Results 91 to 100 of about 56,913 (295)

Effects of glycyrrhizin on the pharmacokinetics of nobiletin in rats and its potential mechanism

Pharmaceutical Biology, 2020
Context Both nobiletin (NBL) and glycyrrhizin (GL) have anti-inflammatory and antitumor properties. These agents may be co-administered in the clinic. However, the drug–drug interaction between them is not clear.
Hao Wang, Lin Dong, Fangfei Qu, Huimin He, Wei Sun, Yuqing Man, Hongjie Jiang   +6 more
doaj   +1 more source

Importance of the identification of the CYP3A4*2 polymorphism for the prescription of pharmacological treatment [PDF]

, 2019
The CYP3A4*2 polymorphism is rare in the population studied. Given the low frequency of CYP3A4*2 polymorphisms found in homozygous or heterozygous condition, it is advisable to consider the genotype of the patient before prescribing drugs metabolized by ...
Montenegro Morales, Laura Patricia;x1340620, Hernández Serrano, Maricela, MEJIA SANCHEZ, FERNANDO; 506806, MEJIA SANCHEZ, FERNANDO, CASTILLO CADENA, JULIETA, De La Cruz, Angelica, Hernández Serrano, Maricela;x1349783, Montenegro Morales, Laura Patricia, De La Cruz, Angelica;#, CASTILLO CADENA, JULIETA; 202796   +9 more
core  

Data_Sheet_1_The Modulatory Role of CYP3A4 in Dictamnine-Induced Hepatotoxicity.docx

, 2018
Dictamni Cortex (DC) has been reported to be associated with acute hepatitis in clinic and may lead to a selective sub-chronic hepatotoxicity in rats. Nevertheless, the potent toxic ingredient and the underlying mechanism remain unknown. Dictamnine (DTN),
Zi-Qi Shi (5767769), Hui-Jun Li (1480486), Ling-Li Wang (4455067), Zhuo-Qing Li (4455073), Li-Long Jiang (4455070), Zi-Tian Wu (5621090), Dong-Sheng Zhao (400721), Jing Zhou (168494), Xian Zheng (5767766), Ping Li (31981)   +9 more
core   +1 more source

Succinic acid inhibits the activity of cytochrome P450 (CYP450) enzymes

Pharmaceutical Biology, 2020
Context Succinic acid, extracted from amber, is widely used in cardiovascular therapy. Objective The effect of succinic acid on the activity of cytochrome P450 (CYP450) enzymes was investigated in this study.
Hao Wang, Bingyan Xia, Mei Lin, Yongpeng Wang, Bin Sun, Yuzhu Li   +5 more
doaj   +1 more source

The CYP3A4 intron 6 C>T polymorphism (CYP3A4*22) is associated with reduced CYP3A4 protein level and function in human liver microsomes [PDF]

Effects of the CYP3A4 intron 6 C>T (CYP3A4*22) polymorphism, which has recently been reported to have a critical role in vivo, were investigated by measuring CYP3A4 protein expression levels and CYP3A4-dependent drug oxidation activities in individual ...
90409384, 45468, Shimada, Tsutomu, 45467, Guengerich, F. Peter, 45466, 1590, Shimizu, Makiko, Yamazaki, Hiroshi, Murayama, Norie, 1575, 90219949, 458, 90307075, Okubo, Maho, 30191274   +15 more
core  

Cyp3a4-Mediated in vitro Metabolism and in vivo Disposition of Lorlatinib in Rats [PDF]

Cong Xie,1,2,* Tongshu Guan,1,2,* Jin Huang,1,2 Jiayu Chen,1,2 Yilei Li,1,2 Ping Zheng1,2 1Clinical Pharmacy Center, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China; 2Department of Pharmacy, Nanfang ...
Li Y, Huang J, Chen J, Guan T, Zheng P, Xie C   +5 more
core  

The Effect of Dicloxacillin Administration on Pharmacokinetics of Narrow Therapeutic Window Drugs: Phenytoin and Warfarin

Clinical Pharmacology &Therapeutics, EarlyView.
Dicloxacillin is a penicillinase‐resistant beta‐lactam antibiotic and potent activator of the Pregnane X receptor (PXR), known to induce CYP2C9, CYP2C19, and CYP3A4 activity. Clinical data suggest it reduces anticoagulation in warfarin‐treated patients and increases the risk of thromboembolic events.
Chanan Shaul, Waseem Mujahed, Ibrahim Idries, Maor Wanounou, Meir Bialer, Yoseph Caraco   +5 more
wiley   +1 more source

Association of CYP3A4*1B, CYP3A4*22 and CYP3A5*3 polymorphisms carriage with efficacy and safety of tamsulosin in patients with benign prostatic hyperplasia

Фармация и фармакология (Пятигорск)
Tamsulosin is a first-line drug in the treatment of lower urinary tract symptoms (LUTS) in benign prostatic hyperplasia (BPH). Despite high estimates of its efficacy and safety, it rates may vary due to genetic polymorphisms of genes for the enzymes ...
Sh. P. Abdullaev, M. N. Shatokhin, O. L. Sigailo, Sh. P. Abdullaev, P. O. Bochkov, S. N. Tuchkova, O. V. Teodorovich, O. B. Loran, D. A. Sychev   +8 more
doaj   +1 more source

Effect of CYP3A4 Methylation on Tacrolimus Pharmacokinetics

Therapeutic Drug Monitoring
Background: Common genetic variants in CYP3A4 together only explain a limited amount of the variability in tacrolimus clearance. This cross-sectional study aimed to explore the extent to which pharmacokinetic variability can be explained by ...
Koudijs, K.K.M., Etsouli, O., Vallerga, C.L., Moes, D.J.A.R., Ruijter, B.N., Swen, J.J., Coenraad, M.J., Gelder, T. van   +7 more
openaire   +4 more sources

Time‐Dependent Bias and Prognostic Confounding in Exposure–Response Analysis of Targeted Therapies: Lessons from Sunitinib in Metastatic Renal Cancer

Clinical Pharmacology &Therapeutics, EarlyView.
Exposure–response (E–R) analyses of sunitinib in metastatic renal cell carcinoma (mRCC) have supported concentration‐guided dose escalation. However, such analyses may be biased when exposure metrics incorporate post‐baseline dose modifications, time‐varying apparent clearance, or baseline factors that influence both pharmacokinetics and clinical ...
Han Liu, Lena E. Friberg
wiley   +1 more source