Results 121 to 130 of about 7,302 (251)

The NPC1L1 Gene Exerts a Notable Impact on the Reduction of Low-Density Lipoprotein Cholesterol in Response to Hyzetimibe: A Factorial-Designed Clinical Trial [PDF]

, 2022
Jianwei Liao, Liyun Yang, Luping Zhou, Hongbin Zhao, Xiao Qi, Yimin Cui, Dongsheng Ouyang   +6 more
openalex   +1 more source

Hepatitis C virus infection and related liver disease: the quest for the best animal model [PDF]

, 2013
Hepatitis C virus (HCV) is a major cause of cirrhosis and hepatocellular carcinoma (HCC) making the virus the most common cause of liver failure and transplantation.
Baumert, Thomas F, Mailly, Laurent, Meuleman, Philip, Robinet, Eric, Zeisel, Mirjam   +4 more
core   +3 more sources

Novel application potential of cinaciguat in the treatment of mixed hyperlipidemia through targeting PTL/NPC1L1 and alleviating intestinal microbiota dysbiosis and metabolic disorders

, 2023
Ang Jia, Hongfei Jiang, Wenjing Liu, Pengwei Chen, Qi Xu, Renshuai Zhang, Ju‐Feng Sun   +6 more
openalex   +1 more source

Interaction of cholesterol with sphingosine

Journal of Lipid Research, 2005
Molecular associations between sphingomyelin and cholesterol provide a molecular basis for the colocalization of these lipids in plasma membrane microdomains (lipid rafts) and for the inhibitory effect of sphingomyelin on the intestinal absorption of ...
Nicolas Garmy, Nadira Taïeb, Nouara Yahi, Jacques Fantini   +3 more
doaj   +1 more source

Distinct Binding Modes Dictate the Epimerization-Related Selectivity in the Binding of Cholesterol to the N-terminal Domain of the NPC1L1 Transporter

, 2023
Aitor Valdivia, F. Javier Luque, Salomé Llabrés   +2 more
openalex   +2 more sources

“EFECTOS DE UNA DIETA ELEVADA EN HIDRATOS DE CARBONO Y LÍPIDOS, SOBRE EL SISTEMA INMUNITARIO DEL INTESTINO DELGADO EN RATONES Balb/c, ENERO 2013” [PDF]

, 2013
En el intestino delgado se llevan a cabo las funciones más importantes de digestión y absorción de los nutrimentos, también sirve como defensa de agentes invasores a través del sistema inmunitario de las mucosas que proporciona defensa al individuo en ...
Alpizar Vergara, Mayra Socorro, Martínez Carillo, Beatriz Elina, Ruíz Weber, Andrea Stephanie   +2 more
core  

Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels [PDF]

, 2016
Background So far, more than 170 loci have been associated with circulating lipid levels through genomewide association studies (GWAS). These associations are largely driven by common variants, their function is often not known, and many are likely to be
Arking, D.E. (Dan E.), Bis, J.C. (Joshua), Boerwinkle, E. (Eric), Boomsma, D.I. (Dorret), Borecki, I.B. (Ingrid), Brody, J.A. (Jennifer A.), Campbell, A. (Archie), Campbell, H. (Harry), Chambers, J.C. (John C.), Cooper, R.S. (Richard S.), Craen, A.J. (Anton) de, Cupples, L.A. (Adrienne), de Ruijter, H.M. (Hester M.), Deelen, J. (Joris), Dehghan, A. (Abbas), Demissie, S. (Serkalem), Duan, Q. (Qing), Duijn, C.M. (Cornelia) van, Elliott, P. (Paul), Evangelou, E. (Evangelos), Feitosa, M.F. (Mary Furlan), Ford, I. (Ian), Forrester, T. (Terrence), Franco, O.H. (Oscar), Gansevoort, R.T. (Ron), Geus, E.J.C. (Eco) de, Gudnason, V. (Vilmundur), Harris, T.B. (Tamara), Harst, P. (Pim) van der, Hayward, C. (Caroline), Hocking, L.J. (Lynne), Hofman, A. (Albert), Huffman, J.E. (Jennifer), Isaacs, A.J. (Aaron), Joshi, P.K. (Peter), Jukema, J.W. (Jan Wouter), Klinken, J.B. (Jan Bert) van, Kolcic, I. (Ivana), Kooner, J.S. (Jaspal S.), Kooner, J.S. (Jaspal), Kähönen, M. (Mika), Lange, L.A. (Leslie), Leeuwen, E.M. (Elisa) van, Lehne, B. (Benjamin), Lehtimäki, T. (Terho), Li-Gao, R. (Ruifang), Lyytikäinen, L.-P. (Leo-Pekka), Manichaikul, A. (Ani), Marten, J. (Jonathan), Mbarek, H., McKenzie, C.A. (Colin), Milaneschi, Y. (Yuri), Mook-Kanamori, D.O. (Dennis), Morrison, A. (Alanna), Most, P.J. (Peter) van der, Mutsert, R. (Reneé) de, Mychaleckyj, J.C. (Josyf), Navarro, P. (Pau), Nikus, K. (Kjell), Nolte, I.M. (Ilja), Oldehinkel, A.J. (Albertine), Padmanabhan, S. (Sandosh), Pasterkamp, G. (Gerard), Penninx, B.W.J.H. (Brenda), Polasek, O. (Ozren), Psaty, B.M. (Bruce), Raitakari, O.T. (Olli T.), Rice, K.M. (Kenneth), Rich, S.S. (Stephen), Ripatti, S. (Samuli), Rivadeneira Ramirez, F. (Fernando), Rotter, J.I. (Jerome I.), Rudan, I. (Igor), Sabo, A. (Aniko), Salomaa, V. (Veikko), Scott, W.R. (William R.), Segura-Lepe, M.P. (Marcelo P.), Sijbrands, E.J.G. (Eric), Slagboom, P.E. (Eline), Smith, A.V. (Davey), Snieder, H. (Harold), Surakka, I. (Ida), Swertz, M. (Morris), Tan, S.-T. (Sian-Tsung), Tayo, B. (Bamidele), Trompet, S. (Stella), Uitterlinden, A.G. (André), Van Der Laan, S.W. (Sander W.), Verweij, N. (Niek), Viikari, J. (Jorma), Vitart, V. (Veronique), White, C.C. (Charles), Willems van Dijk, J.A.P. (Ko), Willemsen, G.A.H.M. (Gonneke), Wilson, J.F. (James F), Wilson, J.G. (James G.), Zemunik, T. (Tatijana), Zhang, W. (Weihua)   +97 more
core   +1 more source

Genetic variation at the NPC1L1 gene locus, plasma lipoproteins, and heart disease risk in the elderly[S]

Journal of Lipid Research, 2010
Niemann-Pick C1-like 1 protein (NPC1L1) plays a critical role in intestinal cholesterol absorption. Our objective was to examine whether five variants (-133A>G, -18A>C, L272L, V1296V, and U3_28650A>G) at the NPC1L1 gene have effects on lipid levels ...
Eliana Polisecki, Inga Peter, Jason S. Simon, Robert A. Hegele, Michele Robertson, Ian Ford, James Shepherd, Christopher Packard, J. Wouter Jukema, Anton J.M. de Craen, Rudi G.J. Westendorp, Brendan M. Buckley, Ernst J. Schaefer   +12 more
doaj   +1 more source

Pathophysiological importance of bile cholesterol reabsorption: hepatic NPC1L1-exacerbated steatosis and decreasing VLDL-TG secretion in mice fed a high-fat diet

Lipids in Health and Disease, 2019
Background Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases worldwide, although its pathogenesis remains to be elucidated.
Yu Toyoda, Tappei Takada, Yoshihide Yamanashi, Hiroshi Suzuki   +3 more
doaj   +1 more source

Polymorphisms in the WNK1 gene are asociated with blood pressure variation and urinary potassium excretion [PDF]

, 2009
WNK1 - a serine/threonine kinase involved in electrolyte homeostasis and blood pressure (BP) control - is an excellent candidate gene for essential hypertension (EH). We and others have previously reported association between WNK1 and BP variation. Using
Brown, M, Brunner, E, Burke, B, Cappucio, FP, Caulfield, M, Chambers, J, Clarke, R, Collins, R, Connell, JM, Dobson, R, Dominiczak, AF, Elliott, P, Eyheramendy, S, Farrall, M, Hoti, M, Howard, P, Iacone, R, Ji, C, Juhanson, P, Kooner, J, Kumari, M, Laan, M, Lathrop, GM, Lee, K, Marmot, M, Munroe, PB, Newhouse, S, Onipinla, A, Org, E, Samani, NJ, Shaw-Hawkins, S, Strazzullo, P, Veldre, G, Viigimaa, M, Wallace, C   +34 more
core