Results 21 to 30 of about 1,808,366 (209)

ATP-binding cassette transporter A1: From metabolism to neurodegeneration

Neurobiology of Disease, 2014
ATP-binding cassette transporter A1 (ABCA1) mediates cholesterol efflux to lipid-free apolipoprotein A-I (apoA-I) and apolipoprotein E (apoE). ABCA1 is an essential regulator of high density lipoproteins (HDL) and reverse cholesterol transport — a role ...
Radosveta Koldamova, Nicholas F. Fitz, Iliya Lefterov   +2 more
doaj   +1 more source

Stanol esters decrease plasma cholesterol independently of intestinal ABC sterol transporters and Niemann-Pick C1-like 1 protein gene expression

Journal of Lipid Research, 2004
Possible mechanisms for the cholesterol-lowering effects of plant stanol esters were addressed by feeding hamsters diets containing stanol esters, cholesterol, or cholestyramine/lovastatin.
F. Jeffrey Field, Ella Born, Satya N. Mathur   +2 more
doaj   +1 more source

Identification and characterisation of putative drug binding sites in human ATP-binding cassette B5 (ABCB5) transporter [PDF]

, 2021
The human ATP-binding cassette B5 (ABCB5) transporter, a member of the ABC transporter superfamily, is linked to chemoresistance in tumour cells by drug effluxion. However, little is known about its structure and drug-binding sites.
Deplazes, E, Gray, ES, Arooj, M, Mancera, RL, Tangella, LP, Elin S. Gray, Ricardo L. Mancera, Tangella, Lokeswari P., Lokeswari P. Tangella, Evelyne Deplazes, Mancera, Ricardo L., Gray, Elin S., Deplazes, Evelyne, Mahreen Arooj, Arooj, Mahreen   +14 more
core   +2 more sources

ABCG1 regulates mouse adipose tissue macrophage cholesterol levels and ratio of M1 to M2 cells in obesity and caloric restriction

Journal of Lipid Research, 2015
In addition to triacylglycerols, adipocytes contain a large reserve of unesterified cholesterol. During adipocyte lipolysis and cell death seen during severe obesity and weight loss, free fatty acids and cholesterol become available for uptake and ...
Hao Wei, Elizabeth J. Tarling, Timothy S. McMillen, Chongren Tang, Renée C. LeBoeuf   +4 more
doaj   +1 more source

A single power stroke by ATP binding drives substrate translocation in a heterodimeric ABC transporter

eLife, 2020
ATP-binding cassette (ABC) transporters constitute the largest family of primary active transporters, responsible for many physiological processes and human maladies.
Erich Stefan, Susanne Hofmann, Robert Tampé   +2 more
doaj   +1 more source

CLONING OF A GENE ENCODING PROTEIN BELONGING TO ABC TRANSPORTER INVOLVED IN BACTERIAL MAGNETIC PARTICLE SYNTHESIS IN MAGNETOSPIRILLUM MAGNETICUM AMB-1

Biotropia: The Southeast Asian Journal of Tropical Biology, 2009
Magnetospirillum magneticum AMB-1 synthesizes intracellular magnetic particles, magnetite (Fe3 O4 ), enveloped by membrane called magnetosome under micro-aerobic conditions.
ARIS TRI WAHYUDI
doaj   +1 more source

A-subclass ATP-binding cassette proteins in brain lipid homeostasis and neurodegeneration

Frontiers in Psychiatry, 2012
The A-subclass of ATP-binding cassette (ABC) transporters comprises twelve structurally related members of the evolutionarily highly conserved superfamily of ABC transporters.
Armin P. Piehler, Armin P. Piehler, Mustafa eÖzçürümez, Wolfgang E. Kaminski   +3 more
doaj   +1 more source

Solid-state NMR Reveals Asymmetric ATP hydrolysis in the Multidrug ABC Transporter BmrA [PDF]

, 2022
The detailed mechanism of ATP hydrolysis in ATP-binding cassette (ABC) transporters is still not fully understood. Here, we employed 31P solid-state NMR to probe the conformational changes and dynamics during the catalytic cycle by locking the multidrug ...
Denis, Lacabanne, Matthias, Ernst, Jean-Michel, Jault, Beat H., Meier, Anja, Böckmann, Margot, Di Cesare, Cédric, Orelle, Thomas, Wiegand, Cédric Orelle, Denis Lacabanne, Thomas Wiegand, Jean-Michel Jault, Margot Di Cesare, Anja Böckmann, Matthias Ernst, Beat H. Meier   +15 more
core   +2 more sources

Investigation of the Function and Regulation of ABC Transporters [PDF]

, 2014
The copyright of this thesis rests with the author and no quotation from it or information derived from it may be published without the prior written consent of the authorATP-Binding-Cassette (ABC) transporters are primary active pumps that typically ...
Akkaya, Begum Gokcen
core   +2 more sources

Association of Genetic Variants With Rivaroxaban Pharmacokinetics and Pharmacodynamics in Older Patients With Atrial Fibrillation: A Prospective Cohort Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Rivaroxaban is frequently used for stroke prevention in atrial fibrillation. Clinicians increasingly encounter complex decision‐making regarding oral anticoagulant prescription in older patients with atrial fibrillation.
Guoquan Chen, Haiping Wang, Jiale Chen, Ling Wang, Qiang Zhao, Ganbo Que, Wenchang Zhang, Shuqiao Hu, Wei Hu, Congli Hu   +9 more
doaj   +1 more source