Results 71 to 80 of about 43,637 (267)

Clozapine:norclozapine ratio as a marker of metabolic risk and therapeutic response and effect of valproate on clozapine levels

British Journal of Clinical Pharmacology, EarlyView.
Aims Clozapine is the most effective antipsychotic in treatment‐resistant schizophrenia. Clozapine causes weight gain and increased diabetes risk. The role of its metabolite norclozapine and clozapine:norclozapine ratio (CLZ/NCLZ) in metabolic effects has been debated.
Susanna Maria Rask, Miina Lamminmäki, Olli Kampman, Mari Hämäläinen, Eeva Moilanen, Niko Seppälä, Anssi Solismaa   +6 more
wiley   +1 more source

Genetic polymorphism of CYP3A4 associated with reduced response to statin therapy in Pakistani cardiac and dyslipidemic patients: A cross-sectional observational study

Pakistan Journal of Pharmaceutical Sciences
Background: Drug resistance phenomenon has become a serious problem in the lipid lowering drugs in the treatment of cardiac and dyslipidemic patients. Statins are the mainstay pharmacological treatment for dyslipidemia, metabolized by CYP3A4 gene. CYP3A4
Hafiz Rafay Rawaal, Amina Arif, Adil Jamal, Kashif- ur- Rehman   +3 more
doaj   +1 more source

Succinic acid inhibits the activity of cytochrome P450 (CYP450) enzymes

Pharmaceutical Biology, 2020
Context Succinic acid, extracted from amber, is widely used in cardiovascular therapy. Objective The effect of succinic acid on the activity of cytochrome P450 (CYP450) enzymes was investigated in this study.
Hao Wang, Bingyan Xia, Mei Lin, Yongpeng Wang, Bin Sun, Yuzhu Li   +5 more
doaj   +1 more source

Pharmacogenomics of dolutegravir: A scoping review of evidence, gaps and clinical implications

British Journal of Clinical Pharmacology, EarlyView.
Dolutegravir underpins modern first‐ and second‐line HIV treatment regimens; however, interindividual variability in its disposition and tolerability presents challenges for optimal use. This scoping review mapped current evidence on the pharmacogenomics of dolutegravir, focusing on pharmacokinetics and pharmacodynamics, and methodological limitations ...
Ronald Kiguba, Mishael Ssesanga, Munir Pirmohamed   +2 more
wiley   +1 more source

Long‐acting cabotegravir and rilpivirine in people with HIV receiving chronic anticoagulation: A real‐world case series

British Journal of Clinical Pharmacology, EarlyView.
Background Long‐acting intramuscular cabotegravir plus rilpivirine (LA‐CAB + RPV) is an effective maintenance antiretroviral regimen for virologically suppressed people with HIV. However, its use in individuals receiving chronic anticoagulation is limited by concerns regarding intramuscular bleeding risk, and real‐world data are scarce.
Montserrat Laguno, Berta Torres, Maria Martínez‐Rebollar, Paula Arreba, Octavi Roman, Roger LLobet, Leire Berrocal, Alberto Foncillas, Júlia Calvo, Abiu Sempere, Ivan Chivite, Elisa de Lazzari, Josep Mallolas, Ana González‐Cordón   +13 more
wiley   +1 more source

CYP3A4 isoenzyme phenotyping for personalisation of pharmacotherapy

Регуляторные исследования и экспертиза лекарственных средств, 2018
The article reviews existing methods of determining CYP3A4 isoenzyme activity. The authors assess the significance of CYP3A4 activity determination and the applicability of these methods in clinical practice to adjust drugs doses and minimize risks of ...
E. A. Egorenkov, V. V. Smirnov, V. N. Kuzina, S. P. Dementiev, G. V. Ramenskaya   +4 more
doaj  

Association of CYP3A4*1B, CYP3A4*22 and CYP3A5*3 polymorphisms carriage with efficacy and safety of tamsulosin in patients with benign prostatic hyperplasia

Фармация и фармакология (Пятигорск)
Tamsulosin is a first-line drug in the treatment of lower urinary tract symptoms (LUTS) in benign prostatic hyperplasia (BPH). Despite high estimates of its efficacy and safety, it rates may vary due to genetic polymorphisms of genes for the enzymes ...
Sh. P. Abdullaev, M. N. Shatokhin, O. L. Sigailo, Sh. P. Abdullaev, P. O. Bochkov, S. N. Tuchkova, O. V. Teodorovich, O. B. Loran, D. A. Sychev   +8 more
doaj   +1 more source

Pharmacokinetic Assessment of Atazanavir and Favipiravir Following Echinacea Supplementation: A Controlled Herb–Drug Interaction Investigation

Biopharmaceutics &Drug Disposition, EarlyView.
Pharmacokinetic interactions between Echinacea and two antiviral drugs, favipiravir and atazanavir, were assessed in rats. The findings suggest that Echinacea does not significantly affect the pharmacokinetics of favipiravir and atazanavir. These results provide preliminary evidence that concurrent use of Echinacea with these antiviral drugs may be ...
Siva Nageswara Rao Gajula, Jeevan Sai Kallam, Aarika Kanukolanu, Ganesh Korada, Lakshmi Vineela Nalla   +4 more
wiley   +1 more source

Effect of low and high-dose dexamethasone on cyp3a and p-glycoprotein expression and function in mice [PDF]

Eurasian Journal of Veterinary Sciences
Dexamethasone, which acts on nuclear receptors, is used together with P-gp and Cyp3a4 substrates at different doses in the treatment of diverse diseases.
Hatice Eser-Faki, Gonca Sonmez, Bunyamin Tras, Kamil Uney, Tugba Melike Parlak, Zeynep Ozdemir-Kutahya, Hakan Akbayrak   +6 more
doaj  

Interaction between CYP3A4 gene polymorphism and obesity on breast cancer susceptibility in Chinese women

Environmental Health and Preventive Medicine
Background: To date, results on relationship between CYP3A4 gene polymorphism were limited and inconclusive, and no study focused on the influence of CYP3A4 gene-obesity interaction on breast cancer risk, especially in Chinese women.
Jiamin Zhu, Xiaogang Zhai, Feng Ni, Cheng Tan, Yun Guan, Baixia Yang, Jing Cai   +6 more
doaj   +1 more source