Results 51 to 60 of about 2,022 (165)
Differences in synthesis and absorption of cholesterol of two effective lipid-lowering therapies [PDF]
, 2012 Effective statin therapy is associated with a marked reduction of cardiovascular events. However, the explanation for full benefits obtained for LDL cholesterol targets by combined lipid-lowering therapy is controversial.
Borges, Ney Carter do Carmo +9 more
core +2 more sources
The FASEB Journal, 2006 Objective To determine the effect of polymorphisms ABCG5 and ABCG8 transporters on changes in lipid levels, cholesterol absorption rate (ABS), fractional synthesis rate (FSR), and turnover (TO) after moderate weight loss (WL) in women. Design
Sylvia Santosa +4 more
openaire +1 more source
3D structure of the transporter ABCG2 : what's new? [PDF]
, 2020 ABCG2 belongs to the ABC transporter superfamily and functions as a poly-specific efflux pump. As it can transport a broad spectrum of substrates out of cells, ABCG2 is thought to alter the pharmacokinetics of drugs applied to treat certain diseases ...
Benndorf, Ralf, Eckenstaler, Robert
core +1 more source
Emerging therapeutic strategies to enhance HDL function [PDF]
, 2011 Epidemiologic studies indicate a strong inverse correlation between plasma levels of high-density lipoproteins (HDL) and cardiovascular disease (CVD).
Martínez-González, José +4 more
core +4 more sources
Journal of Food Biochemistry, Volume 2026, Issue 1, 2026.Hyperlipidemia is recognized as a major contributor to chronic noncommunicable diseases. The primary strategy regarding hyperlipidemia prevention is involved in the blockade of intestinal cholesterol absorption. Ezetimibe (Eze) is the sole prescribed drug that targets Niemann‐Pick C1 Like 1 (NPC1L1), a key cholesterol transporter, resulting in reduced ...
Jakkapong Inchai +8 more
wiley +1 more source
Effect of Taurodehydrocholic Acid on the Hepatic Expression of Abcg5 and Abcg8 and Biliary Parameters in the Fistula Rat [PDF]
Introduction: Biliary secretion of phospholipids and cholesterol is mainly dependent on bile-salt secretion although the exact mechanisms involved are not clearly defined.
Hismiogullari, AA +4 more
core +1 more source
Description of Prototype Modes-of-Action Related to Repeated Dose Toxicity [PDF]
, 2012 This report presents the definition and detailed documentation of chosen toxicological MoAs associated with repeated dose target organ toxicity as a first step in building a "prototype" safety assessment framework.
GOUMENOU MARINA - PARESKEVI +3 more
core +1 more source
The Plant Journal, Volume 124, Issue 2, October 2025.Significance Statement The promoter of the METE gene in the diatom Phaeodactylum tricornutum is repressed by nanomolar concentrations of vitamin B12. It can be used to tune the expression of genes for reporter proteins or metabolic enzymes and in the non‐permissive state (i.e., +B12) can suppress the expression of the lethal gene, barnase.
Patrick R. Hickland +8 more
wiley +1 more source
Assessing the effect of statins in lowering the risk of stroke and preventing cerebral ischemia in patients with hypercholesterolemia [PDF]
, 2017 Numerous analyses have explored the role of statins in reducing stroke incidence, reducing cerebral ischemia in hypercholesterolemic patients, and preventing ischemic stroke.
AlSulaiman, Wafa
core
Clinical and Translational Discovery, Volume 5, Issue 4, August 2025.For patients with unexplained haemolytic anaemia, thrombocytopenia, especially with stomatocytes present in peripheral blood, the diagnosis of sitosterolemia should be considered, and genetic testing is strongly recommended . Abstract Background Sitosterolemia is a rare, inherited, autosomal recessive disorder of lipid metabolism.
Mengjia Qian +9 more
wiley +1 more source