Effects of Lipid-Lowering Drugs on Irisin in Human Subjects In Vivo and in Human Skeletal Muscle Cells Ex Vivo [PDF]
, 2013 Context and Objective The myokine irisin has been proposed to regulate energy homeostasis. Little is known about its association with metabolic parameters and especially with parameters influencing pathways of lipid metabolism.
Berman, Reena +6 more
core +9 more sources
Sequencing of an npc1L1 mutation in larval zebrafish.
Proceedings of the West Virginia Academy of Science, 2019 How the intestinal absorption of lipids impact dyslipidemias such as obesity and diabetes is currently under debate. NPC1L1 is a critical transport protein in enterocyte cholesterol absorption. To understand the mechanism of intestinal NPC1L1 uptake within the enterocyte, we are creating a npc1l1 -/- (knockout) line in zebrafish.
James W. Walters, Jordan Marcelle Smith
openalex +2 more sources
Ezetimibe blocks the internalization of NPC1L1 and cholesterol in mouse small intestine
Journal of Lipid Research, 2012 The multiple transmembrane protein Niemann-Pick C1 like1 (NPC1L1) is essential for intestinal cholesterol absorption. Ezetimibe binds to NPC1L1 and is a clinically used cholesterol absorption inhibitor.
Chang Xie 谢畅 +7 more
doaj +1 more source
Fomiroid A, a novel compound from the mushroom Fomitopsis nigra, inhibits NPC1L1-mediated cholesterol uptake via a mode of action distinct from that of ezetimibe. [PDF]
PLoS ONE, 2014 Hypercholesterolemia is one of the key risk factors for coronary heart disease, a major cause of death in developed countries. Suppression of NPC1L1-mediated dietary and biliary cholesterol absorption is predicted to be one of the most effective ways to ...
Tomohiro Chiba +8 more
doaj +1 more source
Lipids in Health and Disease, 2021 Background Colorectal cancer (CRC) is a malignancy of the large intestine, whose development and prognosis have been demonstrated to be associated with altered lipid metabolism.
Ryuk Jun Kwon +6 more
doaj +1 more source
Molecular actions of hypocholesterolaemic compounds from edible mushrooms [PDF]
, 2018 Cholesterol levels are strictly regulated to maintain its homeostasis; therefore, if it is not absorbed with the diet, the cholesterol biosynthetic pathway is enhanced and vice versa.
Gil-Ramírez, Alicia +2 more
core +1 more source
Duodenal Niemann-Pick C1-like 1 expression was negatively correlated with liver X receptor expression in nonalcoholic fatty liver disease [PDF]
The Korean Journal of Internal Medicine, 2019 Background/Aims Intestinal cholesterol absorption includes intestinal Niemann-Pick C1-like 1 (NPC1L1) and is an important target pathway in nonalcoholic fatty liver disease (NAFLD).
Sang Bong Ahn +4 more
doaj +1 more source
Oligodendroglial Process Formation is Differentially Affected by Modulating the Intra- and Extracellular Cholesterol Content [PDF]
, 2012 Cholesterol is an essential component of eukaryotic plasma membranes and plays an important role in membrane organization and signaling processes. It is the major lipid component of detergent resistant caveolin-1 containing rafts which previously had ...
Hans H. Althaus +3 more
core +1 more source
Inhibitory Effect of Isoliquiritigenin in Niemann-Pick C1-Like 1-Mediated Cholesterol Uptake
Molecules, 2022 Isoliquiritigenin (ISL) is a flavonoid with a chalcone structure extracted from the natural herb Glycyrrhiza glabra. Its anti-inflammatory, antibacterial, antioxidant, and anticancer activities have been extensively studied.
Jun Zeng +9 more
doaj +1 more source
Journal of Biomedical Science, 2023 Background Cholesterol gallstone disease is a common disease. Reducing cholesterol burden is important to prevent/treat gallstone. In this study, we investigated the application of diosgenin (DG) to prevent the formation of gallstone in mice.
Weiyi Shen +7 more
doaj +1 more source