoA reductase inhibitors are well-known medications in the treatment of cardiovascular disorders due to their pleiotropic and lipid-lowering properties. Herein, we reviewed the effects of statins on the CCL2/CCR2 axis.
Hanieh Gholamalizadeh, Behzad Ensan, Sercan Karav, Tannaz Jamialahmadi, Amirhossein Sahebkar   +4 more
doaj   +1 more source

Ubiquitin and ubiquitin‐like modifications in the endoplasmic reticulum stress response

The FEBS Journal, Volume 293, Issue 18, Page 5481-5513, September 2026.
Endoplasmic reticulum (ER) stress activates various proteostasis control processes, including the unfolded protein response, ribosome‐associated quality control, and ER‐associated degradation. Ubiquitin and ubiquitin‐like modifications dynamically regulate these processes to determine cell fate, promoting adaptation or inducing cell death.
Tony Avril, Matthieu Le Gallo, Elodie Lafont   +2 more
wiley   +1 more source

Meta-Analysis: Hydroxymethylglutaryl Coenzyme A Reductase Inhibitors in Thoracic Transplant Patients

, 2006
Class of 2006 AbstractObjectives: To evaluate the efficacy of hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, or statins, in reducing all-cause mortality and death due to rejection when administered to thoracic organ transplant patients.
Moon, Rebecca
core   +5 more sources

Statins: a tale of two pathways—cardiovascular savior, renal ineffectual [PDF]

Precision and Future Medicine
Statins are effective in improving outcomes in the general population. However, in patients with chronic kidney disease (CKD), clinical outcomes and therapeutic approaches require careful interpretation from multiple perspectives.
Jihyun Yang
doaj   +1 more source