Results 91 to 100 of about 4,731 (194)

Decreased NPC1L1 expression in the liver from Chinese female gallstone patients

Lipids in Health and Disease, 2010
Background Cholesterol gallstone disease is a very common disease in both industrialized and developing countries. Many studies have found that cholesterol gallstones are more common in women than men. The molecular mechanisms underlying the relationship
Zhang Sheng-Dao, Fei Jian, Wang Jian-Cheng, Wu Wei-Ze, Zhang Ru-Yuan, Cai Qu, Jiang Zhao-Yan, Cui Wei, Han Tian-Quan   +8 more
doaj   +1 more source

Fenofibrate reduces intestinal cholesterol absorption via PPARα-dependent modulation of NPC1L1 expression in mouse

Journal of Lipid Research, 2007
Fibrates, including fenofibrate, exert their biological effects by binding peroxisome proliferator-activated receptor α (PPARα), a member of the nuclear receptor superfamily of ligand-activated transcription factors.
Mark A. Valasek, Stephen L. Clarke, Joyce J. Repa   +2 more
doaj   +1 more source

NPC1L1 and SR-BI are involved in intestinal cholesterol absorption from small-size lipid donors

, 2008
International audienceIn the human intestinal content after a meal, cholesterol is dispersed in a complex mixture of emulsified droplets, vesicles, mixed micelles and precipitated material.
Annie Giraud, Haikal, Ziad, Ziad Haikal, Jean‐François Landrier, Odette Ghiringhelli, Barbara Play, Landrier, Jean-Francois, Dominique Jourdheuil‐Rahmani, Denis Lairon, Play, Barbara, Giraud, Annie, Lairon, Denis, Jourdheuil-Rahmani, Dominique, Ghiringhelli, Odette   +13 more
core   +1 more source

Sterol Binding and Specificity of NPC1L1(NTD).

, 2013
(A) Cholesterol binding. Each reaction, in a final volume of 100 µl, contained 0.5 pmol of purified HIS6-NPC1L1(NTD) and the indicated concentration of 3H-cholesterol in the absence (•) or presence (○) of 100 uM unlabeled cholesterol.
Hyock Joo Kwon (353193), Maya Palnitkar (353194), Johann Deisenhofer (54414)   +2 more
core   +1 more source

Diosgenin stimulation of fecal cholesterol excretion in mice is not NPC1L1 dependent

Journal of Lipid Research, 2009
Diosgenin exists in some food supplements and herbal medicines and lowers plasma cholesterol by increasing fecal cholesterol excretion. It is believed that diosgenin promotes fecal cholesterol excretion by stimulating biliary cholesterol secretion and ...
Ryan E. Temel, J. Mark Brown, Yinyan Ma, Weiqing Tang, Lawrence L. Rudel, Yiannis A. Ioannou, Joanna P. Davies, Liqing Yu   +7 more
doaj   +1 more source

Multiple plasma membrane receptors but not NPC1L1 mediate high-affinity, ezetimibe-sensitive cholesterol uptake into the intestinal brush border membrane.

, 2007
We compared cholesterol uptake into brush border membrane vesicles (BBMV) made from the small intestines of either wild-type or Niemann-Pick C1-like 1 (NPC1L1) knockout mice to elucidate the contribution of NPC1L1 to facilitated uptake; this uptake ...
Kvaernø L, Phillips MC, Hauser H, Carreira EM, Ioannou YA, Davies JP, Knöpfel M, Duong PT   +7 more
core   +1 more source

Regulation of intestinal NPC1L1 expression by dietary fish oil and docosahexaenoic acid

Journal of Lipid Research, 2007
To address the effect of the n-3 fatty acid, docosahexaenoic acid (22:6), on proteins that play a role in cholesterol absorption, CaCo-2 cells were incubated with taurocholate micelles alone or micelles containing 22:6 or oleic acid (18:1). Compared with
Satya N. Mathur, Kim R. Watt, F. Jeffrey Field   +2 more
doaj   +1 more source

Standardization of PCR-RFLP analysis of nsSNP rs1468384 of NPC1L1 gene

Indian Journal of Human Genetics, 2008
Niemann-Pick C1-like 1 (NPC1L1) protein, a newly identified sterol influx transporter, located at the apical membrane of the enterocyte, which may actively facilitate the uptake of cholesterol by promoting the passage of sterols across the brush border membrane of the enterocyte.
Balgir, Praveen P., Khanna, Divya, Kaur, Gurlovleen   +2 more
openaire   +3 more sources

Identification of a Novel NPC1L1 Inhibitor from Danshen and Its Role in Nonalcoholic Fatty Liver Disease

Danshen, a well-known traditional Chinese medicine (TCM), has gained increasing attention for its protective effects on nonalcoholic fatty liver disease (NAFLD). However, the molecular mechanisms underlying these effects remain to be elucidated.
Donghai Xia, Xuan Jiang, Zhimou Guo, Xianlong Ye, Shenglong Zhu, Xinmiao Liang, Xiaomin Xie, Gaowa Jin, Dongping Yu, Han Zhou   +9 more
core   +1 more source

Pravastatin Modulate Niemann-Pick C1-Like 1 and ATP-Binding Cassette G5 and G8 to Influence Intestinal Cholesterol Absorption

Journal of Pharmacy & Pharmaceutical Sciences, 2015
Purpose. Niemann-Pick C1-like 1 (NPC1L1), ATP-binding cassette (ABC)G5, and ABCG8 mediate intestinal cholesterol absorption. It is unclear whether pravastatin (PR) or ezetimibe (EZ) affect expression of these transporters.
Atsushi Kawase, Seiji Hata, Mai Takagi, Masahiro Iwaki   +3 more
doaj   +1 more source