Biology of Cholangiocytes: From Bench to Bedside [PDF]
, 2016 Cholangiocytes, the lining epithelial cells in bile ducts, are an important subset of liver cells. They are activated by endogenous and exogenous stimuli and are involved in the modification of bile volume and composition.
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Recent advances in the exploration of the bile salt export pump (BSEP/ABCB11) function [PDF]
, 2016 ntroduction: The bile salt export pump (BSEP/ABCB11), residing in the apical membrane of hepatocyte, mediates the secretion of bile salts into the bile.
Homolya, László +1 more
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Die Genetik des Lipidstoffwechsels als Risikofaktor für kognitive Defizite bei der Parkinson-Krankheit [PDF]
, 2020 Die Parkinson-Krankheit gehört zu den Basalganglienerkrankungen und ist nach der Alzheimer-Krankheit die zweithäufigste neurodegenerative Erkrankung.
Söling, Charlotte
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An analog of glibenclamide selectively enhances autophagic degradation of misfolded α1-antitrypsin Z [PDF]
, 2019 The classical form of α1-antitrypsin deficiency (ATD) is characterized by intracellular accumulation of the misfolded variant α1-antitrypsin Z (ATZ) and severe liver disease in some of the affected individuals.
Andrew S. Chu (6256490) +12 more
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Identification of iridoid glucoside transporters in Catharanthus roseus [PDF]
, 2017 Monoterpenoid indole alkaloids (MIAs) are plant defense compounds and high-value pharmaceuticals. Biosynthesis of the universal MIA precursor, secologanin, is organized between internal phloem-associated parenchyma (IPAP) and epidermis cells ...
Colinas Martinez, Maite +9 more
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Molecular actions of hypocholesterolaemic compounds from edible mushrooms [PDF]
, 2018 Cholesterol levels are strictly regulated to maintain its homeostasis; therefore, if it is not absorbed with the diet, the cholesterol biosynthetic pathway is enhanced and vice versa.
Gil-Ramírez, Alicia +2 more
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Increased hepatobiliary and fecal cholesterol excretion upon activation of the liver X receptor is independent of ABCA1 [PDF]
, 2002 The ATP-binding cassette transporter ABCA1 is essential for high density lipoprotein (HDL) formation and considered rate-controlling for reverse cholesterol transport. Expression of the Abca1 gene is under control of the liver X receptor (LXR).
Bloks, VW +6 more
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ABC Transporters in Human Diseases [PDF]
, 2022 Mammalian ATP-binding cassette (ABC) transporters constitute a superfamily of proteins involved in many essential cellular processes. Most of these transporters are transmembrane proteins and allow the active transport of solutes, small molecules, and ...
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Role of Baicalin and Liver X Receptor Alpha in the Formation of Cholesterol Gallstones in Mice
Gastroenterology Research and Practice, 2020 This study was aimed at investigating the effect of baicalin on experimental cholesterol gallstones in mice. The mouse gallstone model was induced by feeding with a lithogenic diet, and cholesterol stones were found in the gallbladder.
Geng Chen, Shuodong Wu
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Diosgenin stimulation of fecal cholesterol excretion in mice is not NPC1L1 dependent
Journal of Lipid Research, 2009 Diosgenin exists in some food supplements and herbal medicines and lowers plasma cholesterol by increasing fecal cholesterol excretion. It is believed that diosgenin promotes fecal cholesterol excretion by stimulating biliary cholesterol secretion and ...
Ryan E. Temel +7 more
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