Results 61 to 70 of about 115,838,581 (186)

Cyanidin-3-rutinoside acts as a natural inhibitor of intestinal lipid digestion and absorption

BMC Complementary and Alternative Medicine, 2019
Background Cyanidin-3-rutinoside (C3R), a naturally occurring anthocyanin, possesses anti-oxidant, anti-hyperglycemic, anti-glycation and cardioprotective properties.
Thavaree Thilavech, Sirichai Adisakwattana   +1 more
doaj   +1 more source

Genotype–Phenotype Correlations of Monoallelic PFIC Variants in Pediatric Liver Disease: A Multicenter Retrospective Cohort Study

American Journal of Medical Genetics Part A, Volume 200, Issue 12, Page 2692-2707, December 2026.
ABSTRACT Progressive familial intrahepatic cholestasis (PFIC) is classically caused by biallelic pathogenic variants, yet monoallelic variants of uncertain significance (VUS) in PFIC‐associated genes are increasingly identified in children with cholestasis, creating diagnostic uncertainty.
Brett J. Hoskins, Tiziano Pramparo, Chaowapong Jarasvaraparn, Michael J. Wilsey, Voytek Slowik, Lakshmi Kunam, Janis M. Stoll, Ruben E. Quiros‐Tejeira, Simon Lam, Wikrom Karnsakul   +9 more
wiley   +1 more source

Dietary cholesterol reverses resistance to diet-induced weight gain in mice lacking Niemann-Pick C1-Like 1[S]

Journal of Lipid Research, 2010
Niemann-Pick C1-Like 1 (NPC1L1) mediates intestinal cholesterol absorption. NPC1L1 knockout (L1-KO) mice were recently shown to be resistant to high-fat diet (HFD)-induced obesity in one study, which was contrary to several other studies.
Lin Jia, Yinyan Ma, George Liu, Liqing Yu   +3 more
doaj   +1 more source

Bile acids-mediated intracellular cholesterol transport promotes intestinal cholesterol absorption and NPC1L1 recycling

Nature Communications, 2023
Niemann-Pick C1-like 1 (NPC1L1) is essential for intestinal cholesterol absorption. Together with the cholesterol-rich and Flotillin-positive membrane microdomain, NPC1L1 is internalized via clathrin-mediated endocytosis and transported to endocytic ...
Jian Xiao, Le-Wei Dong, Shuai Liu, Fan-Hua Meng, Chang Xie, Xiao-Yi Lu, Weiping J. Zhang, Jie Luo, Bao-Liang Song   +8 more
doaj   +1 more source

Dyslipidaemia, Chronic Kidney Disease and Diabetes Mellitus: A Triple Threat to Cardiovascular Health

Diabetes, Obesity and Metabolism, Volume 28, Issue 12, Page 10961-10976, December 2026.
ABSTRACT Diabetes mellitus (DM) and chronic kidney disease (CKD) frequently coexist and together create a ‘triple threat’ with dyslipidaemia, enhancing the risk for cardiovascular morbidity and mortality. Diabetic kidney disease (DKD) leads to altered lipid metabolism through insulin resistance, inflammation and oxidative stress resulting in an ...
Ann S. Forrest, Priyanka Majety, Stéphanie B. Mayer, Om P. Ganda   +3 more
wiley   +1 more source

Efficacy and Safety of Oral Non‐Statin Lipid‐Lowering Therapies in Dyslipidaemia: A Systematic Review and Network Meta‐Analysis

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 6, November 2026.
A network meta‐analysis of 43 randomized trials showed that oral combination therapies, particularly obicetrapib plus ezetimibe and bempedoic acid plus ezetimibe, achieved the greatest LDL‐C reduction with reassuring safety profiles, supporting their use as effective oral alternatives for patients with dyslipidaemia. ABSTRACT Introduction Dyslipidaemia
Tamer Hodrob, Reem J. Saad, Aya Hamdy, Mariam Saleh Alheneedy, Ahmed Mohamed Shehata Abdelfattah Elsayed, Elsaghir Ghazy, Hazem Ayesh   +6 more
wiley   +1 more source

Deciphering Host Genomic Pathway Landscapes in Severe COVID‐19 by Exome Sequencing of a Large Admixed Brazilian Cohort

Journal of Medical Virology, Volume 98, Issue 11, November 2026.
ABSTRACT The host genetic factors that resulted in the heterogeneous clinical outcomes of COVID‐19 remained poorly understood, especially in admixed populations that are underrepresented in global genomic studies. In this study, we investigated the genetic landscape associated with COVID‐19 severity using whole‐exome sequencing data from 325 Brazilian ...
Aléxia Stefani Siqueira Zetum, Danielle Ribeiro Campos da Silva, Vinícius do Prado Ventorim, Felipe Ataides Mion, Felipe dos Santos Passarela, Patrícia Brasil, Túlio de Lima Campos, Bartolomeu Acioli‐Santos, Flávio Rosendo da Silva Oliveira, Raquel Silva dos Reis Trabach, Lorena Souza Castro Altoé, Débora Dummer Meira, Iúri Drumond Louro   +12 more
wiley   +1 more source

Niemann-Pick C1-Like 1 deletion in mice prevents high-fat diet-induced fatty liver by reducing lipogenesis[S]

Journal of Lipid Research, 2010
Niemann-Pick C1-Like 1 (NPC1L1) mediates intestinal absorption of dietary and biliary cholesterol. Ezetimibe, by inhibiting NPC1L1 function, is widely used to treat hypercholesterolemia in humans.
Lin Jia, Yinyan Ma, Shunxing Rong, Jenna L. Betters, Ping Xie, Soonkyu Chung, Nanping Wang, Weiqing Tang, Liqing Yu   +8 more
doaj   +1 more source

Genetic Diversity and Structure Analysis of Wild Oysters (Crassostrea virginica) Within and Between River Systems Reveals Spatial Genetic Structure and Salinity‐Adaptive Variation Across the Canadian Maritimes

Evolutionary Applications, Volume 19, Issue 10, October 2026.
ABSTRACT In the Canadian Maritimes, the eastern oyster (Crassostrea virginica) industry has been shaped by population‐scale events, including ~90% reductions of natural beds from Malpeque disease. For many years, Maritime oyster populations were considered genetically homogenous due to large‐scale transplants to rehabilitate depleted beds; however ...
Stephanie Hall, Denise Méthé, Royce Steeves, Mark LaFlamme, Curtis Dinn, Rémi Sonier, Jeff C. Clements   +6 more
wiley   +1 more source

Cholesterol Oxidation Products Are Sensitive and Specific Blood-Based Biomarkers for Niemann-Pick C1 Disease

, 2010
Oxysterols are biomarkers for diagnosis and drug treatment in Niemann-Pick C1 disease.
Dana Olzeski, Michael H. Lanier, S. Joshua Langmade, Jean E. Schaffer, David E. Scherrer, Steven P. Marso, Sarah E. Gale, Dennis J. Dietzen, Rohini Sidhu, Charles Vite, Daniel S. Ory, Christopher A. Wassif, Forbes D. Porter, Vasumathi Molugu, Rao Fu, Nicole M. Yanjanin, John House   +16 more
core   +1 more source