Results 101 to 110 of about 76,948 (211)

Effects of astragaloside IV on the pharmacokinetics of omeprazole in rats

Pharmaceutical Biology, 2019
Context: Omeprazole and astragaloside IV (AS-IV) are widely used for the treatment of gastric ulcers in China clinics. Objective: This study investigates the effects of AS-IV on the pharmacokinetics of omeprazole in rats.
Wei Liu, Guozhi Liu, Jing Liu
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Rhabdomyolysis Induced by the Interaction Between Ribociclib and Statins- Case Report and Literature Review

Breast Cancer: Targets and Therapy, 2023
Omar Badran,1 Mahmoud Abu Amna,1,2 Ilit Turgeman,1 Gil Bar-Sela1,2 1Department of Oncology, Emek Medical Center, Afula, Israel; 2Technion Integrated Cancer Center, Faculty of Medicine, Technion, Haifa, IsraelCorrespondence: Gil Bar-Sela, Oncology ...
Badran O, Abu Amna M, Turgeman I, Bar-Sela G   +3 more
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Effects of Ginkgo leaf tablets on the pharmacokinetics of losartan and its metabolite EXP3174 in rats and its mechanism

Pharmaceutical Biology, 2018
Context: Ginkgo leaf tablets (GLTs) and losartan are often simultaneously used for the treatment of hypertension in Chinese clinics. However, the herb–drug interaction between GLT and losartan is still unknown.
Baiping Dong, Suowei Yuan, Jinsheng Hu, Yanzhen Yan   +3 more
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Decoding the selective chemical modulation of CYP3A4

Nature Communications
Drug-drug interactions associate with concurrent uses of multiple medications. Cytochrome P450 (CYP) 3A4 metabolizes a large portion of marketed drugs. To maintain the efficacy of drugs metabolized by CYP3A4, pan-CYP3A inhibitors such as ritonavir are often co-administered.
Jingheng Wang, Stanley Nithianantham, Sergio C. Chai, Young-Hwan Jung, Lei Yang, Han Wee Ong, Yong Li, Yifan Zhang, Darcie J. Miller, Taosheng Chen   +9 more
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CYP3A4 and CYP3A5 Genes in Cyclophosphamide-treated Chronic Lymphocytic Leukemia Patients: A Pharmacogenetics Study

Frontiers in Bioscience-Scholar
Background: Approximately 75% of drug metabolism in clinical settings is attributed to cytochrome P450 enzymes. This study aimed to assess the effects of the CYP3A4*1B and CYP3A5*3 genetic variations on the clinical results of ...
Heba M. Elmaraghy, Menna Al-Adl, Eman R. Saifeldein, Sahar M. Elashmony, Magdy M. Youssef, Afaf El-Said, Sherif Refaat, Abdallah E. Mohammed   +7 more
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Половые различия в биотрансформации лекарственных средств: значение для проведения клинических исследований лекарственных средств

Фармакокинетика и Фармакодинамика, 2020
Долгое время клинические исследования лекарственных средств I и II фазы у женщин не проводились, что было связано с опасениями негативного воздействия на возможную беременность и плод.

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CYP3A4 Gene [PDF]

, 2020
openaire   +1 more source

CYP3A4 Substrate [PDF]

, 2020
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CYP3A4 Inhibitor [PDF]

, 2020
openaire   +1 more source

CYP3A4 isoenzyme phenotyping for personalisation of pharmacotherapy

Регуляторные исследования и экспертиза лекарственных средств, 2018
The article reviews existing methods of determining CYP3A4 isoenzyme activity. The authors assess the significance of CYP3A4 activity determination and the applicability of these methods in clinical practice to adjust drugs doses and minimize risks of ...
E. A. Egorenkov, V. V. Smirnov, V. N. Kuzina, S. P. Dementiev, G. V. Ramenskaya   +4 more
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