Results 91 to 100 of about 115,838,581 (186)

Nucleotide sequence of primers used in real-time quantitative PCR (arp: acidic ribosomal phosphoprotein P0, pep: pepsinogen, lip: triglyceride lipase, amy: α-amylase, slc7a8: large neutral amino acids transporter small subunit 2, sglt1: sodium/glucose co-transporter member 1 and npc1l1: Niemann-Pick C1-Like 1).

, 2015
Nucleotide sequence of primers used in real-time quantitative PCR (arp: acidic ribosomal phosphoprotein P0, pep: pepsinogen, lip: triglyceride lipase, amy: α-amylase, slc7a8: large neutral amino acids transporter small subunit 2, sglt1: sodium/glucose co-
Shu-Hwa Chen (10210), Chung-Yen Lin (10205), Hsiang-Yi Hsu (800248), Katsumi Tsukamoto (181108), Yu-San Han (182132), Yuh-Ru Cha (800249)   +5 more
core   +1 more source

Plasmodium Niemann-Pick Type C1-Related protein is a druggable target required for parasite membrane homeostasis [PDF]

, 2019
Plasmodium parasites possess a protein with homology to Niemann-Pick Type C1 proteins (Niemann-Pick Type C1-Related protein, NCR1). We isolated parasites with resistance- conferring mutations in Plasmodium falciparum NCR1 (PfNCR1) during selections with ...
Winzeler, Elizabeth, Goldberg, Daniel E, Vaidya, Akhil B, Das, Sudipta, Niles, Jacquin C, Llinas, Manuel, Istvan, Eva S, Owen, Edward, Ganesan, Suresh M, Beck, Josh R, Bhatnagar, Suyash, Maddur Ganesan, Suresh, Niles, Jacquin   +12 more
core   +1 more source

Investigation of NPC1L1 and NPC2 Protein Levels in Patients with Cholelithiasis: Implications for Cholesterol Transport and Gallbladder Inflammation

Cumhuriyet Science Journal
Cholelithiasis is a common hepatobiliary disorder associated with impaired cholesterol homeostasis and chronic inflammation. Niemann–Pick C1-Like 1 (NPC1L1) and Niemann–Pick C2 (NPC2) are proteins involved in cholesterol transport; however, their roles ...
Hüsnü Çağrı Genç, Hakkı Coşkun, Cemile Zontul, Ayça Taş, Ömer Topcu, Yavuz Siliğ   +5 more
doaj   +1 more source

Combination of Ezetimibe and Garlic Reduces Serum Lipids and Intestinal Niemann-Pick C1-like 1 Expression More Effectively in Hypercholesterolemic Mice

Avicenna Journal of Medical Biochemistry, 2015
Background Combination therapy plays an important role in the management of cardiovascular disease (CVD). Objectives The aim of this experiment was to study the influence of garlic combined with ezetimibe ...
Mohammadi, Vafaei, Nabi Moradi, Ahmadi, Pourjafar, Abbasi Oshaghi   +5 more
doaj   +1 more source

Origins of intestinal ABCA1-mediated HDL-cholesterol*

Journal of Lipid Research, 2008
The origins of cholesterol utilized by intestinal ABCA1 were investigated in the human intestinal cell line Caco-2. Influx of apical membrane cholesterol increases ABCA1 mRNA and mass, resulting in enhanced efflux of HDL-cholesterol.
F. Jeffrey Field, Kim Watt, Satya N. Mathur   +2 more
doaj   +1 more source

Ezetimibe Induces Paraptosis through Niemann-Pick C1-like 1 Inhibition of Mammalian-Target-of-Rapamycin Signaling in Hepatocellular Carcinoma Cells. [PDF]

Genes (Basel), 2023
Yin Y, Wu C, Zhou Y, Zhang M, Mai S, Chen M, Wang HY.   +6 more
europepmc   +1 more source

Reduced cholesterol absorption upon PPARδ activation coincides with decreased intestinal expression of NPC1L1

Journal of Lipid Research, 2005
Peroxisome proliferator-activated receptors (PPARs) control the transcription of genes involved in lipid metabolism. Activation of PPARδ may have antiatherogenic effects through the increase of plasma HDL, theoretically promoting reverse cholesterol ...
Jelske N. van der Veen, Janine K. Kruit, Rick Havinga, Julius F.W. Baller, Giovanna Chimini, Sophie Lestavel, Bart Staels, Pieter H.E. Groot, Albert K. Groen, Folkert Kuipers   +9 more
doaj   +1 more source

Cerebrospinal Fluid total Tau in individuals with Niemann-Pick Disease type C1

Cerebrospinal Fluid Total Tau levels in individuals with Niemann-Pick Disease type C1.
Porter, Forbes
core   +1 more source

MOESM1 of Expanded access with intravenous hydroxypropyl-β-cyclodextrin to treat children and young adults with Niemann-Pick disease type C1: a case report analysis

, 2019
Additional file 1. Supplemental Data: Case Summaries on Compassionate Use HPβCD to accompany the manuscript “Expanded access with intravenous hydroxypropyl-β-cyclodextrin to treat children and young adults with Niemann-Pick disease Type C1: A case report
Cyrus Bascon (7527368), Raymond Wang (7527374), Sharon Hrynkow (7527380), Benny Liu (7527365), Claire Gao (7527371), Caroline Hastings (7527359), Camilo Vieira (7527362), Alicia Casey (7527377)   +7 more
core   +1 more source

Altered transition metal homeostasis in Niemann-Pick disease, type C1 [PDF]

, 2014
The loss of NPC1 protein function is the predominant cause of Niemann-Pick type C1 disease (NP-C1), a systemic and neurodegenerative disorder characterized by late-endosomal/lysosomal accumulation of cholesterol and other lipids.
Killilea, DW, Firnkes, S, Yanjanin, N, Hastings, C, Ganio, G, Bush, AI, Walterfang, M, Hung, YH, Ory, DS, Porter, FD, Faux, NG, Volitakis, I   +11 more
core   +1 more source