Results 51 to 60 of about 7,302 (251)

Lactobacillus plantarum CUL66 can impact cholesterol homeostasis in Caco-2 enterocytes [PDF]

, 2016
Hypercholesterolemia drives the development of cardiovascular disease, the leading cause of mortality in western society. Supplementation with probiotics that interfere with cholesterol metabolism may provide a contribution to disease prevention ...
Calvente, D. Lama, Garaiova, I., Michael, D. R., Moss, Joe W. E., Plummer, S. F., Ramji, Dipak   +5 more
core   +1 more source

Hepatic NPC1L1 overexpression attenuates alcoholic autophagy in mice

Molecular Medicine Reports, 2019
Alcohol consumption causes liver steatosis in humans. Metabolic disorders of lipids are one of the factors that cause liver steatosis in hepatocytes. Hepatic Niemann‑Pick C1‑like 1 (NPC1L1) regulates lipid homeostasis in mammals. The relationship between NPC1L1 and autophagy in those with a history of alcohol abuse is unclear.
Wang, Youlin, Yang, Pan, Zhang, Bo, Ding, Yao, Lei, Shun, Hou, Yuning, Guan, Xiaoqing, Li, Qingwang   +7 more
openaire   +3 more sources

Luteolin and quercetin affect the cholesterol absorption mediated by epithelial cholesterol transporter niemann-pick c1-like 1 in caco-2 cells and rats. [PDF]

PLoS ONE, 2014
Niemann-Pick C1-Like 1 (NPC1L1) mediates cholesterol absorption, and ezetimibe is a potent NPC1L1 inhibitor applicable for medication of hypercholesterolemia.
Mari Nekohashi, Mana Ogawa, Takuo Ogihara, Kyoko Nakazawa, Hisanori Kato, Takumi Misaka, Keiko Abe, Shoko Kobayashi   +7 more
doaj   +1 more source

First Discovery of Cholesterol-Lowering Activity of Parthenolide as NPC1L1 Inhibitor

Molecules, 2022
Elevated cholesterol significantly increases the risk of developing atherosclerosis and coronary heart disease. The key to treating hypercholesterolemia is lowering plasma cholesterol levels.
Wenjing Liu, Bing Liang, Jun Zeng, Jingsen Meng, Lingyu Shi, Shanbo Yang, Jing Chang, Chao Wang, Xiaokun Hu, Xufu Wang, Na Han, Chenghui Lu, Jiao Li, Congcong Wang, Huanting Li, Renshuai Zhang, Dongming Xing   +16 more
doaj   +1 more source

Dietary cholesterol directly induces acute inflammasome-dependent intestinal inflammation [PDF]

, 2014
Prolonged ingestion of a cholesterol- or saturated fatty acid-enriched diet induces chronic, often systemic, auto-inflammatory responses resulting in significant health problems worldwide.
Bugeon, L, Cheung, J, Dallman, MJ, Lamb, JR, Marchesi, JR, McBrien, M, Progatzky, F, Sangha, NJ, Scott, J, Shia, A, Yoshida, N   +10 more
core   +3 more sources

Mathematically modelling the dynamics of cholesterol metabolism and ageing [PDF]

, 2016
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the UK. This conditionbecomes increasingly prevalent during ageing; 34.1% and 29.8% of males and females respectively, over 75years of age have an underlying cardiovascular ...
A.E. Morgan, Abbott, Ajouz, Al-Sheraji, Anandaraja, Appelman, Atzel, Atzel, Atzmon, Austin, Baigent, Baptissart, Barter, Barzilai, Batta, Begley, Berard, Bertolotti, Bertolotti, Bhattacharya, Boone, Brown, Chang, Chapman, Chirackal Manavalan, Cooney, Cooper, Cui, Demirezen, Duan, Dujovne, Ericsson, Field, Fu, Gerard, Gillotte, Guo, He, He, Hennessy, Herron, Hollander, Hoops, Hopkins, Hopkins, Hovingh, Hubner, Hucka, Hucka, Ikeda, Iqbal, Jansen, Jarocki, Jerby, Ji, Jia, Jones, Jones, Juty, K.M. Mooney, Kersten, Kervizic, Le Novère, Li, Lichtenstein, Lin, Liscum, Lu, Lund-Katz, M.T. Mc Auley, Marino, Mazein, Mc Auley, Mc Auley, Mc Auley, Mc Auley, Mc Auley, McAuley, McNamara, Micheloni, Millan, Millar, Mishra, Mooney, Mooney, Morgan, Moro-Garcia, N.A. Pickles, Ohashi, Ohtani, Olivecrona, Parini, Patsch, Petersen, Prince, Quintao, Rohn, S.J. Wilkinson, Scheibner, Sharma, Shorten, Sips, Sorci-Thomas, Spady, Tanaka, Tannock, Trautwein, Tuohy, Uchida, van de Pas, Wang, Watterson, WHO, Woollett, Yang, Zhang, Zhong   +116 more
core   +3 more sources

SREBP2 mediates the modulation of intestinal NPC1L1 expression by curcumin [PDF]

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2011
Curcumin, the major phenolic compound in the spice turmeric, exhibits numerous biological effects, including lowering plasma cholesterol and preventing diet-induced hypercholesterolemia. The mechanisms underlying the hypocholesterolemic effect of curcumin are not fully understood.
Pradeep, Kumar, Pooja, Malhotra, Ke, Ma, Amika, Singla, Omar, Hedroug, Seema, Saksena, Pradeep K, Dudeja, Ravinder K, Gill, Waddah A, Alrefai   +8 more
openaire   +2 more sources

Hepatitis C virus, cholesterol and lipoproteins--impact for the viral life cycle and pathogenesis of liver disease. [PDF]

, 2013
Hepatitis C virus (HCV) is a leading cause of chronic liver disease, including chronic hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma.
Agnello, Aizaki, Amako, Amako, Anderson, Atsukawa, Bader, Bishop, Boulant, Bradley, Bradley, Brasaemle, Bulankina, Calland, Catherine Schuster, Chhatwal, Chojkier, Ciesek, Clark, Dallinga-Thie, Daniel Felmlee, Dao Thi, Dienes, Enjoji, Esau, Forde, Fraser, Goldwasser, Grove, Haid, Harrison, Herker, Hijikata, Hirata, Hsu, Huang, Icard, Ishibashi, Jopling, Kaito, Kanto, Koutsoudakis, Lambert, Lanford, Lin, Lindenbach, Mancone, Martin, Marzouk, Mathieu Lefevre, McHutchison, Meex, Meunier, Miyanari, Mohamed Hafirassou, Nahmias, Nakamuta, Nishimura, Packard, Pecheur, Petit, Poynard, Prentoe, Pumeechockchai, Ramcharran, Reiss, Rocha-Perugini, Roe, Romero-Brey, Sakamoto, Sarasin-Filipowicz, Scholtes, Schuster, Serfaty, Sezaki, Shavinskaya, Shi, Shimakami, Stanford, Targett-Adams, Thomas Baumert, Thomssen, Tsai, Voisset, Wakita, Weng, Westin, Ye, Zeisel   +88 more
core   +7 more sources

Genetic Variation in NPC1L1 and Risk of Gallstone Disease

Journal of the American College of Cardiology, 2015
We read with great interest the recent paper by Ference et al. [(1)][1] using genetic variants in NPC1L1 (target for ezetimibe) and HMGCR (target for statins) to predict the effect of ezetimibe and statins on low-density lipoprotein (LDL) cholesterol and risk of coronary heart disease ...
Lauridsen, Bo Kobberø, Stender, Stefan, Tybjærg-Hansen, Anne   +2 more
openaire   +3 more sources

Novel polyketide from Fusarium verticillioide G102 as NPC1L1 inhibitors

Natural Product Research, 2023
One novel polyketide, fusaritide A (1), was isolated from a marine fish-derived halotolerant fungal strain Fusarium verticillioide G102. The structure was determined through extensive spectroscopic analysis and high-resolution electrospray ionization mass spectrometry.
Yuhan Zhang, Wenjing Liu, Gang Li, Changzheng Wu, Jing Yan, Dan Feng, Shuangzhi Yuan, Renshuai Zhang, Hongxiang Lou, Xiaoping Peng   +9 more
openaire   +2 more sources