Results 11 to 20 of about 4,731 (194)
The structure of the NPC1L1 N-terminal domain in a closed conformation. [PDF]
PLoS ONE, 2011 NPC1L1 is the molecular target of the cholesterol lowering drug Ezetimibe and mediates the intestinal absorption of cholesterol. Inhibition or deletion of NPC1L1 reduces intestinal cholesterol absorption, resulting in reduction of plasma cholesterol ...
Hyock Joo Kwon +2 more
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NPC1L1 and cholesterol transport [PDF]
FEBS Letters, 2010 The polytopic transmembrane protein, Niemann–Pick C1‐Like 1 (NPC1L1), is enriched in the apical membrane of small intestine absorptive enterocytes where it mediates extracellular sterol transport across the brush border membrane. It is essential for intestinal sterol absorption and is the molecular target of ezetimibe, a potent cholesterol absorption ...
Betters, Jenna L., Yu, Liqing
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Ezetimibe Blocks Internalization of the NPC1L1/Cholesterol Complex [PDF]
Cell Metabolism, 2008 Niemann-Pick C1-like 1 (NPC1L1) is a target for ezetimibe, a drug that blocks intestinal cholesterol absorption. A new study by Ge et al. (2008) in this issue of Cell Metabolism shows that non-lipoprotein-bound cholesterol induces endocytosis of NPC1L1 and that ezetimibe blocks the internalization of the NPC1L1/cholesterol complex.
Chang, Ta-Yuan, Chang, Catherine
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Journal of Lipid Research, 2008 Niemann-Pick C1-like 1 (NPC1L1) is a recently identified protein that mediates intestinal cholesterol absorption and regulates biliary cholesterol excretion. The itineraries and kinetics of NPC1L1 trafficking remain uncertain.
Nicole Hartwig Petersen +3 more
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Fomiroid A, a novel compound from the mushroom Fomitopsis nigra, inhibits NPC1L1-mediated cholesterol uptake via a mode of action distinct from that of ezetimibe. [PDF]
PLoS ONE, 2014 Hypercholesterolemia is one of the key risk factors for coronary heart disease, a major cause of death in developed countries. Suppression of NPC1L1-mediated dietary and biliary cholesterol absorption is predicted to be one of the most effective ways to ...
Tomohiro Chiba +8 more
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SREBP2 mediates the modulation of intestinal NPC1L1 expression by curcumin [PDF]
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2011 Curcumin, the major phenolic compound in the spice turmeric, exhibits numerous biological effects, including lowering plasma cholesterol and preventing diet-induced hypercholesterolemia. The mechanisms underlying the hypocholesterolemic effect of curcumin are not fully understood.
Pradeep, Kumar +8 more
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The NPC1L1 Polymorphism 1679C>G Is Associated with Gallstone Disease in Chinese Patients. [PDF]
PLoS ONE, 2016 Niemann Pick Type C1 Like 1 (NPC1L1) protein plays a key role in intestinal and hepatic cholesterol metabolism in humans. Genetic variation in NPC1L1 has been widely studied in recent years.
Jian Wu +7 more
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Localization and role of NPC1L1 in cholesterol absorption in human intestine [PDF]
Journal of Lipid Research, 2006 Recent studies have documented the presence of Niemann-Pick C1-Like 1 (NPC1L1) in the small intestine and its capacity to transport cholesterol in mice and rats.
Alain Théophile Sané +7 more
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NPC1L1 knockout protects against colitis-associated tumorigenesis in mice [PDF]
BMC Cancer, 2015 Colorectal cancer is strongly associated with lipid metabolism. NPC1L1, a sterol transporter, plays a key role in modulating lipid homeostasis in vivo. Its inhibitor, ezetimibe, began to be used clinically to lower cholesterol and this caused the great debate on its role in causing carcinogenesis.
He, Jianming +5 more
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Curcumin inhibits cholesterol uptake in Caco-2 cells by down-regulation of NPC1L1 expression [PDF]
Lipids in Health and Disease, 2010 Background Curcumin is a polyphenol and the one of the principle curcuminoids of the spice turmeric. Its antioxidant, anti-cancer and anti-inflammatory effects have been intensively studied. Previous in vivo studies showed that administration of curcumin
Duan Rui-Dong, Ohlsson Lena, Feng Dan
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