Results 51 to 60 of about 4,731 (194)

Intestinal Source Control of Lipid Metabolism by Enzyme-Probiotic Encapsulated, Spatiotemporal Crosslinked, and Small Intestine-Adhesive Hydrogel Microspheres. [PDF]

Adv Sci (Weinh)
A thiol‐modified alginate hydrogel microsphere‐encapsulated enzyme‐probiotic biohybrid (AKK‐COD) system has been developed to address the spatiotemporal delivery and colonization challenges of small intestine‐targeted probiotic for lipid metabolism regulation. The system exerts sequential functions of intragastric protection, small intestinal adhesion,
Wu X, Liang W, He S, Chen G, Zhou H, Wang X, Li Y, Wu D, Zheng B, Dou R, Huang R.   +10 more
europepmc   +2 more sources

NIEMANN-PICK C1-LIKE 1 PROTEIN (NPC1L1) FROM GENETICS TO PHARMACOLOGY FOR THE CONTROL OF HYPERCHOLESTEROLAEMIA

, 2022
reservedIn questa tesi ho deciso di seguire il percorso che ha portato, a partire dalla scoperta di una grave e rara malattia, quale la malattia di Niemann-Pick di tipo C, allo studio di una proteina specifica che regola l’assorbimento intestinale del ...
POMARI, CARLOTTA
core  

Structural differences between NPC1L1 and NPC1.

, 2013
(A) In the closed form of NPC1L1(NTD), ASN211 forms a hydrogen bond with ASP208, allowing LEU213 to rotate toward α7. (B) In the cholesterol bound form of NPC1(NTD), ASN198 forms a hydrogen bond with the main chain amine of GLN200, which is rotated away ...
Hyock Joo Kwon (353193), Maya Palnitkar (353194), Johann Deisenhofer (54414)   +2 more
core   +1 more source

Valorization of Citrus Waste for Recovery of Nutritional and Bioactive Compounds: A Comprehensive Review

Future Postharvest and Food, EarlyView.
The various citrus wastes, including the citrus fruit peels, pulp remaining after extraction of juice, and seeds, are the sources of bioactive compounds. The waste parts of oranges, lemons, limes, grapefruits, and mandarins contain the bioactive compounds, flavonoids, ascorbic acid, essential oils, and carotenoids.
Monika, Rhythm Kalsi, Jasleen Kaur Bhasin, Rafeeya Shams, Kshirod Kumar Dash   +4 more
wiley   +1 more source

Use of NBD-cholesterol to identify a minor but NPC1L1-independent cholesterol absorption pathway in mouse intestine

, 2011
The importance of Niemann-Pick C1 Like-1 (NPC1L1) protein in intestinal absorption of dietary sterols, including both cholesterol and phytosterols, is well documented. However, the exact mechanism by which NPC1L1 facilitates cholesterol transport remains
James G. Cash, David Y. Hui, Michelle R. Adams, Eddy Konaniah   +3 more
core   +1 more source

Niemann-Pick C1 (NPC1)/NPC1-like1 Chimeras Define Sequences Critical for NPC1’s Function as a Filovirus Entry Receptor

Viruses, 2012
We recently demonstrated that Niemann-Pick C1 (NPC1), a ubiquitous 13-pass cellular membrane protein involved in lysosomal cholesterol transport, is a critical entry receptor for filoviruses.
Esther Ndungo, John M. Dye, Sean P. Whelan, Melinda Ng, Andrew S. Herbert, Anuja Krishnan, Emily Happy Miller, Kartik Chandran   +7 more
doaj   +1 more source

Impact of incretin analogues on lipid and lipoprotein metabolism in obesity and diabetes

British Journal of Pharmacology, EarlyView.
Abstract Incretin‐based therapies have gained momentum as a key strategy for reducing cardiovascular risk in individuals with obesity and/or type 2 diabetes (T2D). It remains unclear whether the cardiovascular benefits reflect a direct reduction in atherogenic lipoproteins—namely, low‐density lipoproteins (LDL), very low‐density lipoproteins (VLDL) and
Andrea Baragetti, Giuseppe Danilo Norata
wiley   +1 more source

Dyslipidaemia, Chronic Kidney Disease and Diabetes Mellitus: A Triple Threat to Cardiovascular Health

Diabetes, Obesity and Metabolism, Volume 28, Issue 12, Page 10961-10976, December 2026.
ABSTRACT Diabetes mellitus (DM) and chronic kidney disease (CKD) frequently coexist and together create a ‘triple threat’ with dyslipidaemia, enhancing the risk for cardiovascular morbidity and mortality. Diabetic kidney disease (DKD) leads to altered lipid metabolism through insulin resistance, inflammation and oxidative stress resulting in an ...
Ann S. Forrest, Priyanka Majety, Stéphanie B. Mayer, Om P. Ganda   +3 more
wiley   +1 more source

Hepatic NPC1L1 overexpression attenuates alcoholic autophagy in mice

Molecular Medicine Reports, 2019
Alcohol consumption causes liver steatosis in humans. Metabolic disorders of lipids are one of the factors that cause liver steatosis in hepatocytes. Hepatic Niemann‑Pick C1‑like 1 (NPC1L1) regulates lipid homeostasis in mammals. The relationship between NPC1L1 and autophagy in those with a history of alcohol abuse is unclear.
Wang, Youlin, Yang, Pan, Zhang, Bo, Ding, Yao, Lei, Shun, Hou, Yuning, Guan, Xiaoqing, Li, Qingwang   +7 more
openaire   +3 more sources

Cholesterol Biomimetic Fluorescent Probe for the High Signal‐to‐Noise Ratio and Selectivity Imaging of Nonalcoholic Fatty Liver

Aggregate, Volume 7, Issue 11, November 2026.
A cholesterol‐biomimetic AIE probe, TPAS‐PyCHO+, was designed and synthesized for selective imaging of nonalcoholic fatty liver. The probe hijacked NPC1L1‐mediated clathrin‐dependent endocytosis in steatotic hepatocytes, selectively accumulated in lipid droplets, and enabled high signal‐to‐noise ratio imaging of NAFLD in mice.
Kunyi Wang, Guoyang Zhang, Xuefan Guo, Zixuan Zhang, Nan Xiao, Junya Lei, Yulong Jin, Zhuo Wang   +7 more
wiley   +1 more source