Results 61 to 70 of about 1,805,873 (166)

Investigation of the Function and Regulation of ABC Transporters [PDF]

, 2014
The copyright of this thesis rests with the author and no quotation from it or information derived from it may be published without the prior written consent of the authorATP-Binding-Cassette (ABC) transporters are primary active pumps that typically ...
Akkaya, Begum Gokcen
core   +1 more source

Laminaria japonica Aresch-Derived Fucoidan Ameliorates Hyperlipidemia by Upregulating LXRs and Suppressing SREBPs

Cardiovascular Therapeutics
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide, and hyperlipidemia is one major inducing factor of CVD. It is worthy to note that fucoidans are reported to have hypolipidemic activity with species specificity ...
Yan Zhang, Tian Liu, Ze-Jie Qu, Xue Wang, Wen-Gang Song, Shou-Dong Guo   +5 more
doaj   +1 more source

PGC‐1α Activation by Polyphenols: A Pathway to Thermogenesis

Molecular Nutrition &Food Research, Volume 69, Issue 12, June 2025.
Polyphenols, derived from dietary sources such as berries, undergo digestion and interact with gut microbiota, leading to their metabolization in the liver. This process influences bile acid composition, which in turn activates PGC1α, a key regulator of mitochondrial biogenesis and thermogenesis.
Nicholas Vannuchi, Luciana Pisani
wiley   +1 more source

A Gallbladder‐Specific Hydrophobic Bile Acid‐FXR‐MUC1 Signaling Axis Mediates Cholesterol Gallstone Formation

Advanced Science, Volume 12, Issue 13, April 3, 2025.
Under hydrophobic bile acid pools, a “Western‐style” diet induces NAFLD and elevated bile CSI, simultaneously activating intestinal FXR to increase circulating ceramide. Hydrophobic bile acids trigger gallbladder FXR‐miR30c/e signaling, causing SDPR suppression and caveolae instability.
Hongtan Chen, Xin Jiang, Yiqiao Li, Honggang Guo, Jianguo Wu, Sha Li, Fengling Hu, Guoqiang Xu   +7 more
wiley   +1 more source

Transmembrane Polar Relay Drives the Allosteric Regulation for ABCG5/G8 Sterol Transporter

, 2020
The heterodimeric ATP-binding cassette (ABC) sterol transporter, ABCG5/G8, is responsible for the biliary and transintestinal secretion of cholesterol and dietary plant sterols.
Aiman A. Zein, Angelica Venes, Junmei Wang, Jyh-Yeuan Lee, Bala M. Xavier   +4 more
core   +1 more source

The Role of Cholesterol Metabolism and Its Regulation in Tumor Development

Cancer Medicine, Volume 14, Issue 7, April 2025.
ABSTRACT Background Within the tumor microenvironment, tumor cells undergo metabolic reprogramming of cholesterol due to intrinsic cellular alterations and changes in the extracellular milieu. Furthermore, cholesterol reprogramming within this microenvironment influences the immune landscape of tumors, facilitating immune evasion and consequently ...
Yongmei Wu, Wenqian Song, Min Su, Jing He, Rong Hu, Youbo Zhao   +5 more
wiley   +1 more source

Induction of the intestinal membrane transporters ABCA1 and ABCG8 by 27-hydroxycholesterol through a redox mechanism

Redox Experimental Medicine
Objective: We tested the effect of 27-hydroxycholesterol (27OHC) on the expression and synthesis of two membrane transporters involved in sterols extrusion from the intestinal epithelium into the gut lumen: ATP-binding cassette A1 (ABCA1) and G8 (ABCG8).
Noemi Iaia, Valerio Leoni, Giuseppe Poli, Fiorella Biasi   +3 more
doaj   +1 more source

Large Filamentous Bacteria Isolated From Sulphidic Sediments Reveal Novel Species and Distinct Energy and Defence Mechanisms for Survival

Environmental Microbiology, Volume 27, Issue 3, March 2025.
In this study, we used micromanipulation and omics to analyse 15 large filamentous bacteria collected from sulphidic sediments off Chile. We discovered novel species from various phyla, and diverse metabolic pathways and defence mechanisms were identified, highlighting their adaptability to the sediment–water interface and resilience against phage ...
Alexis Fonseca, Thomas Ishoey, Carola Espinoza, Ian P. G. Marshall, Lars Peter Nielsen, Victor Ariel Gallardo   +5 more
wiley   +1 more source

An in vitro set‐up to study Pdr5‐mediated substrate translocation

Protein Science, Volume 33, Issue 10, October 2024.
Abstract Pdr5 is the most abundant ABC transporter in Saccharomyces cerevisiae and plays a major role in the pleiotropic drug resistance (PDR) network, which actively prevents cell entry of a large number of structurally unrelated compounds. Due to a high level of asymmetry in one of its nucleotide binding sites (NBS), Pdr5 serves as a perfect model ...
Stefanie L. Gala Marti, Manuel Wagner, Lea‐Marie Nentwig, Sander H. J. Smits, Lutz Schmitt   +4 more
wiley   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source