Results 101 to 110 of about 56,913 (295)

Interaction between CYP3A4 gene polymorphism and obesity on breast cancer susceptibility in Chinese women

Environmental Health and Preventive Medicine
Background: To date, results on relationship between CYP3A4 gene polymorphism were limited and inconclusive, and no study focused on the influence of CYP3A4 gene-obesity interaction on breast cancer risk, especially in Chinese women.
Jiamin Zhu, Xiaogang Zhai, Feng Ni, Cheng Tan, Yun Guan, Baixia Yang, Jing Cai   +6 more
doaj   +1 more source

Effects of psoralen on the pharmacokinetics of anastrozole in rats

Pharmaceutical Biology, 2018
Context: Psoralen and anastrozole are always used together for breast cancer patients in Chinese clinics. Objective: This study investigates the effects of psoralen on the pharmacokinetics of anastrozole in rats and its potential mechanism. Materials and
Yuzhu Zhang, Jingjing Wu, Yue Zhou, Yulian Yin, Hongfeng Chen   +4 more
doaj   +1 more source

CYP3A4 and MDR1 alleles in a Portuguese population

, 2003
Polymorphisms in cytochrome P450 CYP3A4 and multidrug resistance (MDR) 1 genes coding for the important drug-metabolising CYP3A4 and the ATP-binding cassette (ABC) transporter P-glycoprotein (Pgp) are poorly documented in the Portuguese population.
Ribeiro, V, Cavaco, I,, Gil, JP, Gil-Berglund, E   +3 more
core   +1 more source

Dispensing of actionable pharmacogenetic drugs among adults receiving cardiovascular disease medications in the Northern Netherlands: A serial cross‐sectional study

Clinical Pharmacology &Therapeutics, EarlyView.
The extent of pharmacogenetic (PGx) drug dispensing among Dutch adults receiving medications for cardiovascular disease (CVD) is unknown. Using the University of Groningen IADB.nl pharmacy database, we performed a serial cross‐sectional study (2019–2023) to estimate the annual prevalence of PGx drug dispensing and annual rates of initiation.
Zhuolin Zhang, Guiling Zhou, Jens H. J. Bos, Eelko Hak, Talitha Feenstra, Frank Klont   +5 more
wiley   +1 more source

CYP3A4 isoenzyme phenotyping for personalisation of pharmacotherapy

Регуляторные исследования и экспертиза лекарственных средств, 2018
The article reviews existing methods of determining CYP3A4 isoenzyme activity. The authors assess the significance of CYP3A4 activity determination and the applicability of these methods in clinical practice to adjust drugs doses and minimize risks of ...
E. A. Egorenkov, V. V. Smirnov, V. N. Kuzina, S. P. Dementiev, G. V. Ramenskaya   +4 more
doaj  

CYP3A4*1G gene Polymorphism on Javanese People

, 2015
AbtractMost of drugs are metabolized by cytochrome P 450 (CYP) enzyme. Cytochrome P450 3A4 is the cytochrome that is involved in metabolizing more than 60% of all medicine used in human.
Iwan Dwiprahasto, Erna Kristin, Em Sutrisna, Indwiani Astuti   +3 more
core  

Exposure–Response Analysis of Enfortumab Vedotin Plus Pembrolizumab as First‐Line Therapy for Locally Advanced or Metastatic Urothelial Cancer

Clinical Pharmacology &Therapeutics, EarlyView.
Enfortumab vedotin is a nectin‐4‐directed antibody–drug conjugate currently approved in combination with pembrolizumab for the first‐line treatment of locally advanced or metastatic urothelial cancer. Here we describe the exposure–response relationship between enfortumab vedotin exposures and efficacy/safety endpoints in patients who received ≥1 dose ...
Vaishali L. Chudasama, Helen Kastrissios, Hossam Kadry, Daping Zhang, Salaheldin Hamed, Srinivasu Poondru, Souvik Bhattacharya, Russ Wada, Amit Garg, Yen Lin Chia   +9 more
wiley   +1 more source

Effect of low and high-dose dexamethasone on cyp3a and p-glycoprotein expression and function in mice [PDF]

Eurasian Journal of Veterinary Sciences
Dexamethasone, which acts on nuclear receptors, is used together with P-gp and Cyp3a4 substrates at different doses in the treatment of diverse diseases.
Hatice Eser-Faki, Gonca Sonmez, Bunyamin Tras, Kamil Uney, Tugba Melike Parlak, Zeynep Ozdemir-Kutahya, Hakan Akbayrak   +6 more
doaj  

Creatinine–Cystatin C Discrepancy and Renal Transporter Polymorphisms in Japanese Patients with Breast Cancer Receiving Abemaciclib

Clinical Pharmacology &Therapeutics, EarlyView.
Abemaciclib increases serum creatinine by inhibiting renal tubular transporters rather than reducing true glomerular filtration rate, a phenomenon known as pseudo‐acute kidney injury. Creatinine–cystatin C discrepancy and genetic determinants of this elevation remain insufficiently characterized in Japanese patients.
Hiroaki Watanabe, Keita Hirai, Takaaki Oba, Mayu Ono, Ken‐ichi Ito, Takafumi Naito   +5 more
wiley   +1 more source

No association of a set of candidate genes on haloperidol side effects [PDF]

, 2012
We previously investigated a sample of patients during an active phase of psychosis in the search for genetic predictors of haloperidol induced side effects.
Alessandro Serretti, Ro Serretti, Hans-Jürgen Möller (127187), Annette M. Hartmann (127183), Hans H. Stassen (127195), Drago, Antonio, Möller, Hans-Jürgen, Alessandro Serretti (127197), Hartmann, Annette M, Ina Giegling (127175), Giegling, Ina, De Ronchi, Diana, Dan Rujescu, Stassen, Hans H, Ina Giegling, Martin Schäfer, Martin Schäfer (127178), Hans H Stassen, Hartmann, Annette M., Annette M Hartmann, Annette M. Hartmann, Dan Rujescu (109427), Stassen, Hans H., Schäfer, Martin, Diana De Ronchi (127190), Antonio Drago (127172), Serretti, Alessandro, Diana De Ronchi, Hans-Jürgen Möller, Hans H. Stassen, Rujescu, Dan, Antonio Drago, Rujescu Dan, Schäfer Martin, Giegling Ina, De Ronchi Diana, Serretti Alessandro, Stassen Hans H., Hartmann Annette M., Drago Antonio, Möller Hans-Jürgen   +40 more
core   +2 more sources