Results 1 to 10 of about 1,805,873 (166)

Association of ATP binding cassette transporter G8 rs4148217 SNP and serum lipid levels in Mulao and Han nationalities [PDF]

Lipids in Health and Disease, 2012
Background The association of ATP binding cassette transporter G8 gene (ABCG8) rs4148217 single nucleotide polymorphism (SNP) and serum lipid profiles is still controversial in diverse racial/ethnic groups.
Li Qing, Wei Xian-Liang, Yin Rui-Xing
doaj   +6 more sources

ATP-binding cassette transporter G5 and G8 polymorphisms and several environmental factors with serum lipid levels.

PLoS ONE, 2012
BackgroundThe association of ATP-binding cassette (ABC) transporter single nucleotide polymorphisms (SNPs) and serum lipid profiles is inconsistent. The present study was undertaken to detect the association of ABCG5/G8 SNPs and several environmental ...
Qing Li, Rui-Xing Yin, Xian-Liang Wei, Ting-Ting Yan, Lynn Htet Htet Aung, Dong-Feng Wu, Jin-Zhen Wu, Wei-Xiong Lin, Cheng-Wu Liu, Shang-Ling Pan   +9 more
doaj   +4 more sources

ATP binding cassette transporter G5 and G8 genotypes and plasma lipoprotein levels before and after treatment with atorvastatin [PDF]

Journal of Lipid Research, 2004
The mechanisms responsible for interindividual variation in response to statin therapy remain uncertain. It has been shown that hepatic cholesterol synthesis is associated with ATP binding cassette transporter G5 and G8 (ABCG5/8) activities.
Kouji Kajinami, Margaret E. Brousseau, Chorthip Nartsupha, Jose M. Ordovas, Ernst J. Schaefer   +4 more
doaj   +3 more sources

Metformin and AMP Kinase Activation Increase Expression of the Sterol Transporters ABCG5/8 (ATP-Binding Cassette Transporter G5/G8) With Potential Antiatherogenic Consequences [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2018
Objective— The mechanisms underlying the cardiovascular benefit of the anti-diabetic drug metformin are poorly understood. Recent studies have suggested metformin may upregulate macrophage reverse cholesterol transport.
Molusky, Matthew M., Hsieh, Joanne, Lee, Samuel X., Ramakrishnan, Rajasekhar, Tascau, Liana, Haeusler, Rebecca A., Accili, Domenico, Tall, Alan R.   +7 more
openaire   +3 more sources

ATP-Binding Cassette Transporter G8 Gene As a Determinant of Apolipoprotein B-100 Kinetics in Overweight Men [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2004
Objective— We examined the influence of genetic variation of the ATP-binding cassette (ABC) transporter G8 on apolipoprotein B (apoB) kinetics in overweight/obese men. Methods and Results— Very low–density lipoprotein (VLDL ...
D C, Chan, G F, Watts, P H R, Barrett, A J, Whitfield, F M, van Bockxmeer   +4 more
openaire   +2 more sources

Stimulation of Cholesterol Excretion by the Liver X Receptor Agonist Requires ATP-binding Cassette Transporters G5 and G8 [PDF]

Journal of Biological Chemistry, 2003
Liver X receptor (LXR) is a nuclear receptor that plays a crucial role in orchestrating the trafficking of sterols between tissues. Treatment of mice with a potent and specific LXR agonist, T0901317, is associated with increased biliary cholesterol secretion, decreased fractional cholesterol absorption, and increased fecal neutral sterol excretion ...
Liqing, Yu, Jennifer, York, Klaus, von Bergmann, Dieter, Lutjohann, Jonathan C, Cohen, Helen H, Hobbs   +5 more
openaire   +2 more sources

The Effects of Polyphenol-Rich Black Elderberry on Oxidative Stress and Hepatic Cholesterol Metabolism

Applied Sciences, 2021
Black elderberry (Sambucus Nigar) with high polyphenol content has been reported to have a hypolipidemic effect, but its underlying mechanisms have not been well characterized.
Sohyeon Jeon, Sanggil Lee, Yeoni Choi, Bohkyung Kim   +3 more
doaj   +1 more source

Polyphenol-Rich Black Elderberry Extract Stimulates Transintestinal Cholesterol Excretion

Applied Sciences, 2021
Hypercholesterolemia is the primary risk factor for cardiovascular disease (CVD). Recent studies reported that the stimulation of transintestinal cholesterol excretion (TICE), a nonbiliary cholesterol excretion, can be a strategy for preventing CVD ...
Sohyeon Jeon, Minji Kim, Bohkyung Kim
doaj   +1 more source

ATP-binding cassette transporter G8 M429V polymorphism as a novel genetic marker of higher cholesterol absorption in hypercholesterolaemic Japanese subjects [PDF]

Clinical Science, 2005
The ratio of serum plant sterols to cholesterol is positively correlated with the fractional cholesterol absorption, whereas serum precursors of cholesterol synthesis are positively correlated with cholesterol synthesis. Recently, two ABC (ATP-binding cassette) transporters, ABCG5 and ABCG8, have been described as playing an important role in the ...
Kenji, Miwa, Akihiro, Inazu, Junji, Kobayashi, Toshinori, Higashikata, Atsushi, Nohara, Masaaki, Kawashiri, Shoji, Katsuda, Mutsuko, Takata, Junji, Koizumi, Hiroshi, Mabuchi   +9 more
openaire   +2 more sources

Opposing Gatekeepers of Apical Sterol Transport: Niemann-Pick C1-Like 1 (NPC1L1) and ATP-Binding Cassette Transporters G5 and G8 (ABCG5/ABCG8) [PDF]

Immunology‚ Endocrine & Metabolic Agents in Medicinal Chemistry, 2009
Cholesterol is essential for the growth and function of all mammalian cells, but abnormally elevated levels of circulating low-density lipoprotein cholesterol (LDL-C) are a major risk factor for the development of atherosclerotic cardiovascular disease (ASCVD).
J Mark, Brown, Liqing, Yu
openaire   +2 more sources