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Ergosterol as a natural modulator of intestinal cholesterol absorption via NPC1L1: an in silico insight into hypercholesterolemia [PDF]

Frontiers in Bioinformatics
IntroductionCardiovascular disease (CVD) is the leading cause of death worldwide and is substantially caused by high cholesterol levels. High levels of low-density lipoprotein cholesterol (LDL-C) lead to atherosclerosis, which greatly raises the risk of ...
Aparna G. Shenoy, Amrithesh Sureshkumar, Vishal Ravi, Rajesh Raju, Niyas Rehman   +4 more
doaj   +2 more sources

The Role of NPC1L1 in Cancer

Frontiers in Pharmacology, 2022
Lipid metabolism appears to play significant roles in the development of cancer. Numerous studies have shown that the evolution of malignancies, including breast, prostate, and colorectal cancers, involves cholesterol in a profound manner. A crucial part
Dongming Xing, Lingyu Shi, Jingsen Meng
exaly   +3 more sources

Effect of Hepatic NPC1L1 on Cholesterol Gallstone Disease and Its Mechanism

Heliyon, 2023
Cholesterol gallstone disease (CGD) is associated with bile cholesterol supersaturation. The Niemann-Pick C1-like 1 (NPC1L1), the inhibitory target of ezetimibe (EZE), is a critical sterol transporter of cholesterol absorption.
Guoqiang Xu, Pingfan Mo
exaly   +3 more sources

Niemann–Pick C1-Like 1 in Cholesterol Absorption and Homeostasis: Mechanisms, Regulation, and Emerging Phytochemical Inhibitors [PDF]

Current Issues in Molecular Biology
Disruption of cholesterol homeostasis is closely associated with hypercholesterolemia, dyslipidemia, atherosclerotic cardiovascular disease (ASCVD), and metabolic disorders such as metabolic dysfunction-associated fatty liver disease (MAFLD).
Pei-Yi Chen, Je-Wen Liou, Ming-Jiuan Wu, Jui-Hung Yen   +3 more
doaj   +2 more sources

First Discovery of Cholesterol-Lowering Activity of Parthenolide as NPC1L1 Inhibitor

Molecules, 2022
Elevated cholesterol significantly increases the risk of developing atherosclerosis and coronary heart disease. The key to treating hypercholesterolemia is lowering plasma cholesterol levels.
Lingyu Shi, Jingsen Meng, Huanting Li
exaly   +3 more sources

Dual functions of NPC1L1 for cholesterol transport: Cholesterol capture and regulation of inner-leaflet cholesterol accessibility [PDF]

iScience
Summary: Niemann-Pick C1-like 1 (NPC1L1) is essential for intestinal cholesterol absorption, but the detailed mechanisms underlying its non-vesicular cholesterol transport remain unclear.
Yoshihide Yamanashi, Maiko Kitani, Megumi Kumamaru, Tomoki Fukaya, Rina Sugita, Tappei Takada   +5 more
doaj   +2 more sources

Dietary curcumin prevents hypercholesterolemia by inhibiting the transcriptional activity of SREBP-2 and HNF1α and reducing intestinal and hepatic NPC1L1 expression in high-fat diet-fed hamsters [PDF]

Nutrition & Metabolism
Background Niemann-Pick C1-like 1 (NPC1L1) mediates cholesterol absorption and plays major roles in cholesterol homeostasis. Our previous study showed that curcumin reduced NPC1L1 expression and cholesterol absorption in Caco-2 cells. This study aimed to
Zhuo Cao, Jie Yang, Haiyan Mai, Ting Hong, Xiaobing Chen, Dan Feng   +5 more
doaj   +2 more sources

Genetic association analysis between LDL-c lowering drugs and portal hypertension using Mendelian randomization analysis [PDF]

Scientific Reports
Clinical guidelines recommend the use of statins to reduce portal pressure and alleviate portal hypertension (PH). However, there is a lack of population-level studies on the use of non-statin Low-Density Lipoprotein Cholesterol (LDL-c) reduction agents ...
Qing-Ao Xiao, Xiao-Long Li, Lei Qin, Xiao-Lin Zhang   +3 more
doaj   +2 more sources

In Silico Analysis of the NPC1L1 Inhibitor of Catechins from Green Tea

Jurnal Info Kesehatan, 2023
The main contributor to cardiovascular disease is atherosclerosis. The Liver X Receptor is one of the unexplored signaling pathways in atherosclerosis that contributes to cholesterol efflux and inhibitory inflammation (LXR).
Erna Susanti, Ellyvına Setyadini
doaj   +1 more source

FGF15 promotes hepatic NPC1L1 degradation in lithogenic diet-fed mice

Lipids in Health and Disease, 2022
Background Cholesterol gallstone disease (CGD) is accompanied by biliary cholesterol supersaturation. Hepatic Niemann-Pick C1-like 1 (NPC1L1), which is present in humans but not in wild-type (WT) mice, promotes hepatocyte cholesterol uptake and decreases
Pingfan Mo, Hongtan Chen, Xin Jiang, Fengling Hu, Fenming Zhang, Guodong Shan, Wenguo Chen, Sha Li, Yiqiao Li, Guoqiang Xu   +9 more
doaj   +1 more source