Erratum: Figure Correction. Intestinal and Hepatic Niemann-Pick C1-Like 1 [PDF]
Diabetes & Metabolism Journal, 2013 Diabetes Metab J 2013;37:240-248. http://dx.doi.org/10.4093/dmj.2013.37.4.240 To the Editor: An error was found in the following published article: Park SW. Intestinal and hepatic niemann-pick c1-like 1. Diabetes Metab J 2013;37(4):240-8. doi: 10.4093/dmj.2013.37.4.240 The published Fig. 1 is to explain the expression and role of NPC1L1 in the
Sung-Woo Park
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The Effect of Polyphenols on Hypercholesterolemia through Inhibiting the Transport and Expression of Niemann-Pick C1-Like 1. [PDF]
Int J Mol Sci, 2019 The Niemann–Pick C1-like 1 (NPC1L1) protein is a cholesterol transporter that is expressed in the small intestine. This report describes the discovery of NPC1L1, its transport properties, and the inhibitory effects of polyphenols on NPC1L1. NPC1L1 was identified in 2004 while searching for ezetimibe molecular targets. Excessive synthesis of cholesterol
Kobayashi S.
europepmc +5 more sources
Niemann-Pick C1-Like 1 (NPC1L1) Inhibition and Cardiovascular Diseases [PDF]
Current Medicinal Chemistry, 2016 Circulating levels of cholesterol are derived from either endogenous production or intestinal absorption of dietary and biliary cholesterol. Niemann-Pick C1-Like 1 (NPC1L1) is a transmembrane protein that plays a key role in the intestinal absorption of cholesterol by facilitating its uptake through vesicular endocytosis. NPC1L1 is the molecular target
PIRILLO, ANGELINA ANNA +2 more
core +7 more sources
Niemann-pick C1-like 1 (NPC1L1) protein in intestinal and hepatic cholesterol transport. [PDF]
Annu Rev Physiol, 2011 Increased blood cholesterol is an independent risk factor for atherosclerotic cardiovascular disease. Cholesterol homeostasis in the body is controlled mainly by endogenous synthesis, intestinal absorption, and hepatic excretion. Niemann-Pick C1-Like 1 (NPC1L1) is a polytopic transmembrane protein localized at the apical membrane of enterocytes and the
Jia L, Betters JL, Yu L.
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Transport via Niemann-Pick C1 Like 1 contributes to the intestinal absorption of ubiquinone [PDF]
Drug Metabolism and Pharmacokinetics, 2020 Ubiquinone, which is a component in the electron-transport systems of mitochondria, is essential for various activities related to energy metabolism, but the detailed absorption mechanism of ubiquinone is not clear. On the other hand, Niemann-Pick C1 Like 1 (NPC1L1) is involved in the intestinal absorption of fat-soluble components such as cholesterol.
Nashimoto, Shunsuke +4 more
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Flotillins play an essential role in Niemann-Pick C1-like 1-mediated cholesterol uptake [PDF]
Proceedings of the National Academy of Sciences, 2010 Dietary absorption is a major way for mammals to obtain cholesterol, which is mediated by Niemann-Pick C1-like 1 (NPC1L1) via vesicular endocytosis. One fundamental question in this process is how free cholesterol is efficiently taken up through the internalization of NPC1L1. Using exogenously expressed NPC1L1-EGFP, we show that the lipid raft proteins
Liang, Ge +6 more
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Journal of Pharmacy & Pharmaceutical Sciences, 2012 PURPOSE. Lutein is a carotenoid mainly found in green leafy vegetables and is located in the macula lutea in the human eye. Since humans cannot synthesize lutein de novo, it must be digested as food. The physiological importance of an orally administered
Yuki Sato +8 more
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Luteolin and quercetin affect the cholesterol absorption mediated by epithelial cholesterol transporter niemann-pick c1-like 1 in caco-2 cells and rats. [PDF]
PLoS ONE, 2014 Niemann-Pick C1-Like 1 (NPC1L1) mediates cholesterol absorption, and ezetimibe is a potent NPC1L1 inhibitor applicable for medication of hypercholesterolemia.
Mari Nekohashi +7 more
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Aspectes moleculars de dues malalties de transport lisosòmic: la cistinosi i la malaltia de Niemann-Pick tipus C [PDF]
, 2012 [cat] La cistinosi i la malaltia de Niemann-Pick tipus C (NPC) són dues patologies hereditàries monogèniques poc freqüents, per aquest motiu estan classificades dins del grup de malalties anomenades rares.
Macías Vidal, Judit
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Computational Modeling Explains the Multi Sterol Ligand Specificity of the N‑Terminal Domain of Niemann–Pick C1-Like 1 Protein [PDF]
ACS Omega, 2019 Vasanthanathan Poongavanam +2 more
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