Results 21 to 30 of about 2,022 (165)

Ezetimibe therapy: mechanism of action and clinical update. [PDF]

, 2012
The lowering of low-density lipoprotein cholesterol (LDL-C) is the primary target of therapy in the primary and secondary prevention of cardiovascular events.
Dayspring, Thomas D, Phan, Binh An P, Toth, Peter P   +2 more
core   +1 more source

Ezetimibe normalizes metabolic defects in mice lacking ABCG5 and ABCG8

Journal of Lipid Research, 2005
The ATP binding cassette transporters ABCG5 (G5) and ABCG8 (G8) limit the accumulation of neutral sterols by restricting sterol uptake from the intestine and promoting sterol excretion into bile.
Liqing Yu, Klaus von Bergmann, Dieter Lütjohann, Helen H. Hobbs, Jonathan C. Cohen   +4 more
doaj   +1 more source

Effects of dietary alfalfa saponins on laying performance, egg cholesterol concentration, and ATP-binding cassette transporters G5 and G8 expression in laying hens [PDF]

Journal of Applied Animal Research, 2018
This experiment was designed to evaluate the potential for dietary alfalfa saponins (AS) to influence cholesterol (Ch) concentrations and the mRNA expressions of the ATP-binding cassette (ABC) that concludes transporters G5 (ABCG5) and G8 (ABCG8) in the livers of laying hens. Hundred and fifty laying hens (27 weeks old) were divided into five treatment
Wenna Fan, Xian-lei Zhang, Pengfei Shi, Jia Li, Cheng-zhang Wang, De-feng Li, Xiao-yan Zhu   +6 more
openaire   +2 more sources

Residues contributing to drug transport by ABCG2 are localised to multiple drug-binding pockets [PDF]

, 2018
Multidrug binding and transport by the ATP binding cassette transporter ABCG2 is a factor in the clinical resistance to chemotherapy in leukaemia, and a contributory factor to the pharmacokinetic profiles of many other prescribed drugs.
Allen, Allikmets, Alqawi, Boussif, Clark, Cunningham, Deborah A. Briggs, Doyle, Ejendal, Ferreira, Ferreira, Gál, Haider, Higgins, Horsey, Ian D. Kerr, Johnson, Kage, Kerr, Khunweeraphong, Laemmli, Lawson, Lee, Li, Liu, Loo, Loo, Loo, László, Mao, McDevitt, McDevitt, Megan H. Cox, Mittra, Miyake, Nakashima, Ni, Ni, Nikaido, Parth Kapoor, Pleban, Robey, Robey, Rosenberg, Rosenberg, Seeger, Tamaki, Tamura, Tamura, Taylor, Trott, Verhalen, Wan, Wehenkel, Wong, Wong, Woodward, Wu, Xu, Özvegy-Laczka   +59 more
core   +2 more sources

A Versatile Synaptotagmin‐1 Nanobody Provides Perturbation‐Free Live Synaptic Imaging And Low Linkage‐Error in Super‐Resolution Microscopy

Small Methods, Volume 7, Issue 10, October 20, 2023., 2023
Selection, characterization, and development of a nanobody that strongly and selectively binds the C2A domain of synaptotagmin‐1, providing unparalleled imaging accuracy in various super‐resolution imaging techniques. It also functions as an intrabody in living neurons while preserving synaptic vesicle physiology, enabling precise spatiotemporal ...
Karine Queiroz Zetune Villa Real, Nikolaos Mougios, Ronja Rehm, Shama Sograte‐Idrissi, László Albert, Amir Mohammad Rahimi, Manuel Maidorn, Jannik Hentze, Markel Martínez‐Carranza, Hassan Hosseini, Kim‐Ann Saal, Nazar Oleksiievets, Matthias Prigge, Roman Tsukanov, Pål Stenmark, Eugenio F. Fornasiero, Felipe Opazo   +16 more
wiley   +1 more source

Decreased NPC1L1 expression in the liver from Chinese female gallstone patients [PDF]

, 2010
Background Cholesterol gallstone disease is a very common disease in both industrialized and developing countries. Many studies have found that cholesterol gallstones are more common in women than men. The molecular mechanisms underlying the relationship
Wei Cui, Zhao-Yan Jiang, Qu Cai, Ru-Yuan Zhang, Wei-Ze Wu, Jian-Cheng Wang, Jian Fei, Sheng-Dao Zhang, Tian-Quan Han   +8 more
core   +2 more sources

Deciphering structural aspects of reverse cholesterol transport: mapping the knowns and unknowns

Biological Reviews, Volume 98, Issue 4, Page 1160-1183, August 2023., 2023
ABSTRACT Atherosclerosis is a major contributor to the onset and progression of cardiovascular disease (CVD). Cholesterol‐loaded foam cells play a pivotal role in forming atherosclerotic plaques. Induction of cholesterol efflux from these cells may be a promising approach in treating CVD.
Sukriti Sacher, Abhishek Mukherjee, Arjun Ray   +2 more
wiley   +1 more source

Stanol esters decrease plasma cholesterol independently of intestinal ABC sterol transporters and Niemann-Pick C1-like 1 protein gene expression

Journal of Lipid Research, 2004
Possible mechanisms for the cholesterol-lowering effects of plant stanol esters were addressed by feeding hamsters diets containing stanol esters, cholesterol, or cholestyramine/lovastatin.
F. Jeffrey Field, Ella Born, Satya N. Mathur   +2 more
doaj   +1 more source

An in vitro set-up to study Pdr5-mediated substrate translocation. [PDF]

Protein Sci
Abstract Pdr5 is the most abundant ABC transporter in Saccharomyces cerevisiae and plays a major role in the pleiotropic drug resistance (PDR) network, which actively prevents cell entry of a large number of structurally unrelated compounds. Due to a high level of asymmetry in one of its nucleotide binding sites (NBS), Pdr5 serves as a perfect model ...
Gala Marti SL, Wagner M, Nentwig LM, Smits SHJ, Schmitt L.   +4 more
europepmc   +2 more sources

Sitosterolemia: Twenty Years of Discovery of the Function of \u3ci\u3eABCG5ABCG8\u3c/i\u3e [PDF]

, 2021
Sitosterolemia is a lipid disorder characterized by the accumulation of dietary xenosterols in plasma and tissues caused by mutations in either ABCG5 or ABCG8. ABCG5 ABCG8 encodes a pair of ABC half transporters that form a heterodimer (G5G8), which then
Graf, Gregory A., Segard, Allison, Williams, Kori   +2 more
core   +2 more sources