Results 101 to 110 of about 115,838,581 (186)

Hydroxyurea ameliorates atherosclerosis in ApoE^-/- mice by potentially modulating Niemann-Pick C1-like 1 protein through the gut microbiota. [PDF]

Theranostics, 2022
Yang XY, Yu H, Fu J, Guo HH, Han P, Ma SR, Pan LB, Zhang ZW, Xu H, Hu JC, Zhang HJ, Bu MM, Zhang XF, Yang W, Wang JY, Jin JY, Zhang HC, Li DR, Lu JY, Lin Y, Jiang JD, Tong Q, Wang Y.   +22 more
europepmc   +1 more source

Long term substrate reduction therapy with ezetimibe alone or associated with statins in three adult patients with lysosomal acid lipase deficiency

Orphanet Journal of Rare Diseases, 2018
Background Lysosomal acid lipase deficiency is an autosomal recessive metabolic disease with a wide range of severity from Wolman Disease to Cholesterol Ester Storage Disease. Recently enzyme replacement therapy with sebelipase alpha has been approved by
Maja Di Rocco, Livia Pisciotta, Annalisa Madeo, Marta Bertamino, Stefano Bertolini   +4 more
doaj   +1 more source

Dietary cholesterol induces trafficking of intestinal Niemann-Pick Type C1 Like 1 from the brush border to endosomes

, 2011
The transmembrane protein Niemann-Pick C1 Like 1 (NPC1L1) belongs to the Niemann-Pick C1 (NPC1) family of cholesterol transporters and is mainly expressed in the liver and the small intestine. NPC1L1 is believed to be the main transporter responsible for
Marianne Skov, Gert H. Hansen, Hansen, Gert H, Carina K. Tønnesen, E. Michael Danielsen, Tønnesen, Carina K, Danielsen, E Michael, Skov, Marianne   +7 more
core   +1 more source

Neurological Dysfunction in Early Maturity of a Model for Niemann–Pick C1 Carrier Status [PDF]

, 2016
Autosomal recessive inheritance of NPC1 with loss-of-function mutations underlies Niemann-Pick disease, type C1 (NP-C1), a lysosomal storage disorder with progressive neurodegeneration.
Velakoulis, D, Bray, L, Jacobson, LH, Churilov, L, Bush, AI, Walterfang, M, Jones, NC, O’Brien, TJ, Hung, YH, Barnham, KJ   +9 more
core   +1 more source

The summary of study design.

NPC1L1, Niemann-Pick C1-like protein 1; ABCA1, ATP Binding Cassette Subfamily A Member 1; ANGPTL3, angiopoietin-like 3.
Zhican Huang (18071525), Haiyan Zhou (405123), Yutong Wu (3130584), Jin Yao (486694), Jun Zhu (84054), Xin Yang (104842), Li Cui (37567), Ting Cui (673336)   +7 more
core   +1 more source

Expression of the hepatic Niemann-Pick C1 like 1 protein gene is sensitive to rosuvastatin treatment of primary human hepatocytes

, 2010
Statins act by reducing hepatic cholesterol synthesis, thus stimulating uptake of serum cholesterol. Statin therapy modulates a number of genes involved in hepatic cholesterol homeostasis.
Deakin, Sara Patricia, Sgroi, Antonino, James, Richard William, Brulhart-Meynet, Marie-Claude, Buehler, Leo Hans, Leo Buhler, Richard William James, Sara P. Deakin, Antonino Sgroi, Marie-Claude Brulhart-Meynet   +9 more
core   +1 more source

THE ROLE OF NIEMANN-PICK C1-LIKE 1 (NPC1L1) PROTEIN IN CHOLESTEROL TRANSPORT AND METABOLIC DISEASES

, 2010
Niemann-Pick C1-Like 1 (NPC1L1) is a polytopic transmembrane protein critical for intestinal absorption of dietary and biliary cholesterol. Ezetimibe, by inhibiting NPC1L1 function, is widely used to lower blood cholesterol in humans.
Jia, Lin
core  

Luteolin prevents cholesterol gallstone formation in mice by downregulating NRF2-mediated NPC1L1 expression

Food Science and Human Wellness
Luteolin, a flavonoid that has been developed for commercial use in health supplements and cosmetics, has the potential to treat hypercholesterolemia. Gallstone disease is a common disease worldwide.
Qihan Wang, Weiyi Shen, Wentao Shao, Zhaoyan Jiang, Gang Zhao, Hai Hu   +5 more
doaj   +1 more source

Stem cells in Niemann-Pick disease [PDF]

, 2008
Neural stem cells are multi-potent and able to self renew to maintain its character throughout the life. Loss of self renewal ability of stem cells prevents recovery or replacement of cells damaged by disease with new cells.
Kim, Sun-Jung, Park, Joon-Suk, Kang, Kyung-Sun   +2 more
core  

Ezetimibe Anticancer Activity via the p53/Mdm2 Pathway

Biomedicines
Background: Ezetimibe is used to treat cardiovascular disease as it blocks the sterol transporter Niemann-Pick C1-Like 1 (NPC1CL1) protein. However, recent evidence indicates that Ezetimibe inhibits several cancers indirectly by reducing circulating ...
Charmy Twala, Sibusiso Malindisa, Chamone Munnik, Selisha Sooklal, Monde Ntwasa   +4 more
doaj   +1 more source