Results 71 to 80 of about 76,948 (211)

The Effects of Pregnenolone 16α-Carbonitrile Dosing on Digoxin Pharmacokinetics and Intestinal Absorption in the Rat [PDF]

, 2010
The effect of Pgp induction in rats by pregnenolone 16α-carbonitrile (PCN) (3 days, 35 mg/kg/d, p.o.) on digoxin pharmacokinetics and intestinal transport has been assessed.
Anna-Lena Ungell, Bauer, Britt-Marie Fihn, Constanze Hilgendorf, Englund, Harrison, Iain S. Haslam, Johan E. Karlsson, Lam, Nicholas L. Simmons, Noe, Read, Simon Lowes   +12 more
core   +2 more sources

In vitro inhibitory effects of cepharanthine on human liver cytochrome P450 enzymes

Pharmaceutical Biology, 2020
Context Cepharanthine (CEP) extracted from the roots of Stephania cepharantha Hayata (Menispermaceae), has a range of therapeutic potential in clinical conditions.
Xunge Zhang, Ping Feng, Xinfu Gao, Bin Wang, Chunxia Gou, Ruimin Bian   +5 more
doaj   +1 more source

Transcriptional Regulation and Expression of CYP3A4 in Hepatocytes

Current Drug Metabolism, 2007
CYP3A4 is the most abundantly expressed drug-metabolizing P450 enzyme in human liver and contributes to the metabolism of a large number of drugs in use today. CYP3A4 is constitutively expressed in adult hepatocytes but it can also be transcriptionally induced by a variety of structurally diverse xenochemicals.
Martinez Jimenez, Celia Pilar, Jover Atienza, Ramiro, Donato Martín, María Teresa, Castell, José V., Gómez Lechón-Moliner, María José   +4 more
openaire   +4 more sources

Functional assessment of CYP3A4 allelic variants on lidocaine metabolism in vitro

Drug Design, Development and Therapy, 2017
Ping Fang,1 Peng-fei Tang,1 Ren-ai Xu,2 Xiang Zheng,1 Jian Wen,1 Su-su Bao,1 Jian-ping Cai,3 Guo-xin Hu1 1Department of Pharmacology, School of Pharmacy, Wenzhou Medical University, 2Department of Pharmacy, The First Affiliated Hospital of Wenzhou ...
Fang P, Tang P, Xu R, Zheng X, Wen J, Bao S, Cai J, Hu G   +7 more
doaj  

7‑hydroxymitragynine is an active metabolite of mitragynine and a key mediator of its analgesic effects [PDF]

, 2019
Mitragynina speciosa, more commonly known as kratom, is a plant native to Southeast Asia, the leaves of which have been used traditionally as a stimulant, analgesic, and treatment for opioid addiction.
Ansonoff, Michael, Gassaway, Madalee M., Grinnell, Steven G., Javitch, Jonathan A., Kruegel, Andrew C., Langreck, Cory, Le Rouzic, Valerie, Majumdar, Susruta, Pasternak, Gavril W., Pekarskaya, Elizabeth A., Pintar, John E., Sames, Dalibor, Uprety, Rajendra   +12 more
core   +3 more sources

Influence of verapamil on the pharmacokinetics of oridonin in rats

Pharmaceutical Biology, 2019
Context: Oridonin has been traditionally used in Chinese treatment of various cancers, but its poor bioavailability limits its therapeutic uses. Verapamil can enhance the absorption of some drugs with poor oral bioavailability.
Jing Liu, Ning Zhang, Na Li, Xiaocheng Fan, Ying Li   +4 more
doaj   +1 more source

Inhibition of CYP3A4 by 6′,7′-dihydroxybergamottin in human CYP3A4 over-expressed hepG2 cells

Journal of Pharmacy and Pharmacology, 2012
AbstractObjectivesWe previously established HepG2-GS-3A4, a cell line from hepatoblastoma with overexpression of human CYP3A4 and glutamine synthetase (GS). We further reported that these cells can be applied for screening inhibitors of CYP3A4 in vitro.
Nobutaka, Araki, Shuichi, Tsuruoka, Gohki, Hasegawa, Hayato, Yanagihara, Takeshi, Omasa, Shin, Enosawa, Yasushi, Yamazoe, Akio, Fujimura   +7 more
openaire   +2 more sources

Xenobiotic metabolism: the effect of acute kidney injury on non-renal drug clearance and hepatic drug metabolism. [PDF]

, 2014
Acute kidney injury (AKI) is a common complication of critical illness, and evidence is emerging that suggests AKI disrupts the function of other organs.
Abosaif, Andres-Hernando, Andres-Hernando, Barbara Philips, Boucher, Bougle, Brown, Chan, Chawla, Chung, Doi, Dowling, Dreisbach, Dreisbach, English, Fadillioglu, Gardiner, Gertz, Golab, Group, Gurley, Hassoun, Heinemeyer, Heinemeyer, Iain MacPhee, Izuwa, John Dixon, Karim, Katie Lane, Kirwan, Kirwan, Klein, Kramer, Krueger, Kunihara, Kunuzova, Lane, Lash, Leblanc, Lee, Lee, Lohr, Martyn, Mastorakos, Meier-Hellmann, Michaud, Michaud, Miyazawa, Muntane-Relat, Murakami, Naud, Naud, Nicholson, Nolin, Nolin, Okabe, Okabe, Okabe, Owen, O’Shaunessy, Park, Park, Philips, Power, Schneider, Serteser, Shi, Shibata, Smith, Soni, Spapen, Srinivas, Sun, Tanabe, Tian, Venkatesh, Wang, Whelton, Wilkinson, Wilson, Yamaguchi, Yoshitani, Yu   +82 more
core   +2 more sources

Analysis of variants in the HCN4 gene and in three single nucleotide polymorphisms of the CYP3A4 gene for association with ivabradine reduction in heart rate: a preliminary report [PDF]

, 2016
[Abstract] Background: Ivabradine, a selective bradycardic drug, inhibits the If. In patients with heart failure (HF), ivabradine reduces the risk of rehospitalization and mortality.
Barge-Caballero, Eduardo, Crespo-Leiro, María Generosa, Grille Cancela, Zulaika, Hermida-Prieto, Manuel, Marrón Liñares, Grecia Manuela, Marzoa Rivas, Raquel, Muñiz, Javier, Núñez, Lucía, Paniagua-Martín, María J., Suárez-Fuentetaja, Natalia, Vázquez-Rodríguez, José Manuel   +10 more
core   +2 more sources

Safety and efficacy of vismodegib in patients aged ≥65 years with advanced basal cell carcinoma. [PDF]

, 2016
Because many patients with unresectable basal cell carcinoma (BCC) are aged ≥65 years, this study explores the efficacy and safety of vismodegib in these patients with locally advanced (la) or metastatic (m) basal cell carcinoma (BCC) in the ERIVANCE BCC
Arron, Sarah, Chang, Anne, Day, Bann-Mo, Lewis, Karl, McKenna, Edward, Migden, Michael, Sekulic, Aleksandar, Solomon, James, Yoo, Simon   +8 more
core   +2 more sources