FGF15 promotes hepatic NPC1L1 degradation in lithogenic diet-fed mice [PDF]
Lipids in Health and Disease, 2022 Background Cholesterol gallstone disease (CGD) is accompanied by biliary cholesterol supersaturation. Hepatic Niemann-Pick C1-like 1 (NPC1L1), which is present in humans but not in wild-type (WT) mice, promotes hepatocyte cholesterol uptake and decreases
Pingfan Mo +9 more
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Frontiers in Pharmacology, 2022 Lipid metabolism appears to play significant roles in the development of cancer. Numerous studies have shown that the evolution of malignancies, including breast, prostate, and colorectal cancers, involves cholesterol in a profound manner. A crucial part
Renshuai Zhang
exaly +5 more sources
Curcumin inhibits cholesterol uptake in Caco-2 cells by down-regulation of NPC1L1 expression [PDF]
Lipids in Health and Disease, 2010 Background Curcumin is a polyphenol and the one of the principle curcuminoids of the spice turmeric. Its antioxidant, anti-cancer and anti-inflammatory effects have been intensively studied. Previous in vivo studies showed that administration of curcumin
Duan Rui-Dong, Ohlsson Lena, Feng Dan
doaj +7 more sources
Cloning, phylogenetic analysis, tissue expression profiling, and functional roles of NPC1L1 in chickens, quails, and ducks [PDF]
Poultry ScienceThe Niemann-Pick C1-Like 1 (NPC1L1) protein, primarily expressed in the epithelial cells of the small intestine, is essential for cholesterol absorption from both dietary intake and biliary secretion.
Xin Shu +7 more
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Niemann-Pick C1 (NPC1)/NPC1-like1 Chimeras Define Sequences Critical for NPC1’s Function as a Filovirus Entry Receptor [PDF]
Viruses, 2012 We recently demonstrated that Niemann-Pick C1 (NPC1), a ubiquitous 13-pass cellular membrane protein involved in lysosomal cholesterol transport, is a critical entry receptor for filoviruses.
Esther Ndungo +7 more
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Lipids in Health and Disease, 2005 Background NPC1L1 encodes a putative intestinal sterol transporter which is the likely target for ezetimibe, a new type of lipid-lowering medication.
Guy Justin +3 more
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Nature Communications, 2023 Niemann-Pick C1-like 1 (NPC1L1) is essential for intestinal cholesterol absorption. Together with the cholesterol-rich and Flotillin-positive membrane microdomain, NPC1L1 is internalized via clathrin-mediated endocytosis and transported to endocytic ...
Jian Xiao, Chang Xie, Weiping J Zhang
exaly +2 more sources
NPC1L1 Drives Osteoporosis by Activating the C/EBPα/Cyp27a1/27‐Hydroxycholesterol Axis: A Novel Therapeutic Target for Bone Loss [PDF]
FASEB BioAdvancesThis study investigated how NPC1L1, a cholesterol transporter, regulates osteogenic differentiation through cholesterol metabolism independently of its transport function.
Bohao Li +9 more
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Genetic inactivation of NPC1L1 protects against sitosterolemia in mice lacking ABCG5/ABCG8 [PDF]
Journal of Lipid Research, 2009 Mice lacking Niemann-Pick C1-Like 1 (NPC1L1) (NPC1L1−/−mice) exhibit a defect in intestinal absorption of cholesterol and phytosterols. However, wild-type (WT) mice do not efficiently absorb and accumulate phytosterols either.
Weiqing Tang +5 more
doaj +2 more sources
Localization and role of NPC1L1 in cholesterol absorption in human intestine [PDF]
Journal of Lipid Research, 2006 Recent studies have documented the presence of Niemann-Pick C1-Like 1 (NPC1L1) in the small intestine and its capacity to transport cholesterol in mice and rats.
Alain Théophile Sané +7 more
doaj +2 more sources