Journal of Lipid Research, 2007 Niemann-Pick C1-like 1 protein (NPC1L1) is the putative intestinal sterol transporter and the molecular target of ezetimibe, a potent inhibitor of cholesterol absorption.
F. Jeffrey Field +2 more
doaj +1 more source
A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease [PDF]
, 2015 Existing knowledge of genetic variants affecting risk of coronary artery disease (CAD) is largely based on genome-wide association studies (GWAS) analysis of common SNPs.
Alver, Maris +153 more
core +5 more sources
Female Serum HER2 Expression: Its Association With Metabolic Syndrome and Treatment Drug Response
International Journal of Endocrinology, Volume 2026, Issue 1, 2026.Objective To investigate the association between serum human epidermal growth factor receptor 2 (HER2) levels and metabolic syndrome (MS) in women and to explore the relationship between HER2 and the use of commonly prescribed metabolic medications. Methods A total of 532 women who visited Nanjing Drum Tower Hospital between January 2021 and January ...
Ruiwen Hu +8 more
wiley +1 more source
Effects of currently prescribed LDL-C-lowering drugs on PCSK9 and implications for the next generation of LDL-C-lowering agents [PDF]
, 2011 Background During the past decade, proprotein convertase subtilisin kexin type 9 (PCSK9) has been identified as a key regulator of serum LDL-cholesterol (LDL-C) levels.
Robert J Konrad +2 more
core +2 more sources
Journal of Food Biochemistry, Volume 2026, Issue 1, 2026.Hyperlipidemia is recognized as a major contributor to chronic noncommunicable diseases. The primary strategy regarding hyperlipidemia prevention is involved in the blockade of intestinal cholesterol absorption. Ezetimibe (Eze) is the sole prescribed drug that targets Niemann‐Pick C1 Like 1 (NPC1L1), a key cholesterol transporter, resulting in reduced ...
Jakkapong Inchai +8 more
wiley +1 more source
Assessing the effect of statins in lowering the risk of stroke and preventing cerebral ischemia in patients with hypercholesterolemia [PDF]
, 2017 Numerous analyses have explored the role of statins in reducing stroke incidence, reducing cerebral ischemia in hypercholesterolemic patients, and preventing ischemic stroke.
AlSulaiman, Wafa
core
Understanding the gastrointestinal tract of the elderly to develop dietary solutions that prevent malnutrition [PDF]
, 2015 Although the prevalence of malnutrition in the old age is increasing worldwide a synthetic understanding of the impact of aging on the intake, digestion, and absorption of nutrients is still lacking.
Bordoni, Alessandra +11 more
core +4 more sources
Journal of Food Processing and Preservation, Volume 2026, Issue 1, 2026.This study evaluated the effects of African locust bean pulp (ALBP) supplementation on carotenoid profile and beta‐carotene bioavailability in rats fed with instant kunu beverage. Based on preliminary studies, a freeze‐dried kunu beverage was developed with the substitution of 5%–25% ALBP for millet.
Kazeem K. Olatoye +5 more
wiley +1 more source
Modulation of lipid metabolism with the overexpression of NPC1L1 in mouse liver
Journal of Lipid Research, 2012 Niemann-Pick C1-like 1 protein (NPC1L1), a transporter crucial in intestinal cholesterol absorption, is expressed in human liver but not in murine liver. To elucidate the role of hepatic NPC1L1 on lipid metabolism, we overexpressed NPC1L1 in murine liver
Makoto Kurano +7 more
doaj +1 more source
Structures of dimeric human NPC1L1 provide insight into mechanisms for cholesterol absorption [PDF]
, 2021 Tao Long +4 more
openalex +1 more source