Results 51 to 60 of about 115,838,581 (186)

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Disease-associated mutations in Niemann-Pick type C1 alter ER calcium signaling and neuronal plasticity [PDF]

, 2019
Niemann-Pick type C1 (NPC1) protein is essential for the transport of externally derived cholesterol from lysosomes to other organelles. Deficiency of NPC1 underlies the progressive NPC1 neurodegenerative disorder.
Vivas, Oscar, Dixon, Rose E, Scott A. Tiscione, Santana, Luis F, Eamonn J. Dickson, Oscar Vivas, Donald M. Bers, Luis F. Santana, Kenneth S. Ginsburg, Rose E. Dixon, Tiscione, Scott A, Dickson, Eamonn J, Daniel S. Ory, Ory, Daniel S, Bers, Donald M, Ginsburg, Kenneth S   +15 more
core   +1 more source

Identifizierung und Charakterisierung von pharmakologischen Chaperonen zur Behandlung von Morbus Niemann-Pick Typ C1 unter Verwendung von neuralen und Hepatozyten-ähnlichen Zellen abgeleitet aus patientenspezifischen induzierten pluripotenten Stammzellen [PDF]

, 2022
Das Ziel der vorliegenden Arbeit war die Identifizierung und Charakterisierung von pharmakologischen Chaperonen zur Behandlung von Morbus Niemann-Pick Typ C1 (NP-C1) unter Verwendung von neuralen und Hepatozyten-ähnlichen Zellen abgeleitet aus ...
Völkner, Christin (gnd: 1275524036)
core   +1 more source

Regulation of intestinal NPC1L1 expression by dietary fish oil and docosahexaenoic acid

Journal of Lipid Research, 2007
To address the effect of the n-3 fatty acid, docosahexaenoic acid (22:6), on proteins that play a role in cholesterol absorption, CaCo-2 cells were incubated with taurocholate micelles alone or micelles containing 22:6 or oleic acid (18:1). Compared with
Satya N. Mathur, Kim R. Watt, F. Jeffrey Field   +2 more
doaj   +1 more source

Altered gene expression in the liver and small intestine of horses with equine neuroaxonal dystrophy

Equine Veterinary Journal, EarlyView.
Abstract Background Equine neuroaxonal dystrophy/degenerative myeloencephalopathy (eNAD/EDM) is the second most common diagnosis of spinal ataxia in horses in the United States. The disease develops due to a combination of vitamin E deficiency and an unknown genetic risk factor(s), and there currently is no effective treatment.
Stephanie Ryan, Blythe Durbin‐Johnson, Kevin Woolard, Andrew D. Miller, Carrie J. Finno   +4 more
wiley   +1 more source

Funktionelle Charakterisierung von zerebellären Purkinjezellen eines Mausmodells des Morbus Niemann-Pick Typ C1 [PDF]

, 2019
Morbus Niemann Pick Typ C1 (NPC1) ist durch den Verlust von zerebellären Purkinjezellen gekennzeichnet, der in einer zerebellären Ataxie zum Ausdruck kommt. Hierbei sind die zugrunde liegenden pathophysiologischen Vorgänge nur ungenügend verstanden. Ziel
Rabenstein, Michael Jürgen (gnd: 1203734778)
core   +1 more source

Cholesterol auxotrophy and intolerance to ezetimibe in mice with SREBP-2 deficiency in the intestine

Journal of Lipid Research, 2017
SREBP-2 activates transcription of all genes needed for cholesterol biosynthesis. To study SREBP-2 function in the intestine, we generated a mouse model (Vil-BP2−/−) in which Cre recombinase ablates SREBP-2 in intestinal epithelia. Intestines of Vil-BP2−/
Shunxing Rong, Jeffrey G. McDonald, Luke J. Engelking   +2 more
doaj   +1 more source

Therapeutic potential of okra (Abelmoschus esculentus) in dysglycaemia and metabolic dysfunction: A systematic review and meta‐analysis across the diabetes spectrum

Experimental Physiology, EarlyView.
Abstract The aim of this systematic review and meta‐analysis was to evaluate comprehensively the therapeutic potential of Abelmoschus esculentus (okra) supplementation across the diabetes spectrum of key metabolic risk factors. A search was conducted in PubMed, Scopus, Web of Science, EMBASE and the Cochrane Library, up to 23 July 2025, to identify ...
Ali Jafari, Helia Mardani, Mohammad Amin Karimi, MohammadHossein Sahami Gilan, Helia Hemmat, Fatemeh Shoja, Nooshin Enayati Soofi, Ghazaleh Eslamian   +7 more
wiley   +1 more source

NIEMANN-PICK C1-LIKE 1 PROTEIN (NPC1L1) FROM GENETICS TO PHARMACOLOGY FOR THE CONTROL OF HYPERCHOLESTEROLAEMIA

, 2022
reservedIn questa tesi ho deciso di seguire il percorso che ha portato, a partire dalla scoperta di una grave e rara malattia, quale la malattia di Niemann-Pick di tipo C, allo studio di una proteina specifica che regola l’assorbimento intestinale del ...
POMARI, CARLOTTA
core  

The Niemann-Pick C1 gene interacts with a high-fat diet to promote weight gain through differential regulation of central energy metabolism pathways.

, 2017
A genome-wide association study (GWAS) reported that common variation in the human Niemann-Pick C1 gene
L. John Horwood, Garver, William S, Robert A. Orlando, Orlando, Robert A, Garcia-Smith, Randi, Horwood, L John, Kristina A. Trujillo, Trujillo, Kristina A, David Meyre, William S. Garver, LeBoeuf, Renee C, Castillo, Joseph J, David Jelinek, Nicholas P. Gannon, Wei, Hao, Hao Wei, Randi Garcia-Smith, Meyre, David, F. John Meaney, Randall A. Heidenreich, Renee C. LeBoeuf, Vaughan, Roger A, Joseph J. Castillo, Meaney, F John, Heidenreich, Randall A, Jelinek, David, Gannon, Nicholas P, Roger A. Vaughan   +27 more
core   +2 more sources