Inhibitory Effect of Isoliquiritigenin in Niemann-Pick C1-Like 1-Mediated Cholesterol Uptake
Molecules, 2022 Isoliquiritigenin (ISL) is a flavonoid with a chalcone structure extracted from the natural herb Glycyrrhiza glabra. Its anti-inflammatory, antibacterial, antioxidant, and anticancer activities have been extensively studied.
Jun Zeng +9 more
doaj +1 more source
Genetic Variation in NPC1L1 and Risk of Gallstone Disease
Journal of the American College of Cardiology, 2015 We read with great interest the recent paper by Ference et al. [(1)][1] using genetic variants in NPC1L1 (target for ezetimibe) and HMGCR (target for statins) to predict the effect of ezetimibe and statins on low-density lipoprotein (LDL) cholesterol and risk of coronary heart disease ...
Lauridsen, Bo Kobberø +2 more
openaire +3 more sources
Atorvastatin increases intestinal expression of NPC1L1 in hyperlipidemic men [PDF]
Journal of Lipid Research, 2011 Inhibition of cholesterol synthesis by 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoAR) inhibitors has been associated with an increase in intestinal cholesterol absorption. This study examined how HMG-CoAR inhibition by atorvastatin modulates expression of key genes involved in intestinal cholesterol metabolism.
André J. Tremblay +7 more
openaire +3 more sources
HNF1α and SREBP2 are important regulators of NPC1L1 in human liver
Journal of Lipid Research, 2010 Niemann-Pick C1-like 1 (NPC1L1), a key regulator of intestinal cholesterol absorption, is highly expressed in human liver. Here, we aimed to gain more insight into mechanisms participating in its hepatic regulation in humans.
Camilla Pramfalk +7 more
doaj +1 more source
Pharmacological Targets for Periodontitis: A Systematic Review of Drug-Target Mendelian Randomisation Studies. [PDF]
J Periodontal ResThis systematic review evaluated drug‐target Mendelian randomisation studies on periodontitis. Twelve studies identified host‐response‐related targets mainly involved in inflammatory, complement, and immune pathways. Although some targets were linked to existing drugs, the evidence remains preliminary and heterogeneous, requiring replication and ...
Nibali L +4 more
europepmc +2 more sources
Luteolin and quercetin affect the cholesterol absorption mediated by epithelial cholesterol transporter niemann-pick c1-like 1 in caco-2 cells and rats. [PDF]
PLoS ONE, 2014 Niemann-Pick C1-Like 1 (NPC1L1) mediates cholesterol absorption, and ezetimibe is a potent NPC1L1 inhibitor applicable for medication of hypercholesterolemia.
Mari Nekohashi +7 more
doaj +1 more source
, 2020 Niemann-Pick C1-Like 1 (NPC1L1) is a cholesterol importer and target of ezetimibe, a cholesterol absorption inhibitor used clinically for dyslipidemia.
Hideaki Yamamoto +3 more
core +1 more source
Extracellular loop C of NPC1L1 is important for binding to ezetimibe [PDF]
Proceedings of the National Academy of Sciences, 2008 Niemann–Pick C1-like protein (NPC1L1) mediates the absorption of dietary cholesterol in the proximal region of the intestine, a process that is blocked by cholesterol absorption inhibitors (CAIs), including ezetimibe (EZE). Using a proteomic approach, we demonstrate that NPC1L1 is the protein to which EZE and its analogs bind. Next,
Adam B, Weinglass +14 more
openaire +2 more sources
NPC1L1-25hydroxycholesterol Complex
, 2019 Varios sterols binding to NPC1L11) NPC1L1-25-hydroxycholesterol Complex.pdb2) MMPBSA output from trajectory analysis3) Decompose analysis from trajectory analysis4) trajectory analysis: Backbone RMSD, B-factor, Gyration
Daniel Wüstner (7427320) +2 more
core +1 more source
Bisphenol A promotes cholesterol absorption in Caco-2 cells by up-regulation of NPC1L1 expression [PDF]
, 2017 Background Bisphenol A (BPA), an commonly exposed environmental chemicals in humans, has been shown to have a hypercholesterolemic effect with molecular mechanism not clear.
Jun Zou +11 more
core +1 more source