Involvement of Rho-associated protein kinase (ROCK) and bone morphogenetic protein-binding endothelial cell precursor-derived regulator (BMPER) in high glucose-increased alkaline phosphatase expression and activity in human coronary artery smooth muscle cells [PDF]
, 2015 BACKGROUND: Vascular calcification is an independent risk factor for cardiovascular disease. Diabetes mellitus increases the incidence of vascular calcification; however, detailed molecular mechanisms of vascular calcification in diabetes mellitus remain
Ken-ichi Hirata +3 more
core +2 more sources
Effectiveness of statin treatment for recurrent stroke according to stroke subtypes [PDF]
Journal of Medicine and Life ScienceUnderstanding the effectiveness of statin treatment is essential for developing tailored stroke prevention strategies. We aimed to evaluate the efficacy of statin treatment in preventing recurrent stroke among patients with various ischemic stroke ...
Min-Surk Kye +15 more
doaj +1 more source
Evaluating early administration of the hydroxymethylglutaryl-CoA reductase inhibitor simvastatin in the prevention and treatment of delirium in critically ill ventilated patients (MoDUS trial): study protocol for a randomized controlled trial [PDF]
Trials, 2015 The incidence of delirium in ventilated patients is estimated at up to 82%, and it is associated with longer intensive care and hospital stays, and long-term cognitive impairment and mortality. The pathophysiology of delirium has been linked with inflammation and neuronal apoptosis.
Casarin, Annalisa +9 more
openaire +4 more sources
Pharmacologic approaches against advanced glycation end products (ages) in diabetic cardiovascular disease [PDF]
, 2015 Advanced Glycation End-Products (AGEs) are signaling proteins associated to several vascular and neurological complications in diabetic and non-diabetic patients.
Avtaar Singh, Sanjeet Singh +6 more
core +2 more sources
Chemoprevention of Gastric Cancer: Statins
The Korean Journal of Helicobacter and Upper Gastrointestinal Research, 2017 Gastric cancer is one of the leading causes of cancer-related deaths worldwide. Because the gastric cancer-related mortality rate is expected to increase, chemo-preventive strategies for gastric cancer are required.
Sang Hyeon Choi, Gwang Ho Baik
doaj +1 more source
Effects of Statin Use for Primary Prevention among Adults Aged 75 Years and Older in the National Health Insurance Service Senior Cohort (2002–2015) [PDF]
Annals of Geriatric Medicine and Research, 2020 Background This study aimed to identify adverse events and mortality in adults aged 75 years and older who were initially prescribed statins for primary prevention.
Sunyoung Kim +2 more
doaj +1 more source
A systematic review and meta-analysis of the effect of statins on osteoporotic fractures [PDF]
Journal of NephropharmacologyIntroduction: Statins can increase bone density and improve osteoporosis. As fractures are the worst outcome of osteoporosis, our study aimed to investigate the relationship between statins and osteoporotic fractures using a systematic review and meta ...
Shahin Asgari-Savadjani +2 more
doaj +1 more source
THE CONCISE GUIDE TO PHARMACOLOGY 2017/18:Enzymes [PDF]
, 2017 The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and ...
, +11 more
core +15 more sources
Risk of new-onset diabetes associated with statin use
SAGE Open Medicine, 2015 Objective: To identify and assess studies investigating the association between statins and new-onset diabetes and determine the clinical significance of this risk.
Robert D Beckett +2 more
doaj +1 more source
Preventive Medicine Reports, 2020 Although statins are highly effective for reducing cardiovascular disease events, prior studies demonstrate their significant underuse in the US population, including among those with known atherosclerotic disease.
Robert B. Schonberger +10 more
doaj +1 more source