Results 1 to 10 of about 2,022 (165)

Association of ATP binding cassette transporter G8 rs4148217 SNP and serum lipid levels in Mulao and Han nationalities [PDF]

Lipids in Health and Disease, 2012
Background The association of ATP binding cassette transporter G8 gene (ABCG8) rs4148217 single nucleotide polymorphism (SNP) and serum lipid profiles is still controversial in diverse racial/ethnic groups.
Li Qing, Wei Xian-Liang, Yin Rui-Xing
doaj   +5 more sources

ATP-binding cassette transporter G5 and G8 polymorphisms and several environmental factors with serum lipid levels. [PDF]

PLoS ONE, 2012
BackgroundThe association of ATP-binding cassette (ABC) transporter single nucleotide polymorphisms (SNPs) and serum lipid profiles is inconsistent. The present study was undertaken to detect the association of ABCG5/G8 SNPs and several environmental ...
Qing Li, Rui-Xing Yin, Xian-Liang Wei, Ting-Ting Yan, Lynn Htet Htet Aung, Dong-Feng Wu, Jin-Zhen Wu, Wei-Xiong Lin, Cheng-Wu Liu, Shang-Ling Pan   +9 more
doaj   +6 more sources

ATP binding cassette transporter G5 and G8 genotypes and plasma lipoprotein levels before and after treatment with atorvastatin [PDF]

Journal of Lipid Research, 2004
The mechanisms responsible for interindividual variation in response to statin therapy remain uncertain. It has been shown that hepatic cholesterol synthesis is associated with ATP binding cassette transporter G5 and G8 (ABCG5/8) activities.
Kouji Kajinami, Margaret E. Brousseau, Chorthip Nartsupha, Jose M. Ordovas, Ernst J. Schaefer   +4 more
doaj   +3 more sources

Cholesterol feeding strongly reduces hepatic VLDL-triglyceride production in mice lacking the liver X receptor αs⃞ [PDF]

Journal of Lipid Research, 2007
The oxysterol-activated nuclear receptor liver X receptor α (LXRα) has been implicated in the control of both cholesterol and fatty acid metabolism.
Jelske N. van der Veen, Rick Havinga, Vincent W. Bloks, Albert K. Groen, Folkert Kuipers   +4 more
doaj   +4 more sources

Thematic Review Series: Lipid Transfer Proteins ABCG5 and ABCG8: more than a defense against xenosterols [PDF]

Journal of Lipid Research, 2018
The elucidation of the molecular basis of the rare disease, sitosterolemia, has revolutionized our mechanistic understanding of how dietary sterols are excreted and how cholesterol is eliminated from the body.
Shailendra B. Patel, Gregory A. Graf, Ryan E. Temel   +2 more
doaj   +3 more sources

Excessive exogenous cholesterol activating intestinal LXRα-ABCA1/G5/G8 signaling pathway can not reverse atherosclerosis in ApoE−/− mice [PDF]

Lipids in Health and Disease, 2023
Background The long-term excessive intake of exogenous cholesterol can lead to abnormally elevated blood lipid levels and induce cardiovascular and cerebrovascular diseases.
Xichao Yu, Xue Ding, Han Feng, Yunhui Bi, Yu Li, Jinjun Shan, Huimin Bian   +6 more
doaj   +2 more sources

ATP-Binding Cassette Transporter G8 Gene As a Determinant of Apolipoprotein B-100 Kinetics in Overweight Men [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2004
Objective— We examined the influence of genetic variation of the ATP-binding cassette (ABC) transporter G8 on apolipoprotein B (apoB) kinetics in overweight/obese men. Methods and Results— Very low–density lipoprotein (VLDL ...
D C, Chan, G F, Watts, P H R, Barrett, A J, Whitfield, F M, van Bockxmeer   +4 more
openaire   +2 more sources

The Effects of Polyphenol-Rich Black Elderberry on Oxidative Stress and Hepatic Cholesterol Metabolism

Applied Sciences, 2021
Black elderberry (Sambucus Nigar) with high polyphenol content has been reported to have a hypolipidemic effect, but its underlying mechanisms have not been well characterized.
Sohyeon Jeon, Sanggil Lee, Yeoni Choi, Bohkyung Kim   +3 more
doaj   +1 more source

Stimulation of Cholesterol Excretion by the Liver X Receptor Agonist Requires ATP-binding Cassette Transporters G5 and G8 [PDF]

Journal of Biological Chemistry, 2003
Liver X receptor (LXR) is a nuclear receptor that plays a crucial role in orchestrating the trafficking of sterols between tissues. Treatment of mice with a potent and specific LXR agonist, T0901317, is associated with increased biliary cholesterol secretion, decreased fractional cholesterol absorption, and increased fecal neutral sterol excretion ...
Liqing, Yu, Jennifer, York, Klaus, von Bergmann, Dieter, Lutjohann, Jonathan C, Cohen, Helen H, Hobbs   +5 more
openaire   +2 more sources

Polyphenol-Rich Black Elderberry Extract Stimulates Transintestinal Cholesterol Excretion

Applied Sciences, 2021
Hypercholesterolemia is the primary risk factor for cardiovascular disease (CVD). Recent studies reported that the stimulation of transintestinal cholesterol excretion (TICE), a nonbiliary cholesterol excretion, can be a strategy for preventing CVD ...
Sohyeon Jeon, Minji Kim, Bohkyung Kim
doaj   +1 more source