Ezetimibe therapy: mechanism of action and clinical update. [PDF]
, 2012 The lowering of low-density lipoprotein cholesterol (LDL-C) is the primary target of therapy in the primary and secondary prevention of cardiovascular events.
Dayspring, Thomas D +2 more
core +1 more source
Recent advances in the screening methods of NPC1L1 inhibitors
Biomedicine & Pharmacotherapy, 2022 NPC1L1 is a crucial protein involved in sterol lipid absorption and has been shown to play an important role in intestinal cholesterol absorption. Hypercholesterolemia is a significant risk factor for cardiovascular diseases such as coronary heart disease.
Renshuai, Zhang +12 more
openaire +2 more sources
Membrane topology of human NPC1L1, a key protein in enterohepatic cholesterol absorption
Journal of Lipid Research, 2009 The Niemann-Pick C1 Like 1 (NPC1L1) is a predicted polytopic membrane protein that is critical for cholesterol absorption. NPC1L1 takes up free cholesterol into cells through vesicular endocytosis.
Jiang Wang +5 more
doaj +1 more source
NPC1L1 identified as a novel HCV entry factor [PDF]
Nature Reviews Gastroenterology & Hepatology, 2012 Katrina Ray
openalex +2 more sources
Establishing the precise evolutionary history of a gene improves prediction of disease-causing missense mutations [PDF]
, 2016 PURPOSE: Predicting the phenotypic effects of mutations has become an important application in clinical genetic diagnostics. Computational tools evaluate the behavior of the variant over evolutionary time and assume that variations seen during the course
Alexander O. Reznik +43 more
core +3 more sources
The NPC1L1 Polymorphism 1679C>G Is Associated with Gallstone Disease in Chinese Patients. [PDF]
PLoS ONE, 2016 Niemann Pick Type C1 Like 1 (NPC1L1) protein plays a key role in intestinal and hepatic cholesterol metabolism in humans. Genetic variation in NPC1L1 has been widely studied in recent years.
Jian Wu +7 more
doaj +1 more source
Atorvastatin increases intestinal expression of NPC1L1 in hyperlipidemic men [PDF]
Journal of Lipid Research, 2011 Inhibition of cholesterol synthesis by 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoAR) inhibitors has been associated with an increase in intestinal cholesterol absorption. This study examined how HMG-CoAR inhibition by atorvastatin modulates expression of key genes involved in intestinal cholesterol metabolism.
André J. Tremblay +7 more
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Intestinal and Hepatic Niemann-Pick C1-Like 1 [PDF]
Diabetes & Metabolism Journal, 2013 Polytopic transmembrane protein, Niemann-Pick C1-Like 1 (NPC1L1) is localized at the apical membrane of enterocytes and the canalicular membrane of hepatocytes.
Sung-Woo Park
doaj +1 more source
Alterations of intestinal lipoprotein metabolism in diabetes mellitus and metabolic syndrome [PDF]
, 2015 Diabetes and metabolic syndrome are associated with abnormal postprandial lipoprotein metabolism, with a significant delay in the clearance of many lipid parameters, including triglycerides and chylomicrons.
ARCA, Marcello
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Mutations inNPC1L1and Coronary Heart Disease
New England Journal of Medicine, 2015 n engl j med 372;9 nejm.org february 26, 2015 881 between lower thresholds for glycated hemoglobin (as well as albuminuria and possibly other variables of interest) and adverse cardiovascular events were beyond the scope of our study, we agree that such investigations would be valuable and should be pursued in future studies. In response to Magliano et
Silbernagel, Günther +2 more
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