Results 111 to 120 of about 115,838,581 (186)

Triglyceride-lowering effect of rice protein due to the regulation of fatty acid uptake and transport of triglyceride in rats fed normal/oil-enriched diets

Food Chemistry: Molecular Sciences
Dysregulation of fatty acid uptake and triglyceride transport can induce excess triglyceride accumulation. We propose that rice protein might suppress fatty acid uptake and/or triglyceride transport.
Bingxiao Liu, Zhengxuan Wang, Mingcai Liang, Lin Yang   +3 more
doaj   +1 more source

Dual functions of NPC1L1 for cholesterol transport: Cholesterol capture and regulation of inner-leaflet cholesterol accessibility

iScience
Summary: Niemann-Pick C1-like 1 (NPC1L1) is essential for intestinal cholesterol absorption, but the detailed mechanisms underlying its non-vesicular cholesterol transport remain unclear.
Yoshihide Yamanashi, Maiko Kitani, Megumi Kumamaru, Tomoki Fukaya, Rina Sugita, Tappei Takada   +5 more
doaj   +1 more source

Investigation of loss of Cathepsin B in Niemann Pick disease, type C1

Experiments investigating the effect of the loss of Cathepsin B (Ctsb-/-) in Niemann Pick type C1 deficient mice. Summary: Double mutant mice with the loss of Cathepsin B (Ctsb) and Niemann Pick type C1 (Npc1) were generated and analyzed with respect ...
Cawley, Niamh
core   +1 more source

The regulation of Niemann-Pick C1-Like 1 (NPC1L1) gene expression in opposite direction by Bacteroides spp. and related outer membrane vesicles in Caco-2 cell line. [PDF]

J Diabetes Metab Disord, 2020
Badi SA, Motahhary A, Bahramali G, Masoumi M, Khalili SFS, Ebrahimzadeh N, Nouri P, Rahimi A, Masotti A, Moshiri A, Siadat SD.   +10 more
europepmc   +1 more source

Niemann-Pick C1-Like Protein 1 [PDF]

, 2020
openaire   +1 more source

Research Progress of Niemann-Pick-C1-Like 1, a Key Target Related to Cholesterol Absorption

Pharmacy Information, 2013
NPC1L1是近年发现对胆固醇的吸收有调控作用的新靶点。在小肠内NPC1L1蛋白与胆固醇吸收直接相关。NPC1L1蛋白与相关胆固醇转运蛋白Flotillin-1和Flotillin-2相互作用，将胆固醇和其他甾醇转运通过肠上皮细胞刷状缘、运送到肠上皮细胞内。降胆固醇药物Ezetimibe正是阻断了NPC1L1和Flotillin-1和Flotillin-2的相互作用，从而抑制胆固醇吸收。NPC1L1的表达受到多个核因子如PPARs，LXRα，SREBP2，HNF4α的调控；另一方面，NPC1L1又能够通过调节细胞胆固醇水平，进而调控胆固醇代谢相关的SREBP1c、FAS和ABCA1等基因，进一步维持体内胆固醇的动态平衡。多种中药对胆固醇吸收有抑制作用 ...
openaire   +1 more source

Association between Lipid-Lowering Drugs and Traumatic Subdural Hemorrhage: A Mendelian Randomization Study

Journal of Integrative Neuroscience
Background: There are current clinical observations that atorvastatin may promote subdural hematoma resorption. We aimed to assess the causal effects of lipid-lowering agents 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) inhibitors ...
Kaiqin Chen, He Li, Yongtai Chen, Hesen Huang, Liangfeng Wei   +4 more
doaj   +1 more source

Inhibition of Ebola Virus Infection: Identification of Niemann-Pick C1 as the Target by Optimization of a Chemical Probe

, 2016
A high-throughput screen identified adamantane dipeptide 1 as an inhibitor of Ebola virus (EboV) infection. Hit-to-lead optimization to determine the structure–activity relationship (SAR) identified the more potent EboV inhibitor 2 and a photoaffinity ...
James Cunningham (1993180), Anna Bruchez (1993183), John Misasi (1993177), Marceline Côté (1993186), Kyungae Lee (173982), Tao Ren (72849), Berahman Gholamreza (1993189)   +6 more
core   +1 more source

Additive Effects of Ezetimibe and Statins in Managing Elevated LDL-C: An Approach to Reducing Cardiovascular Risk [PDF]

Journal of Advanced Biomedical Sciences
Elevated low-density lipoprotein cholesterol (LDL-C) is a key modifiable risk factor for cardiovascular disease. While statins are the cornerstone of LDL-C-lowering therapy, their long-term use may result in dose-dependent adverse effects.
Narges Yaghoobi, Mojtaba Farjam, Babak Pezeshki   +2 more
doaj  

Gender dimorphism in siblings with schizophrenia-like psychosis due to Niemann-Pick disease type C

, 2009
Gender dimorphism in siblings with schizophrenia-like psychosis due to Niemann-Pick disease type
M Walterfang (13387071), R Mocellin (13479919), E Bowman (13478836), M Fietz (13479907), Larry Abel (13056207), D Velakoulis (10456577)   +5 more
core