Results 31 to 40 of about 4,731 (194)
Membrane topology of human NPC1L1, a key protein in enterohepatic cholesterol absorption
Journal of Lipid Research, 2009 The Niemann-Pick C1 Like 1 (NPC1L1) is a predicted polytopic membrane protein that is critical for cholesterol absorption. NPC1L1 takes up free cholesterol into cells through vesicular endocytosis.
Jiang Wang +5 more
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Genetic inactivation of NPC1L1 protects against sitosterolemia in mice lacking ABCG5/ABCG8
Journal of Lipid Research, 2009 Mice lacking Niemann-Pick C1-Like 1 (NPC1L1) (NPC1L1−/−mice) exhibit a defect in intestinal absorption of cholesterol and phytosterols. However, wild-type (WT) mice do not efficiently absorb and accumulate phytosterols either.
Weiqing Tang +5 more
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Inter-domain dynamics drive cholesterol transport by NPC1 and NPC1L1 proteins
eLife, 2020 Transport of LDL-derived cholesterol from lysosomes into the cytoplasm requires NPC1 protein; NPC1L1 mediates uptake of dietary cholesterol. We introduced single disulfide bonds into NPC1 and NPC1L1 to explore the importance of inter-domain dynamics in ...
Piyali Saha +8 more
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Intestinal and Hepatic Niemann-Pick C1-Like 1 [PDF]
Diabetes & Metabolism Journal, 2013 Polytopic transmembrane protein, Niemann-Pick C1-Like 1 (NPC1L1) is localized at the apical membrane of enterocytes and the canalicular membrane of hepatocytes.
Sung-Woo Park
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Mutations inNPC1L1and Coronary Heart Disease
New England Journal of Medicine, 2015 n engl j med 372;9 nejm.org february 26, 2015 881 between lower thresholds for glycated hemoglobin (as well as albuminuria and possibly other variables of interest) and adverse cardiovascular events were beyond the scope of our study, we agree that such investigations would be valuable and should be pursued in future studies. In response to Magliano et
Oliver, Weingärtner +2 more
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Structural insights into the mechanism of human NPC1L1-mediated cholesterol uptake [PDF]
Science Advances, 2021 Structures of NPC1L1 reveal how NPC1L1 senses the cholesterol level by conformational changes of the sterol-sensing domain.
Miaoqing Hu +6 more
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Ezetimibe blocks the internalization of NPC1L1 and cholesterol in mouse small intestine
Journal of Lipid Research, 2012 The multiple transmembrane protein Niemann-Pick C1 like1 (NPC1L1) is essential for intestinal cholesterol absorption. Ezetimibe binds to NPC1L1 and is a clinically used cholesterol absorption inhibitor.
Chang Xie 谢畅 +7 more
doaj +1 more source
Lipids in Health and Disease, 2021 Background Colorectal cancer (CRC) is a malignancy of the large intestine, whose development and prognosis have been demonstrated to be associated with altered lipid metabolism.
Ryuk Jun Kwon +6 more
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Duodenal Niemann-Pick C1-like 1 expression was negatively correlated with liver X receptor expression in nonalcoholic fatty liver disease [PDF]
The Korean Journal of Internal Medicine, 2019 Background/Aims Intestinal cholesterol absorption includes intestinal Niemann-Pick C1-like 1 (NPC1L1) and is an important target pathway in nonalcoholic fatty liver disease (NAFLD).
Sang Bong Ahn +4 more
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Journal of Biomedical Science, 2023 Background Cholesterol gallstone disease is a common disease. Reducing cholesterol burden is important to prevent/treat gallstone. In this study, we investigated the application of diosgenin (DG) to prevent the formation of gallstone in mice.
Weiyi Shen +7 more
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