Results 61 to 70 of about 56,913 (295)
Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities
AGING MEDICINE, EarlyView.Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley +1 more source
The Modulatory Role of CYP3A4 in Dictamnine-Induced Hepatotoxicity [PDF]
, 2018 Dictamni Cortex (DC) has been reported to be associated with acute hepatitis in clinic and may lead to a selective sub-chronic hepatotoxicity in rats. Nevertheless, the potent toxic ingredient and the underlying mechanism remain unknown. Dictamnine (DTN),
Dong-Sheng Zhao +9 more
core +1 more source
Effect of verapamil on the pharmacokinetics of hydroxycamptothecin and its potential mechanism
Pharmaceutical Biology, 2020 Context Hydroxycamptothecin (HCPT) has antitumor activity in various cancers, but its poor bioavailability and efflux limit its clinical application. Verapamil has been demonstrated to improve the bioavailability of many drugs.
Hua Xing +6 more
doaj +1 more source
ASM Science Journal, 2022 The cytochrome P450 (CYP) enzymes are of a ubiquitous heme–thiolate proteins family that plays an important role within the biotransformation of endogenous molecules and xenobiotics as today’s market is bio-transformed through CYP-mediated metabolism ...
Fazleen Haslinda Mohd Hatta +4 more
doaj +1 more source
Advanced Intelligent Discovery, EarlyView.Artificial intelligence is redefining network pharmacology (NP). By integrating knowledge graph engineering, geometric deep learning, multiomics anchoring, and generative reasoning, AI‐driven NP (AI‐NP) transforms static target mapping into dynamic, predictive modeling.
Cong Wang +9 more
wiley +1 more source
The CYP3A4*3 Allele: Is It Really Rare? [PDF]
Clinical Chemistry, 2001 Enzymes of the cytochrome P450 system are involved in the metabolism of a broad range of foreign compounds, such as drugs, environmental pollutants, and carcinogens (1). The most abundant enzyme in the human liver is cytochrome P450 3A4 (CYP3A4) (2).
R H, van Schaik +5 more
openaire +2 more sources
Biofuels, Bioproducts and Biorefining, EarlyView.Abstract The growing global demand for sustainable energy solutions has intensified the search for renewable alternatives to fossil fuels, with biodiesel emerging as a promising candidate due to its biodegradability and lower emissions. However, its large‐scale application is limited by low oxidative stability, which compromises storage and performance.
Patricia R. S. Wenceslau +10 more
wiley +1 more source
Superposition of P450cam and CYP3A4.
, 2013 a) Top row: superimposed ribbon diagrams of P450cam (1DZ4) and CYP3A4 (1TQN). P450cam is shown with red helices and yellow sheets, whereas CYP3A4 is shown all in pink. The porphyrin for P450cam is shown in gray and the one for CYP3A4, in brown.
Derrick J. Mah (407114) +3 more
core +1 more source
British Journal of Clinical Pharmacology, EarlyView.While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis +5 more
wiley +1 more source
Unique CYP3A4 genetic variant in Brazilian tuberculosis patients with/without HIV
, 2011 CYP3A4 is involved in tuberculosis (TB) and human immunodeficiency virus (HIV) drug metabolism. Transcriptional activation by rifampicin involves the CYP3A4 gene 5'-upstream region.
El-Jaick, Kênia B. +6 more
core +1 more source