Cardiovascular TherapeuticsCardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide, and hyperlipidemia is one major inducing factor of CVD. It is worthy to note that fucoidans are reported to have hypolipidemic activity with species specificity ...
Yan Zhang +5 more
doaj +2 more sources
Age-Independent Hypocholesterolemic Effects of Rice Protein via FXR-Mediated Stimulation of Cholesterol Elimination. [PDF]
Food Sci NutrThis study examined the impact of rice protein (RP) on cholesterol clearance using casein‐ and RP‐based diets in growing and adult male Wistar rats over 2 weeks. RP intake significantly upregulated key genes and proteins (ABCG1, SR‐BI, LDLR, ABCG5, BSEP, CARM1, FXR) involved in cholesterol transport and metabolism, thereby enhancing cholesterol and ...
Liu B, Wang Z, Liang M, Yang L.
europepmc +2 more sources
Opposing Gatekeepers of Apical Sterol Transport: Niemann-Pick C1-Like 1 (NPC1L1) and ATP-Binding Cassette Transporters G5 and G8 (ABCG5/ABCG8) [PDF]
Immunology‚ Endocrine & Metabolic Agents in Medicinal Chemistry, 2009 Cholesterol is essential for the growth and function of all mammalian cells, but abnormally elevated levels of circulating low-density lipoprotein cholesterol (LDL-C) are a major risk factor for the development of atherosclerotic cardiovascular disease (ASCVD).
J Mark, Brown, Liqing, Yu
openaire +2 more sources
ATP-binding cassette transporter G8 M429V polymorphism as a novel genetic marker of higher cholesterol absorption in hypercholesterolaemic Japanese subjects [PDF]
Clinical Science, 2005 The ratio of serum plant sterols to cholesterol is positively correlated with the fractional cholesterol absorption, whereas serum precursors of cholesterol synthesis are positively correlated with cholesterol synthesis. Recently, two ABC (ATP-binding cassette) transporters, ABCG5 and ABCG8, have been described as playing an important role in the ...
Kenji, Miwa +9 more
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Functional Cooperativity between ABCG4 and ABCG1 Isoforms [PDF]
, 2016 ABCG4 belongs to the ABCG subfamily, the members of which are half transporters composed of a single transmembrane and a single nucleotide-binding domain.
Hegyi, Zoltán, Homolya, László
core +7 more sources
Metformin and AMP Kinase Activation Increase Expression of the Sterol Transporters ABCG5/8 (ATP-Binding Cassette Transporter G5/G8) With Potential Antiatherogenic Consequences [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2018 Objective— The mechanisms underlying the cardiovascular benefit of the anti-diabetic drug metformin are poorly understood. Recent studies have suggested metformin may upregulate macrophage reverse cholesterol transport.
Molusky, Matthew M. +7 more
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Frontiers in Cardiovascular Medicine, 2022 Sitosterolemia (OMIM ##210250), also known as phytosterolemia, is a rare autosomal recessive disorder caused by mutations in the ATP-binding cassette subfamily G member 5 (ABCG5) or member 8 (ABCG8) genes.
Ming-fang Shen +14 more
doaj +1 more source
Large Filamentous Bacteria Isolated From Sulphidic Sediments Reveal Novel Species and Distinct Energy and Defence Mechanisms for Survival. [PDF]
Environ MicrobiolIn this study, we used micromanipulation and omics to analyse 15 large filamentous bacteria collected from sulphidic sediments off Chile. We discovered novel species from various phyla, and diverse metabolic pathways and defence mechanisms were identified, highlighting their adaptability to the sediment–water interface and resilience against phage ...
Fonseca A +5 more
europepmc +2 more sources
Journal of Lipid Research, 2008 Phospholipid transfer protein (PLTP) facilitates the transfer of phospholipids from triglyceride-rich lipoproteins into HDL. PLTP has been shown to be an important factor in lipoprotein metabolism and atherogenesis. Here, we report that chronic high-fat,
Lorraine Shelly +4 more
doaj +1 more source
Ezetimibe Promotes Brush Border Membrane-to-Lumen Cholesterol Efflux in the Small Intestine. [PDF]
PLoS ONE, 2016 Ezetimibe inhibits Niemann-Pick C1-like 1 (NPC1L1), an apical membrane cholesterol transporter of enterocytes, thereby reduces intestinal cholesterol absorption.
Takanari Nakano +6 more
doaj +1 more source