Results 61 to 70 of about 4,731 (194)

The Structure of NPC1L1(NTD).

, 2013
(A) NPC1L1(NTD) is represented as a ribbon diagram and the disulfide bonds are shown in yellow. Domain A is colored orange (α-helices), cyan (β-sheets), and gray (loops).
Hyock Joo Kwon (353193), Maya Palnitkar (353194), Johann Deisenhofer (54414)   +2 more
core   +1 more source

Monitoring pharmacodynamic and molecular drug targets in liquid biopsy: Exploratory study in liver cancer with modelling of EGFR Receptor engagement

British Journal of Clinical Pharmacology, Volume 92, Issue 11, Page 3902-3913, November 2026.
Abstract Aim Liquid biopsy is minimally invasive (compared with tissue biopsy) and has previously been used to generate systems data regarding drug elimination via hepatic enzymes and transporters. This study extends quantitative assessment of systems parameters in liquid biopsy to pharmacodynamic (PD) and disease markers relevant to cancer development
Zubida M. Al‐Majdoub, Armin Sepp, Amin Rostami‐Hodjegan, Brahim Achour   +3 more
wiley   +1 more source

Cardiovascular and neuropsychiatric outcomes with PCSK9 inhibitors in atherosclerotic cardiovascular disease: A retrospective cohort study

British Journal of Clinical Pharmacology, Volume 92, Issue 11, Page 3862-3873, November 2026.
Study design and main findings. After 1:1 propensity score matching, 60 885 PCSK9 inhibitor users and 60 885 statin‐only users with ASCVD were compared. Kaplan–Meier curves show 12‐month cumulative event‐free survival for MACE, psychiatric disease, and neurodegenerative disease.
Tianshu Gu, Yang Chen, Nan Zhang, Uazman Alam, Riccardo Proietti, Tong Liu, Kang‐Yin Chen, Gregory Y. H. Lip   +7 more
wiley   +1 more source

Associations of genetically proxied inhibition of HMG-CoA reductase, NPC1L1, and PCSK9 with breast cancer and prostate cancer

Breast Cancer Research, 2022
Background Preclinical and epidemiological studies indicate a potential chemopreventive role of low-density lipoprotein cholesterol (LDL-C) -lowering drugs in the risks of breast cancer and prostate cancer, but the causality remains unclear.
Lulu Sun, Huan Ding, Yiming Jia, Mengyao Shi, Daoxia Guo, Pinni Yang, Yu Wang, Fanghua Liu, Yonghong Zhang, Zhengbao Zhu   +9 more
doaj   +1 more source

NPC1L1(NTD) in a closed conformation.

, 2013
(A) The surface of NPC1L1(NTD), colored green, reveals a cholesterol binding pocket (blue) that is closed to solvent. (B) The surface of NPC1(NTD), colored gray, shows the cholesterol binding pocket (yellow) exposed to solvent. The isooctyl side chain of
Hyock Joo Kwon (353193), Maya Palnitkar (353194), Johann Deisenhofer (54414)   +2 more
core   +1 more source

Niemann–Pick C1-like 1 as a Prognostic Marker in Renal Cell Carcinoma: A Retrospective Cohort Study

Life
Background: Renal cell carcinoma (RCC) is a highly aggressive malignancy accounting for the majority of kidney cancers. Despite recent advancements in therapeutic options, the prognosis for advanced-stage RCC remains poor. Niemann–Pick C1-Like 1 (NPC1L1)
Ryuk Jun Kwon, Ho Jun Kim, Young-Shin Lee, Hye Sun Lee, Sang Yeoup Lee, Eun-Ju Park, Youngin Lee, Sae Rom Lee, Jung-In Choi, Soo Min Son, Jeong Gyu Lee, Yu Hyeon Yi, Young Jin Tak, Seung-Hun Lee, Gyu Lee Kim, Young Jin Ra, Young Hye Cho   +16 more
doaj   +1 more source

NPC1L1-dependent intestinal cholesterol absorption requires ganglioside GM3 in membrane microdomains

Journal of Lipid Research, 2018
Intestinal cholesterol absorption is a key regulator of systemic cholesterol homeostasis. Excessive dietary cholesterol and its intestinal uptake lead to hypercholesterolemia, a major risk factor for cardiovascular disease.
Wataru Nihei, Masakazu Nagafuku, Hirotaka Hayamizu, Yuta Odagiri, Yumi Tamura, Yui Kikuchi, Lucas Veillon, Hirotaka Kanoh, Kei-ichiro Inamori, Kenta Arai, Kazuya Kabayama, Koichi Fukase, Jin-ichi Inokuchi   +12 more
doaj   +1 more source

Effect of NPC1L1 and HMGCR Genetic Variants With Premature Triple-Vessel Coronary Disease

Frontiers in Cardiovascular Medicine, 2021
Background: Both Niemann-Pick C1-like 1 (NPC1L1) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) play a key role on dyslipidaemia. We aim to evaluate whether NPC1L1 and HMGCR genetic variants are associated with susceptibility of premature ...
Xueyan Zhao, Jingjing Xu, Xiaofang Tang, Keyong Huang, Jiawen Li, Ru Liu, Lin Jiang, Yin Zhang, Dong Wang, Kai Sun, Bo Xu, Wei Zhao, Rutai Hui, Runlin Gao, Lei Song, Jinqing Yuan   +15 more
doaj   +1 more source

Meroterpenoids Produced by Fungi: Occurrence, Structural Diversity, and Biological Activity (An Update: February 2020 to December 2025)

Chemistry &Biodiversity, Volume 23, Issue 11, November 2026.
This review firstly summarizes the update of meroterpenoids from February 2020 to December 2025 by applying a new classification method based on twelve key non‐terpene precursors. ABSTRACT Meroterpenoids are a class of hybrid natural products, biosynthesized from terpenoid fragments and non‐terpenoid precursors, exhibiting a wide range of biological ...
Yuqian Tang, Jinqin Wei, Zhao Jiang, Yingming Luo, Yan Zhou, Jiafan Yang, Hui Cui   +6 more
wiley   +1 more source

NPC1L1 Drives Osteoporosis by Activating the C/EBPα/Cyp27a1/27‐Hydroxycholesterol Axis: A Novel Therapeutic Target for Bone Loss

FASEB BioAdvances
This study investigated how NPC1L1, a cholesterol transporter, regulates osteogenic differentiation through cholesterol metabolism independently of its transport function.
Bohao Li, Wuling Zhou, Yueming Yu, Boyu Chen, Zhicheng Lv, Jiarui Zhang, Tieqi Zhang, Shiwei Sun, Lei Zhou, Minghai Wang   +9 more
doaj   +1 more source