Results 71 to 80 of about 115,838,581 (186)

Malaria mosquito antimicrobial defence requires immunity and detoxification gene regulation by Lola

Insect Molecular Biology, Volume 35, Issue 5, Page 576-593, October 2026.
Malaria mosquito antimicrobial defence requires upregulation of lola. Attenuation of lola in the midgut of Anopheles albimanus mosquitoes inhibits the upregulation of immunity genes induced by challenge. Putative target genes of the Lola transcription factor were revealed by lola attenuation, including Cecropin‐C, Draper, PPAF2, Clip‐domain serine ...
Heidi Espadas‐Álvarez, Verónica Valverde‐Garduño   +1 more
wiley   +1 more source

Niemann–Pick disease type C1 presenting with psychosis in an adolescent male [PDF]

, 2009
Niemann–Pick disease, a neurovisceral lysosomal lipid storage disorder, is a rare disorder that is unknown to many clinicians. The disease, that often has its onset during childhood or adolescence, shows a polymorphic clinical picture, including ...
Bachmann, Christian, Jackowski-Dohrmann, Sabine, Sandu, Sabine, Haberhausen, Michael, Ladner, Axel   +4 more
core   +1 more source

CD81-Receptor Associations — Impact for Hepatitis C Virus Entry and Antiviral Therapies

Viruses, 2014
Tetraspanins are integral transmembrane proteins organized in microdomains displaying specific and direct interactions with other tetraspanins and molecular partners.
Laetitia Zona, Rajiv G. Tawar, Mirjam B. Zeisel, Fei Xiao, Catherine Schuster, Joachim Lupberger, Thomas F. Baumert   +6 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, Volume 600, Issue 17, Page 2526-2546, September 2026.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Role of NPC1L1 (Niemann‐Pick C1‐Like 1) in preventing hepatic steatosis

The FASEB Journal, 2013
NPC1L1 (Niemann‐Pick C1‐like 1) protein is known as a multipass membrane protein for cholesterol transport, found in liver and intestine, which involved in intracellular cholesterol synthesis and absorption. NPC1L1 inhibitor, ezetimibe has been used as a cholesterol‐lowering drug for diabetes and cardiovascular disease.
Eugene Chang, Lisa Kim, Jung‐Mook Choi, Cheol‐Young Park   +3 more
openaire   +1 more source

Metabolic Memory in Cardiovascular Disease: Encoding, Propagation, and Therapeutic Targeting

Advanced Science, Volume 13, Issue 54, 28 September 2026.
Cardiovascular risk often persists after metabolic abnormalities are corrected. This conceptual Review frames such persistence as metabolic memory, encoded through a narrowing therapeutic window from reversible marks to irreversible damage, with continuous input from peripheral organs.
Cheng Cheng, Minghui Tang, Zhaobo Zhang, Ruoyi Qu, Jianfei Pei, Tian Liu, Siyao Qu, Shilong You, Shenshen Cui, Wenke Wang, Rui Zhao, Yingxian Sun, Naijin Zhang   +12 more
wiley   +1 more source

Pravastatin Modulate Niemann-Pick C1-Like 1 and ATP-Binding Cassette G5 and G8 to Influence Intestinal Cholesterol Absorption

Journal of Pharmacy & Pharmaceutical Sciences, 2015
Purpose. Niemann-Pick C1-like 1 (NPC1L1), ATP-binding cassette (ABC)G5, and ABCG8 mediate intestinal cholesterol absorption. It is unclear whether pravastatin (PR) or ezetimibe (EZ) affect expression of these transporters.
Atsushi Kawase, Seiji Hata, Mai Takagi, Masahiro Iwaki   +3 more
doaj   +1 more source

A multiplex interactome of Ebola virus proteins reveals TM9SF2 as a cell‐surface attachment factor that promotes viral entry

iMetaOmics, Volume 3, Issue 3, September 2026.
This study generates a comprehensive Ebola virus (EBOV)‐human protein–protein interactome, comprising 1728 core high‐confidence interactions. Further interactome analysis revealed the potential association of EBOV glycoprotein (GP) with the host factor TM9SF2. Subsequent mechanistic investigations confirmed that TM9SF2 functions as an attachment factor
Limin Shang, Shouwen Du, Yuchen Liu, Letian Li, Xi Wu, Yanzhi Yuan, Chaozhi Jin, Qingkun Mi, Yuhang Wang, Xiaoshuang Shi, Jiamin Wang, Guoqing Zhang, Yidan Ma, Weijin Huang, Jigang Wang, Jian Wang, Chang Li   +16 more
wiley   +1 more source

Niemann-Pick C1-Like 1 Is Required for an LXR Agonist to Raise Plasma HDL Cholesterol in Mice [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2008
Objectives—Activation of liver x receptor (LXR) raises plasma HDL-cholesterol (HDL-C) in mice. Interestingly, the LXR agonist GW3965 fails to raise plasma HDL-C in mice lacking intestinal ABCA1, indicating that intestinal ABCA1 plays a predominant role in GW3965-mediated HDL production.
Weiqing, Tang, Yinyan, Ma, Lin, Jia, Yiannis A, Ioannou, Joanna P, Davies, Liqing, Yu   +5 more
openaire   +2 more sources

Aproximació terapèutica per a la malaltia de Gaucher basada en xaperones [PDF]

, 2011
[cat] En aquesta tesi s’ha realitzat una aproximació terapèutica per a la malaltia de Gaucher, basada en xaperones farmacològiques. La malaltia de Gaucher és una malaltia d’acúmul lisosòmic d'herència autosòmica recessiva, causada per mutacions en el ...
Sànchez Ollé, Gessamí
core   +4 more sources