Results 31 to 40 of about 2,022 (165)

Analyses of ecdysteroid transporters in the fat body of Tribolium castaneum

Insect Molecular Biology, Volume 32, Issue 4, Page 400-411, August 2023., 2023
We analysed two ABCG‐transporters and one organic anion transporting polypeptide (OATP) in Tribolium castaneum. Mutual RNAi effects observed for the tested ABCG and OATP genes indicate interdependent gene regulation. We provide RNAi and mass‐spectrometric data suggesting that these proteins are involved in ecdysteroid transport in the fat body ...
Benedikt Wellmeyer, Anna Christina Böhringer, Janin Rösner, Hans Merzendorfer   +3 more
wiley   +1 more source

Effect of graded Nrf2 activation on phase-I and -II drug metabolizing enzymes and transporters in mouse liver. [PDF]

PLoS ONE, 2012
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that induces a battery of cytoprotective genes in response to oxidative/electrophilic stress. Kelch-like ECH associating protein 1 (Keap1) sequesters Nrf2 in the cytosol.
Kai Connie Wu, Julia Yue Cui, Curtis D Klaassen   +2 more
doaj   +1 more source

Messenger RNA levels of genes involved in dysregulation of postprandial lipoproteins in type 2 diabetes: the role of Niemann–Pick C1-like 1, ATP-binding cassette, transporters G5 and G8, and of microsomal triglyceride transfer protein [PDF]

Diabetologia, 2006
The aim of the present study was to examine the relationship between chylomicron composition and expression of genes that regulate chylomicron production in the intestine. We examined expression of the following: (1) Niemann-Pick C1-like 1 (NPC1L1), which regulates cholesterol absorption; (2) ATP-binding cassette transporters G5 and G8 (ABCG5, ABCG8 ...
S, Lally, C Y, Tan, D, Owens, G H, Tomkin   +3 more
openaire   +2 more sources

A detailed Hapmap of the Sitosterolemia locus spanning 69 kb; differences between Caucasians and African-Americans [PDF]

, 2006
Background Sitosterolemia is an autosomal recessive disorder that maps to the sitosterolemia locus, STSL, on human chromosome 2p21. Two genes, ABCG5 and ABCG8, comprise the STSL and mutations in either cause sitosterolemia. ABCG5 and ABCG8 are thought to
Bhaswati Pandit, Gwang-Sook Ahn, Starr E Hazard, Derek Gordon, Shailendra B Patel, RG Gould, G Salen, AK Bhattacharyya, SB Patel, MH Lee, K Lu, KE Berge, K Lu, MH Lee, GA Graf, K Lu, H Yu, SB Gabriel, MJ Daly, DB Goldstein, N Patil, RA Hegele, AJ Jeffreys, AJ Jeffreys, K Zhang, RM Weggemans, DC Chan, JA Hubacek, K Kajinami, K Kajinami, K Kajinami, H Gylling, J Plat, K Miwa, EJ Parra, DCJ McLean, SW Guo, L Excoffier, M Stephens, K Zhang, WG Hill, RC Lewontin, GR Abecasis, D Altshuler, JM Akey, JF Wilson, SA Tishkoff, X Ke, X Sun, S Helisalmi, DB Goldstein, MH Lee, D Gordon, S Purcell, FM De La Vega, D Gordon, D Gordon, GA Graf   +57 more
core   +1 more source

Genetic inactivation of NPC1L1 protects against sitosterolemia in mice lacking ABCG5/ABCG8

Journal of Lipid Research, 2009
Mice lacking Niemann-Pick C1-Like 1 (NPC1L1) (NPC1L1−/−mice) exhibit a defect in intestinal absorption of cholesterol and phytosterols. However, wild-type (WT) mice do not efficiently absorb and accumulate phytosterols either.
Weiqing Tang, Yinyan Ma, Lin Jia, Yiannis A. Ioannou, Joanna P. Davies, Liqing Yu   +5 more
doaj   +1 more source

The alpha-glucosidase inhibitor miglitol increases hepatic CYP7A1 activity in association with altered short-chain fatty acid production in the gut of obese diabetic mice

Metabolism Open, 2020
Purpose: Bile acids (BAs) have been shown to contribute to glucose and energy homeostasis. We have recently reported that miglitol, an alpha-glucosidase inhibitor, increases fecal BA excretion and ameliorate insulin resistance and obesity in mice.
Yoji Hamada, Moritaka Goto, Go Nishimura, Hiroshi Nagasaki, Yusuke Seino, Hideki Kamiya, Jiro Nakamura   +6 more
doaj   +1 more source

The effect of silymarin on expression of selected ABC transporters in the rat

Veterinární Medicína, 2011
Silymarin (standardized extract from the seeds of the Silybum marianum) has been used in the supportive therapy of liver diseases and its cytoprotective activity is believed to be based on antioxidant properties.
R. Vecera, A. Zacharova, J. Orolin, N. Skottova, P. Anzenbacher   +4 more
doaj   +1 more source

The LOX-1 receptor ectopically expressed in the liver alleviates atherosclerosis by clearing Ox-LDL from the circulation

Molecular Medicine, 2022
Objective Oxidized Low-Density-Lipoprotein (Ox-LDL) is the core factor in the development of atherosclerosis. However, there are few therapies aimed at eliminating Ox-LDL.
Zhiwen Wang, Juan Chen, Zhuanglin Zeng, Qing Zhang, Gaohui Du, Xiaopeng Guo, Yumiao Wei   +6 more
doaj   +1 more source

ABCG5 and ABCG8 require MDR2 for secretion of cholesterol into bile

Journal of Lipid Research, 2005
The major pathway for the removal of cholesterol from the body is via secretion into the bile. Three members of the ATP binding cassette (ABC) family, ABCG5 (G5), ABCG8 (G8), and ABCB4 (MDR2), are required for the efficient biliary export of sterols ...
Silvia Langheim, Liqing Yu, Klaus von Bergmann, Dieter Lütjohann, Fang Xu, Helen H. Hobbs, Jonathan C. Cohen   +6 more
doaj   +1 more source

Dietary Soy Protein Isolate and Its Undigested High Molecular Fraction Upregulate Hepatic ATP-Binding Cassette Transporter G5 and ATP-Binding Cassette Transporter G8 mRNA and Increase Biliary Secretion of Cholesterol in Rats

Journal of Nutritional Science and Vitaminology, 2009
Dietary soy protein isolate (SPI) and its undigested high molecular fraction (HMF) exhaustively digested with proteases, compared with casein (CAS), significantly reduced serum and liver cholesterol concentration in rats. Biliary excretion of cholesterol was significantly higher in rats fed SPI and HMF than in those fed CAS.
Ikuo, Ikeda, Mariko, Kudo, Tadateru, Hamada, Koji, Nagao, Yoko, Oshiro, Masaki, Kato, Takashi, Sugawara, Takashi, Yamahira, Hiroko, Ito, Shogo, Tamaru, Masao, Sato, Katsumi, Imaizumi, Satoshi, Nagaoka, Teruyoshi, Yanagita   +13 more
openaire   +3 more sources