Results 61 to 70 of about 2,022 (165)
Disruption of the Unique ABCG-Family NBD:NBD Interface Impacts Both Drug Transport and ATP Hydrolysis [PDF]
, 2020 ABCG2 is one of a triumvirate of human multidrug ATP binding cassette (ABC) transporters that are implicated in defense of cells and tissues against cytotoxic chemicals, but which can confer chemotherapy resistance states in oncology.
Briggs, Deborah A. +3 more
core +2 more sources
A formação de HDL disfuncionais na diabetes mellitus e o risco cardiovascular [PDF]
, 2016 Monografia realizada no âmbito da unidade de Estágio Curricular do Mestrado Integrado em Ciências Farmacêuticas, apresentada à Faculdade de Farmácia da Universidade de CoimbraAs diferentes funções protetoras das lipoproteínas de alta densidade (HDL), que
Figueiredo, João Luís da Silva
core
Enhanced bioavailability of zeaxanthin in a milk-based formulation of wolfberry (Gou Qi Zi; Fructus barbarum L.) [PDF]
, 2014 Author name used in this publication: Wai Y.
Benzie, IFF +4 more
core +1 more source
PGC‐1α Activation by Polyphenols: A Pathway to Thermogenesis
Molecular Nutrition &Food Research, Volume 69, Issue 12, June 2025.Polyphenols, derived from dietary sources such as berries, undergo digestion and interact with gut microbiota, leading to their metabolization in the liver. This process influences bile acid composition, which in turn activates PGC1α, a key regulator of mitochondrial biogenesis and thermogenesis.
Nicholas Vannuchi, Luciana Pisani
wiley +1 more source
Advanced Science, Volume 12, Issue 13, April 3, 2025.Under hydrophobic bile acid pools, a “Western‐style” diet induces NAFLD and elevated bile CSI, simultaneously activating intestinal FXR to increase circulating ceramide. Hydrophobic bile acids trigger gallbladder FXR‐miR30c/e signaling, causing SDPR suppression and caveolae instability.
Hongtan Chen +7 more
wiley +1 more source
The Role of Cholesterol Metabolism and Its Regulation in Tumor Development
Cancer Medicine, Volume 14, Issue 7, April 2025.ABSTRACT Background Within the tumor microenvironment, tumor cells undergo metabolic reprogramming of cholesterol due to intrinsic cellular alterations and changes in the extracellular milieu. Furthermore, cholesterol reprogramming within this microenvironment influences the immune landscape of tumors, facilitating immune evasion and consequently ...
Yongmei Wu +5 more
wiley +1 more source
AterosclerozMutations with a decrease in the expression and function of the of the ATP-binding cassette genes proteins ABCG5 and ABCG8, as the main sterol efflux transporters, lead to the accumulation of xenosterols in plasma associated with changes in the lipid profile, hyperglycemia and the risk of cardiovascular diseases (CVD) and type 2 diabetes mellitus (DM2).
I. N. Grigor’eva +3 more
openaire +1 more source
The bile salt export pump [PDF]
, 2018 Canalicular secretion of bile salts mediated by the bile salt export pump Bsep constitutes the major driving force for the generation of bile flow.
Meier, Peter +2 more
core
Classification and Effect of Correctors on Sitosterolemia-Associated Mutants in ABCG8 [PDF]
, 2022 Objective: To classify mutants of ABCG8 identified in subjects with clinically confirmed Sitosterolemia, a rare form of Familial Hypercholesterolemia distinguished by the accumulation of phytosterols in plasma and tissues and determine the effects of ...
Poole, Brittney
core +1 more source
Flavonoids, gut microbiota, and host lipid metabolism
Engineering in Life Sciences, Volume 24, Issue 5, May 2024.Abstract Flavonoids are widely distributed in nature and have a variety of beneficial biological effects, including antioxidant, anti‐inflammatory, and anti‐obesity effects. All of these are related to gut microbiota, and flavonoids also serve as a bridge between the host and gut microbiota. Flavonoids are commonly used to modify the composition of the
Miao Zhou +6 more
wiley +1 more source