Results 21 to 30 of about 1,805,873 (166)

Rustless translation [PDF]

, 2012
ATP binding cassette proteins are a large and diverse family of molecular machines and include transmembrane transporter, chromosome maintenance and DNA repair proteins, and translation factors.
Hopfner, Karl-Peter
core   +1 more source

Stanol esters decrease plasma cholesterol independently of intestinal ABC sterol transporters and Niemann-Pick C1-like 1 protein gene expression

Journal of Lipid Research, 2004
Possible mechanisms for the cholesterol-lowering effects of plant stanol esters were addressed by feeding hamsters diets containing stanol esters, cholesterol, or cholestyramine/lovastatin.
F. Jeffrey Field, Ella Born, Satya N. Mathur   +2 more
doaj   +1 more source

Cholesterol feeding strongly reduces hepatic VLDL-triglyceride production in mice lacking the liver X receptor αs⃞

Journal of Lipid Research, 2007
The oxysterol-activated nuclear receptor liver X receptor α (LXRα) has been implicated in the control of both cholesterol and fatty acid metabolism.
Jelske N. van der Veen, Rick Havinga, Vincent W. Bloks, Albert K. Groen, Folkert Kuipers   +4 more
doaj   +1 more source

Effect of graded Nrf2 activation on phase-I and -II drug metabolizing enzymes and transporters in mouse liver. [PDF]

PLoS ONE, 2012
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that induces a battery of cytoprotective genes in response to oxidative/electrophilic stress. Kelch-like ECH associating protein 1 (Keap1) sequesters Nrf2 in the cytosol.
Kai Connie Wu, Julia Yue Cui, Curtis D Klaassen   +2 more
doaj   +1 more source

Messenger RNA levels of genes involved in dysregulation of postprandial lipoproteins in type 2 diabetes: the role of Niemann–Pick C1-like 1, ATP-binding cassette, transporters G5 and G8, and of microsomal triglyceride transfer protein [PDF]

Diabetologia, 2006
The aim of the present study was to examine the relationship between chylomicron composition and expression of genes that regulate chylomicron production in the intestine. We examined expression of the following: (1) Niemann-Pick C1-like 1 (NPC1L1), which regulates cholesterol absorption; (2) ATP-binding cassette transporters G5 and G8 (ABCG5, ABCG8 ...
S, Lally, C Y, Tan, D, Owens, G H, Tomkin   +3 more
openaire   +2 more sources

Genetic inactivation of NPC1L1 protects against sitosterolemia in mice lacking ABCG5/ABCG8

Journal of Lipid Research, 2009
Mice lacking Niemann-Pick C1-Like 1 (NPC1L1) (NPC1L1−/−mice) exhibit a defect in intestinal absorption of cholesterol and phytosterols. However, wild-type (WT) mice do not efficiently absorb and accumulate phytosterols either.
Weiqing Tang, Yinyan Ma, Lin Jia, Yiannis A. Ioannou, Joanna P. Davies, Liqing Yu   +5 more
doaj   +1 more source

The alpha-glucosidase inhibitor miglitol increases hepatic CYP7A1 activity in association with altered short-chain fatty acid production in the gut of obese diabetic mice

Metabolism Open, 2020
Purpose: Bile acids (BAs) have been shown to contribute to glucose and energy homeostasis. We have recently reported that miglitol, an alpha-glucosidase inhibitor, increases fecal BA excretion and ameliorate insulin resistance and obesity in mice.
Yoji Hamada, Moritaka Goto, Go Nishimura, Hiroshi Nagasaki, Yusuke Seino, Hideki Kamiya, Jiro Nakamura   +6 more
doaj   +1 more source

ABCG5 and ABCG8 require MDR2 for secretion of cholesterol into bile

Journal of Lipid Research, 2005
The major pathway for the removal of cholesterol from the body is via secretion into the bile. Three members of the ATP binding cassette (ABC) family, ABCG5 (G5), ABCG8 (G8), and ABCB4 (MDR2), are required for the efficient biliary export of sterols ...
Silvia Langheim, Liqing Yu, Klaus von Bergmann, Dieter Lütjohann, Fang Xu, Helen H. Hobbs, Jonathan C. Cohen   +6 more
doaj   +1 more source

The LOX-1 receptor ectopically expressed in the liver alleviates atherosclerosis by clearing Ox-LDL from the circulation

Molecular Medicine, 2022
Objective Oxidized Low-Density-Lipoprotein (Ox-LDL) is the core factor in the development of atherosclerosis. However, there are few therapies aimed at eliminating Ox-LDL.
Zhiwen Wang, Juan Chen, Zhuanglin Zeng, Qing Zhang, Gaohui Du, Xiaopeng Guo, Yumiao Wei   +6 more
doaj   +1 more source

Diet-induced Lipid Accumulation in Liver Enhances ATP-binding Cassette Transporter g5/g8 Expression in Bile Canaliculi

Drug Metabolism and Pharmacokinetics, 2011
The ATP-binding cassette half-transporters Abcg5 and Abcg8 promote the secretion of neutral sterols into bile. Studies have demonstrated the diet-induced expression of these transporters in liver, but precisely where this occurs remains to be elucidated.
YAMAZAKI, Yasuhiro, HASHIZUME, Takahiro, MORIOKA, Hiroko, SADAMITSU, Satoshi, IKARI, Akira, MIWA, Masao, SUGATANI, Junko   +6 more
openaire   +2 more sources