Inactivating Mutations in NPC1L1 and Protection from Coronary Heart Disease [PDF]
New England Journal of Medicine, 2014 Background Ezetimibe lowers plasma levels of low-density lipoprotein (LDL) cholesterol by inhibiting the activity of the Niemann–Pick C1-like 1 (NPC1L1) protein.
Eric S. Lander
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Decreased NPC1L1 expression in the liver from Chinese female gallstone patients [PDF]
Lipids in Health and Disease, 2010 Background Cholesterol gallstone disease is a very common disease in both industrialized and developing countries. Many studies have found that cholesterol gallstones are more common in women than men. The molecular mechanisms underlying the relationship
Zhang Sheng-Dao +8 more
doaj +3 more sources
Dietary curcumin prevents hypercholesterolemia by inhibiting the transcriptional activity of SREBP-2 and HNF1α and reducing intestinal and hepatic NPC1L1 expression in high-fat diet-fed hamsters [PDF]
Nutrition & MetabolismBackground Niemann-Pick C1-like 1 (NPC1L1) mediates cholesterol absorption and plays major roles in cholesterol homeostasis. Our previous study showed that curcumin reduced NPC1L1 expression and cholesterol absorption in Caco-2 cells. This study aimed to
Zhuo Cao +5 more
doaj +2 more sources
HNF1α and SREBP2 are important regulators of NPC1L1 in human liver [PDF]
Journal of Lipid Research, 2010 Niemann-Pick C1-like 1 (NPC1L1), a key regulator of intestinal cholesterol absorption, is highly expressed in human liver. Here, we aimed to gain more insight into mechanisms participating in its hepatic regulation in humans.
Camilla Pramfalk +7 more
doaj +2 more sources
Inter-domain dynamics drive cholesterol transport by NPC1 and NPC1L1 proteins
eLife, 2020 Transport of LDL-derived cholesterol from lysosomes into the cytoplasm requires NPC1 protein; NPC1L1 mediates uptake of dietary cholesterol. We introduced single disulfide bonds into NPC1 and NPC1L1 to explore the importance of inter-domain dynamics in ...
Piyali Saha +8 more
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Effect of hepatic NPC1L1 on cholesterol gallstone disease and its mechanism
Heliyon, 2023 Cholesterol gallstone disease (CGD) is associated with bile cholesterol supersaturation. The Niemann-Pick C1-like 1 (NPC1L1), the inhibitory target of ezetimibe (EZE), is a critical sterol transporter of cholesterol absorption.
Pingfan Mo +8 more
doaj +3 more sources
Association of NPC1L1 and HMGCR gene polymorphisms with coronary artery calcification in patients with premature triple-vessel coronary disease [PDF]
BMC Medical GenomicsBackground Coronary artery calcification (CAC) is a highly specific marker of atherosclerosis. Niemann-Pick C1-like 1 (NPC1L1) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) are the therapeutic targets of ezetimibe and statins, respectively,
Yulong Li +16 more
doaj +2 more sources
Genetic association analysis between LDL-c lowering drugs and portal hypertension using Mendelian randomization analysis [PDF]
Scientific ReportsClinical guidelines recommend the use of statins to reduce portal pressure and alleviate portal hypertension (PH). However, there is a lack of population-level studies on the use of non-statin Low-Density Lipoprotein Cholesterol (LDL-c) reduction agents ...
Qing-Ao Xiao +3 more
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Niemann–Pick C1-like 1 as a Prognostic Marker in Renal Cell Carcinoma: A Retrospective Cohort Study [PDF]
LifeBackground: Renal cell carcinoma (RCC) is a highly aggressive malignancy accounting for the majority of kidney cancers. Despite recent advancements in therapeutic options, the prognosis for advanced-stage RCC remains poor. Niemann–Pick C1-Like 1 (NPC1L1)
Ryuk Jun Kwon +16 more
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Modulating NPC1L1 to Potentiate PARP Inhibitor-Induced Ferroptosis and Immune Response in Triple-Negative Breast Cancer [PDF]
PharmaceuticsBackground/Objectives: Poly (ADP-ribose) polymerase (PARP) inhibitors have shown significant efficacy in treating BRCA-mutated cancers; however, a significant proportion of patients fail to respond.
Ge Li, Yuxia Yuan, Xinhua Wu, Lixian Wu
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