Results 61 to 70 of about 7,302 (251)
Defining the Place of Ezetimibe/Atorvastatin in the Management of Hyperlipidemia [PDF]
, 2016 Statin-ezetimibe combinations are a potentially advantageous therapeutic option for high-risk patients who need additional lowering of low-density lipoprotein cholesterol (LDL-C).
Ferreira, AM, Marques da Silva, P
core +1 more source
Food Frontiers, Volume 7, Issue 3, May 2026.ABSTRACT Fungal polysaccharides (FPs) represent a diverse class of bioactive macromolecules widely studied for their nutritional, therapeutic, and biotechnological value. This review synthesizes recent advances (2020–2025) in the structural characterization, biological functions, and translational potential of FPs.
Muhammad Aaqil +6 more
wiley +1 more source
Hepatitis C virus relies on lipoproteins for its life cycle [PDF]
, 2016 Hepatitis C virus (HCV) infects over 150 million people worldwide. In most cases, HCV infection becomes chronic causing liver disease ranging from fibrosis to cirrhosis and hepatocellular carcinoma.
Alonzi, Tonino +5 more
core +1 more source
Liver Fibrosis: Molecular Pathogenesis and Therapeutic Interventions
MedComm, Volume 7, Issue 5, May 2026.We systematically summarized the etiologies, diagnostic approaches, and pathogenic mechanisms of liver fibrosis. Also, the therapeutic interventions for liver fibrosis were systematically classified into two main categories: etiological treatment and mechanism‐based antifibrotic therapies.
Jiaorong Qu +8 more
wiley +1 more source
Breast Cancer Research, 2022 Background Preclinical and epidemiological studies indicate a potential chemopreventive role of low-density lipoprotein cholesterol (LDL-C) -lowering drugs in the risks of breast cancer and prostate cancer, but the causality remains unclear.
Lulu Sun +9 more
doaj +1 more source
Effect of NPC1L1 and HMGCR Genetic Variants With Premature Triple-Vessel Coronary Disease
Frontiers in Cardiovascular Medicine, 2021 Background: Both Niemann-Pick C1-like 1 (NPC1L1) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) play a key role on dyslipidaemia. We aim to evaluate whether NPC1L1 and HMGCR genetic variants are associated with susceptibility of premature ...
Xueyan Zhao +15 more
doaj +1 more source
Using inactivating mutations to provide insight into drug action [PDF]
, 2015 The role of ezetimibe in lowering plasma cholesterol has been established; however, controversy remains about its clinical benefit. A recent study utilizes naturally occurring genetic variation within the NPC1-like 1 gene (NPC1L1) to demonstrate the ...
Corbin, Laura J, Timpson, Nicholas John
core +3 more sources
Review Article: Targeting Peroxisome Proliferator‐Activated Receptors in Primary Biliary Cholangitis
Alimentary Pharmacology &Therapeutics, Volume 63, Issue 9, Page 1215-1235, May 2026.Peroxisome proliferator‐activated receptor (PPAR) agonists have emerged as important second‐line treatments in primary biliary cholangitis, with profiles influenced by different selectivity for α‐, δ‐ and γ‐isoforms. PPAR‐α and PPAR‐δ agonism improve cholestasis, with inflammation reduced via all isoforms. PPAR‐δ agonism also reduces pruritus.
Jörn M. Schattenberg +8 more
wiley +1 more source
Glycaemic effects of non-statin lipid-lowering therapies [PDF]
, 2016 Since the publication of the JUPITER trial, attention has been focused on the adverse glycemic effects of statin therapy. Although the modest increase in the risk of new diabetes mellitus is outweighed by the reduction in cardiovascular events for ...
Collins, Patrick D., Sattar, Naveed
core +1 more source
Aquaculture, Fish and Fisheries, Volume 6, Issue 2, April 2026.Probiotics offer a promising alternative to antibiotics for managing Aeromonas hydrophila infections in aquaculture. Dietary supplementation of probiotics increases fish health, growth performance, and immune responses, while reducing antibiotic reliance in fish farming.
Md. Ridwanul Islam +3 more
wiley +1 more source