Results 71 to 80 of about 4,731 (194)

Efficacy and Safety of Oral Non‐Statin Lipid‐Lowering Therapies in Dyslipidaemia: A Systematic Review and Network Meta‐Analysis

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 6, November 2026.
A network meta‐analysis of 43 randomized trials showed that oral combination therapies, particularly obicetrapib plus ezetimibe and bempedoic acid plus ezetimibe, achieved the greatest LDL‐C reduction with reassuring safety profiles, supporting their use as effective oral alternatives for patients with dyslipidaemia. ABSTRACT Introduction Dyslipidaemia
Tamer Hodrob, Reem J. Saad, Aya Hamdy, Mariam Saleh Alheneedy, Ahmed Mohamed Shehata Abdelfattah Elsayed, Elsaghir Ghazy, Hazem Ayesh   +6 more
wiley   +1 more source

Cryo-EM structures of NPC1L1 reveal mechanisms of cholesterol transport and ezetimibe inhibition

, 2020
The intestinal absorption of cholesterol is mediated by a multipass membrane protein, Niemann-Pick C1-Like 1 (NPC1L1), the molecular target of a cholesterol lowering therapy ezetimibe. While ezetimibe gained Food and Drug Administration approval in 2002,
Huang, Ching-Shin, Fordstrom, Preston, Chung, Ben C., Min, Xiaoshan, Roh, Soung-Hun, Zhou, Mingyue, Wang, Zhulun, Yu, Xinchao, Choi, Kaylee, Chiu, Wah   +9 more
core   +1 more source

Transporters as Drug Targets: Discovery and Development of NPC1L1 Inhibitors

Clinical Pharmacology & Therapeutics, 2009
The potent cholesterol absorption inhibitor ezetimibe was developed as a first-in-class drug for treating hypercholesterolemia even before its molecular target, Niemann-Pick C1-like 1 (NPC1L1), had been identified. The NPC1L1 protein mediates sterol transport across the enterocyte brush border membrane and is essential for intestinal cholesterol ...
Betters, JL, Yu, L
openaire   +2 more sources

NPC1L1: Evolution From Pharmacological Target to Physiological Sterol Transporter [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2006
Niemann-Pick C1-like 1 protein (NPC1L1) was recently shown to be the molecular target of the cholesterol absorption inhibitor class of drugs, of which ezetimibe is the first widely used member. Since its discovery, NPC1L1 has also been shown to play a focal physiological role in intestinal absorption of sterols, including plant sterols and cholesterol.
Murray W, Huff, Rebecca L, Pollex, Robert A, Hegele   +2 more
openaire   +2 more sources

Tropical Plantains, Tubers, and Roots: Advancing Food Quality, Safety, and Processing Innovations for Global Nutritional Equity

Food Science &Nutrition, Volume 14, Issue 11, November 2026.
Plantains, tubers, and roots (PTRs) represent strategic nutritional and caloric pillars for over 500 million people across tropical regions. This review evaluates traditional bioprocessing against eco‐innovative thermomechanical and non‐thermal technologies (HPP, extrusion, encapsulation) to overcome severe post‐harvest losses and antinutritional risks.
Mundéné‐Timothée Junior Lawrence, Veeranna Hitlamani, Njintang Yanou Nicolas, Aashitosh A. Inamdar   +3 more
wiley   +1 more source

Niemann-pick C1-like 1 (NPC1L1) inhibition and cardiovascular diseases [PDF]

, 2016
© 2016 Bentham Science Publishers. Circulating levels of cholesterol are derived from either endogenous production or intestinal absorption of dietary and biliary cholesterol.
A. Pirillo (23447842), A. Catapano (23419033), Giuseppe Norata (23419039)   +2 more
core   +2 more sources

Metabolic Memory in Cardiovascular Disease: Encoding, Propagation, and Therapeutic Targeting

Advanced Science, Volume 13, Issue 54, 28 September 2026.
Cardiovascular risk often persists after metabolic abnormalities are corrected. This conceptual Review frames such persistence as metabolic memory, encoded through a narrowing therapeutic window from reversible marks to irreversible damage, with continuous input from peripheral organs.
Cheng Cheng, Minghui Tang, Zhaobo Zhang, Ruoyi Qu, Jianfei Pei, Tian Liu, Siyao Qu, Shilong You, Shenshen Cui, Wenke Wang, Rui Zhao, Yingxian Sun, Naijin Zhang   +12 more
wiley   +1 more source

Stanol esters decrease plasma cholesterol independently of intestinal ABC sterol transporters and Niemann-Pick C1-like 1 protein gene expression

Journal of Lipid Research, 2004
Possible mechanisms for the cholesterol-lowering effects of plant stanol esters were addressed by feeding hamsters diets containing stanol esters, cholesterol, or cholestyramine/lovastatin.
F. Jeffrey Field, Ella Born, Satya N. Mathur   +2 more
doaj   +1 more source

Molecular Mechanism of Absorption, Transport and Metabolic Transformation of Astaxanthin in Aquatic Animals

Reviews in Aquaculture, Volume 18, Issue 4, September 2026.
This manuscript systematically elucidates the molecular mechanisms underlying absorption, transport, and metabolism of Astaxanthin in aquatic animals, through the analysis of biological functions, transport proteins, and enzyme metabolism system. Furthermore, it outlines future molecular research strategies for Astaxanthin, providing a theoretical ...
Huakang Peng, Yihui Du, Qianwen Ding, Dongdong Du, Ruyue Dong, Chao Ran, Zhen Zhang, Yuanyuan Yao, Hui Liang, Ming Li, Nan Wang, Yalin Yang, Zhigang Zhou   +12 more
wiley   +1 more source

NPC1L1 haplotype is associated with inter-individual variation in plasma low-density lipoprotein response to ezetimibe

Lipids in Health and Disease, 2005
Background NPC1L1 encodes a putative intestinal sterol transporter which is the likely target for ezetimibe, a new type of lipid-lowering medication.
Guy Justin, Hegele Robert A, Ban Matthew R, Wang Jian   +3 more
doaj   +1 more source