Results 81 to 90 of about 4,731 (194)

Investigation of NPC1L1 and NPC2 Protein Levels in Patients with Cholelithiasis: Implications for Cholesterol Transport and Gallbladder Inflammation

Cumhuriyet Science Journal
Cholelithiasis is a common hepatobiliary disorder associated with impaired cholesterol homeostasis and chronic inflammation. Niemann–Pick C1-Like 1 (NPC1L1) and Niemann–Pick C2 (NPC2) are proteins involved in cholesterol transport; however, their roles ...
Hüsnü Çağrı Genç, Hakkı Coşkun, Cemile Zontul, Ayça Taş, Ömer Topcu, Yavuz Siliğ   +5 more
doaj   +1 more source

Early‐Onset Prostate Cancer: Epidemiology, Risk Factors, Biology, Clinical Features, Management, and Early Detection

MedComm, Volume 7, Issue 8, August 2026.
EOPC is a distinct clinicopathological entity separable from SOPC, differing fundamentally in genetic susceptibility, TMPRSS2:ERG fusion frequency, and survival outcomes. Although research remains nascent, this review provides the first comprehensive synthesis of current evidence, offering a critical foundation to guide future investigations into this ...
Xingyu Xiong, Weizhen Zhu, Weichao Huang, Shiyu Zhang, Qi Deng, Jie Yang, Hang Xu, Qiang Wei, Lu Yang   +8 more
wiley   +1 more source

Medications That Regulate Pregnane X Receptor: A Systematic Review of Current Evidence

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
PRISMA 2020 flow diagram of study selection for this systematic review of medications that regulate the pregnane X receptor (PXR), from 12 236 records screened to 101 included studies. ABSTRACT The pregnane X receptor (PXR) gene encodes a ligand‐activated protein involved with the metabolism and excretion of drugs, toxins, and other xenobiotics.
Petra Czarniak, Rachael Moorin, Jeff Hughes, Karl Gruber, David Youens   +4 more
wiley   +1 more source

NPC1L1 Plays a Novel Role in Nonalcoholic Fatty Liver Disease

, 2023
Niemann-Pick C1-Like 1 (NPC1L1) is a key protein in the transport of cholesterol, which exists in the brush marginal membrane of the intestinal epithelial cells and the timid duct membrane of the liver.
Yuhan She (17628518), Fengyang Fu (284795), ChongBo Xu (17628521), ChongLi Xu (17628515)   +3 more
core   +1 more source

LASP1, a Novel Protein in Spermatozoa and Acrosome Reaction

Molecular Reproduction and Development, Volume 93, Issue 7, July 2026.
LASP1 is expressed in spermatozoa, binds to F‐actin, and builds up the equatorial ring structure during acrosome reaction, which is important for hyaluronan receptor surface presentation. ABSTRACT LIM and SH3 protein 1 (LASP1) is a widely expressed scaffold protein associated with actin‐rich structures. In Lasp1‐knockout mice, reproductive defects such
Alicia Bender, Kilian Andress, Michael R. Boesl, Claudia Staib, Adriane Woehl‐Wenigerkind, Burkhard Kneitz, Hendrik Bartolomaeus, Alma Zernecke, Elke Butt   +8 more
wiley   +1 more source

Ezetimibe interferes with cholesterol trafficking from the plasma membrane to the endoplasmic reticulum in CaCo-2 cells

Journal of Lipid Research, 2007
Niemann-Pick C1-like 1 protein (NPC1L1) is the putative intestinal sterol transporter and the molecular target of ezetimibe, a potent inhibitor of cholesterol absorption.
F. Jeffrey Field, Kim Watt, Satya N. Mathur   +2 more
doaj   +1 more source

Moderate Intensity Statins Plus Ezetimibe Combination Therapy Versus High Intensity Statins Monotherapy After Percutaneous Coronary Intervention: A Systematic Review and Meta‐Analysis

Clinical Cardiology, Volume 49, Issue 6, June 2026.
ABSTRACT Background High‐intensity statins are standard therapy after percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS), yet tolerability concerns and residual cardiovascular risk remain important challenges. Moderate‐intensity statin therapy combined with ezetimibe has emerged as a potential alternative, although its ...
Emad Uddin Sajid, Muhammad Hasnain Azeem, Alishba Fatima, Syeda Masooma Jafri, Danish Hassan, Taha Ibrahim, Kashish Zehra Manjee, Syed Rayyan Ahmed, Tooba Ali, Rida Shakeel, Muhammad Usman, Raghabendra Kumar Mahato, Danish Bawa   +12 more
wiley   +1 more source

Niemann-Pick C1-Like 1 deletion in mice prevents high-fat diet-induced fatty liver by reducing lipogenesis[S]

Journal of Lipid Research, 2010
Niemann-Pick C1-Like 1 (NPC1L1) mediates intestinal absorption of dietary and biliary cholesterol. Ezetimibe, by inhibiting NPC1L1 function, is widely used to treat hypercholesterolemia in humans.
Lin Jia, Yinyan Ma, Shunxing Rong, Jenna L. Betters, Ping Xie, Soonkyu Chung, Nanping Wang, Weiqing Tang, Liqing Yu   +8 more
doaj   +1 more source

Bibliometric Analysis of Cubebenes and Related Sesquiterpenes: Natural Occurrence, Biosynthesis, Pharmacological Activities, and In‐Silico‐Based Future Therapeutic Potential

eFood, Volume 7, Issue 3, June 2026.
Cubebene‐related sesquiterpenes, found across diverse biological sources, exhibit promising pharmacological activities, including anti‐inflammatory, neuroprotective, and anticancer effects. This review highlights their molecular diversity, ADME profiles, and predicted multitarget interactions, underscoring their therapeutic relevance and potential in ...
Khadija Boualam, Ahmet B. Ortaakarsu, Sohaib Khatib, Mohamed A. Farag, Mansour Sobeh   +4 more
wiley   +1 more source

Niemann-Pick C1-Like 1 (NPC1L1) Protein in Intestinal and Hepatic Cholesterol Transport

, 2011
Increased blood cholesterol is an independent risk factor for atherosclerotic cardiovascular disease. Cholesterol homeostasis in the body is controlled mainly by endogenous synthesis, intestinal absorption, and hepatic excretion. Niemann-Pick C1-Like 1 (
Lin Jia, Jenna L. Betters, Liqing Yu
core   +1 more source