Results 101 to 110 of about 4,731 (194)

Rescue of mislocalized NPC1L1^{L1072T/L1168I}.

, 2014
A, HEK293 cells stably expressing hNPC1L1-EGFP (WT) or hNPC1L1L1072T/L1168I-EGFP (L1072T/L1168I) were incubated in the absence or presence of 10 µM fomiroid A for 24 h, and then plasma membranes (PM) were stained with CellMask Orange. The arrows show the
Hirokazu Kawagishi (436589), Rie Watanabe (680618), Michinori Matsuo (169167), Tsuyoshi Sakurada (680617), Kohji Yamaguchi (680619), Kazumitsu Ueda (169170), Tomohiro Chiba (680616), Noriyuki Kioka (169174), Yasuhisa Kimura (642544)   +8 more
core   +1 more source

In Vivo Responsiveness to Ezetimibe Correlates with Niemann-Pick C1 Like-1 (NPC1L1) Binding Affinity: Comparison of Multiple Species NPC1L1 Orthologs

, 2020
Ezetimibe is the first in class 2-azetidinone that decreases plasma cholesterol by blocking intestinal cholesterol absorption. Ezetimibe effectively reduces plasma cholesterol in several species including human, monkey, dog, hamster, rat, and mouse, but ...
Scott W Altmann, James H Crona, Michael P Graziano, Kim A O'neill, Brian E Hawes, Xiaorui Yao, Harry R Davis Jr   +6 more
core  

Ο ρόλος της χοληστερόλης στο διμερισμό της πρωτεϊνης NPC1L1

, 2007
Η απορρόφηση χοληστερόλης από το έντερο έχει σημαντικό ρόλο στον καθορισμό των επιπέδων χοληστερόλης στην κυκλοφορία. Πρόσφατα,κυκλοφόρησε ένας νέος θεραπευτικός παράγοντας η εζετιμίδη(ezetimibe)που μειώνει την απορρόφηση χοληστερόλης και τα επίπεδα ...
Συκαράς, Αλέξανδρος
core  

Association of NPC1L1 and HMGCR gene polymorphisms with coronary artery calcification in patients with premature triple-vessel coronary disease

BMC Medical Genomics
Background Coronary artery calcification (CAC) is a highly specific marker of atherosclerosis. Niemann-Pick C1-like 1 (NPC1L1) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) are the therapeutic targets of ezetimibe and statins, respectively,
Yulong Li, Jiawen Li, Xiaofang Tang, Jingjing Xu, Ru Liu, Lin Jiang, Jian Tian, Yin Zhang, Dong Wang, Kai Sun, Bo Xu, Wei Zhao, Rutai Hui, Runlin Gao, Lei Song, Jinqing Yuan, Xueyan Zhao   +16 more
doaj   +1 more source

Flotillins play an essential role in Niemann-Pick C1-like 1-mediated cholesterol uptake

, 2010
Dietary absorption is a major way for mammals to obtain cholesterol, which is mediated by Niemann-Pick C1-like 1 (NPC1L1) via vesicular endocytosis. One fundamental question in this process is how free cholesterol is efficiently taken up through the ...
Bo-Liang Li, Yu-Xiu Qu, Hong-Hua Miao, Wei Qi, Li-Juan Wang, Liang Ge, Bao-Liang Song   +6 more
core   +1 more source

Genetic variation in the cholesterol transporter NPC1L1, ischaemic vascular disease, and gallstone disease

, 2015
AIMS: Ezetimibe reduces plasma levels of low-density lipoprotein (LDL) cholesterol by inhibiting Niemann-Pick C1-Like protein 1 (NPC1L1), the transporter responsible for cholesterol uptake from the intestine into enterocytes and from the bile into ...
Tybjærg-Hansen, Anne, Lauridsen, Bo Kobberø, Frikke-Schmidt, Ruth, Nordestgaard, Børge G, Stender, Stefan   +4 more
core   +1 more source

THE ROLE OF NIEMANN-PICK C1-LIKE 1 (NPC1L1) PROTEIN IN CHOLESTEROL TRANSPORT AND METABOLIC DISEASES

, 2010
Niemann-Pick C1-Like 1 (NPC1L1) is a polytopic transmembrane protein critical for intestinal absorption of dietary and biliary cholesterol. Ezetimibe, by inhibiting NPC1L1 function, is widely used to lower blood cholesterol in humans.
Jia, Lin
core  

NPC1L1 wt Allele [PDF]

, 2020
openaire   +1 more source

Predictive value of serum sCD14-ST，NPC1L1，and RRM2B levels for postoperative metastasis in patients with colon cancer

Zhongguo linchuang yanjiu
Objective To explore the correlation of serum levels of soluble leukocyte differentiation antigen 14 subtype（sCD14-ST），Niemann-Pick type C1-like 1（NPC1L1），and ribonucleotide reductase regulatory subunit M2B（RRM2B）with clinicopathological features in ...
SHEN Lujun*，ZONG Liang，LI Xi，MENG Juanjuan，CAO Xia，ZHU Xiaoting，SHI Fangfang，YAN Caiwen
doaj   +1 more source

NPC1L1 as a Pharmacological Target of Hypercholesterolemia

MEMBRANE, 2008
Tappei Takada, Hiroshi Suzuki
openaire   +2 more sources