Results 91 to 100 of about 7,302 (251)

Co-Expression of Niemann-Pick Type C1-Like1 (NPC1L1) with ACE2 Receptor Synergistically Enhances SARS-CoV-2 Entry and Fusion

Biomedicines
The entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into human embryonic kidney (HEK293T) cells has been shown to be a cholesterol-rich, lipid raft-dependent process.
James Elste, Nicole Cast, Shalini Udawatte, Kabita Adhikari, Shannon Harger Payen, Subhash C. Verma, Deepak Shukla, Michelle Swanson-Mungerson, Vaibhav Tiwari   +8 more
doaj   +1 more source

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles. [PDF]

, 2017
Treatment of dyslipidemia patients with lipid-lowering drugs leads to a significant reduction in low-density lipoproteins (LDL) level and a low to moderate level of increase in high-density lipoprotein (HDL) cholesterol in plasma.
Alderete, Benjamin, Amento, Edward P, Kong, Raymond, Liu, David, Lundry, Jason, Madasamy, Shanmugavel, Robinson, J Paul, Wu, Alan HB   +7 more
core   +1 more source

Lipid‐Lowering Potential of Food Formulations Based on Culinary‐Treated Flours of Dioscorea bulbifera (Dana) in Obese and Hyperlipidemic Rats

Food Safety and Health, Volume 4, Issue 1, Page 233-246, January 2026.
This graphical abstract highlights the nutritional management of obesity through food formulations based on the two varieties (white and black) of Dioscorea bulbifera yams that has undergone culinary treatments (boiling and braising). The results show that white Dioscorea bulbifera showed the best properties compared to black after the culinary ...
Fossouo Towa Patrik Florent, Maffo Tazoho Ghislain, Tekou Florian Amel, Kenfack Justine Odelonne, Zokou Ronice, Dangang Bossi Donald Séverin, Womeni Hilaire Macaire   +6 more
wiley   +1 more source

Metabolomic Profiling of Statin Use and Genetic Inhibition of HMG-CoA Reductase [PDF]

, 2015
Background Statins are first-line therapy for cardiovascular disease prevention, but their systemic effects across lipoprotein subclasses, fatty acids, and circulating metabolites remain incompletely characterized.
Ala-Korpela, M, Casas, J-P, Chaturvedi, N, Fatemifar, G, Hingorani, AD, Hughes, AD, Jarvelin, M-R, Kahonen, M, Kangas, AJ, Kettunen, J, Kivimaki, M, Lawlor, DA, Lehtimaki, T, Mantyselka, P, Perola, M, Raitakari, OT, Salomaa, V, Sattar, N, Smith, GD, Soininen, P, Tiainen, M, Tillin, T, Tynkkynen, T, Vanhala, M, Wang, Q, Wurtz, P   +25 more
core   +2 more sources

Sterol Metabolism in Ovariectomized Rats: Potential Roles of Campesterol and 4β‐Hydroxycholesterol in Osteoporosis

Lipids, Volume 61, Issue 1, Page 151-162, January 2026.
ABSTRACT Osteoporosis is characterized by low bone mass and microarchitectural deterioration of bone tissue. Lipid metabolism disorders may contribute to osteoporosis in postmenopausal women. Phytosterols and oxysterols (OC) are involved in lipid metabolism.
Wenzhao He, Sayuri Eguchi, Sen Wang, Yasutake Tanaka, Masao Sato   +4 more
wiley   +1 more source

Effects of ezetimibe on cholesterol metabolism in HIV-infected patients with protease inhibitor-associated dyslipidemia: a single-arm intervention trial [PDF]

, 2018
BACKGROUND: The effects of ezetimibe on cholesterol metabolism in HIV-infected patients receiving boosted protease inhibitors have not been thoroughly assessed.
Cofán Pujol, Montserrat, Forga, María T., Larrousse Morellón, Maria, Leyes, Pere, Martínez Chamorro, Esteban José, Pérez-Heras, Ana Maria, Ros Rahola, Emilio, Trabal, Joan   +7 more
core   +1 more source

Mendelian Randomization With Longitudinal Exposure Data: Simulation Study and Real Data Application

Statistics in Medicine, Volume 45, Issue 1-2, January 2026.
ABSTRACT Background and Aim Mendelian randomization (MR) is a widely used tool to estimate causal effects using genetic variants as instrumental variables. MR is limited to cross‐sectional summary statistics of different samples and time points to analyze time‐varying effects.
Janne Pott, Marco Palma, Yi Liu, Jasmine A. Mack, Ulla Sovio, Gordon C. S. Smith, Jessica Barrett, Stephen Burgess   +7 more
wiley   +1 more source

Niemann-Pick C1-Like 1 deletion in mice prevents high-fat diet-induced fatty liver by reducing lipogenesis[S]

Journal of Lipid Research, 2010
Niemann-Pick C1-Like 1 (NPC1L1) mediates intestinal absorption of dietary and biliary cholesterol. Ezetimibe, by inhibiting NPC1L1 function, is widely used to treat hypercholesterolemia in humans.
Lin Jia, Yinyan Ma, Shunxing Rong, Jenna L. Betters, Ping Xie, Soonkyu Chung, Nanping Wang, Weiqing Tang, Liqing Yu   +8 more
doaj   +1 more source

CREBH Regulates Systemic Glucose and Lipid Metabolism [PDF]

, 2018
The cyclic adenosine monophosphate (cAMP)-responsive element-binding protein H (CREBH, encoded by CREB3L3) is a membrane-bound transcriptional factor that primarily localizes in the liver and small intestine.
Nakagawa Yoshimi, Shimano Hitoshi, 中川 嘉   +2 more
core   +2 more sources

Pigments, Chromatophore Structure, and Gene Expression Underlying Colour Polytypy of a Panamanian Poison Frog

Molecular Ecology, Volume 35, Issue 1, January 2026.
ABSTRACT Colour polytypism represents an example of phenotypic diversification shaped by genetic divergence and ecological pressures. Poison frogs of the genus Oophaga (Dendrobatidae) are highly polytypic in coloration, making them an ideal system for investigating the genetic and physiological basis of colour variation.
Vasiliki Mantzana‐Oikonomaki, Giselle Tamayo‐Castillo, Víctor Vásquez‐Cháves, Abel Mora‐Machado, William J. Zamora Ramirez, Roberto Ibáñez, Heike Pröhl, Ariel Rodríguez   +7 more
wiley   +1 more source