Results 1 to 10 of about 631 (89)

Effects of genetic polymorphism of CYP3A4 and CYP3A5 on analgesic efficacy of postoperative intravenous analgesia with sufentanil in patients after laparoscopic surgery

Di-san junyi daxue xuebao, 2022
Objective To explore the differences of postoperative patient-controlled intravenous analgesia (PCIA) with sufentanil in the patients with different CYP3A4 and CYP3A5 genotypes after laparoscopic surgery. Methods According to CYP3A4 and CYP3A5 genotypes,
GU Li, ZHOU Li, LI Yongshuai, FENG Liyuan, CHEN Xingtong   +4 more
doaj   +1 more source

Antisense oligonucleotide development for the selective modulation of CYP3A5 in renal disease

Scientific Reports, 2021
CYP3A5 is the primary CYP3A subfamily enzyme expressed in the human kidney and its aberrant expression may contribute to a broad spectrum of renal disorders.
Kevin A. Lidberg, Andrew J. Annalora, Marija Jozic, Daniel J. Elson, Lu Wang, Theo K. Bammler, Susanne Ramm, Maria Beatriz Monteiro, Jonathan Himmelfarb, Craig B. Marcus, Patrick L. Iversen, Edward J. Kelly   +11 more
doaj   +1 more source

Individualized treatment based on single-nucleotide polymorphisms with tacrolimus in ulcerative colitis [PDF]

Intestinal Research, 2019
Background/Aims The pharmacokinetics of tacrolimus (TAC) is known to be largely influenced by single-nucleotide polymorphisms (SNPs) in CYP3A5. Patients starting TAC require careful dose adjustment, owing to the wide range of optimal dosages, depending ...
Shinji Okabayashi, Taku Kobayashi, Eiko Saito, Takahiko Toyonaga, Ryo Ozaki, Shintaro Sagami, Masaru Nakano, Junichi Tanaka, Keiji Yagisawa, Satoshi Kuronuma, Osamu Takeuchi, Toshifumi Hibi   +11 more
doaj   +1 more source

Interaction between Darunavir and Etravirine Is Partly Mediated by CYP3A5 Polymorphism. [PDF]

PLoS ONE, 2016
To assess the impact of the loss-of-function CYP3A5*3 allele (rs776746, 6986A>G SNP) on darunavir (DRV) plasma concentrations.135 HIV-1 infected patients treated with DRV-based therapy were included in the study and plasma samples were obtained ...
Leïla Belkhir, Laure Elens, Francis Zech, Nadtha Panin, Anne Vincent, Jean Cyr Yombi, Bernard Vandercam, Vincent Haufroid   +7 more
doaj   +1 more source

Effect of cytochrome P450 3A5 polymorphism on the pharmacokinetics of tacrolimus in renal transplant recipients

Korean Journal of Transplantation, 2020
Background : Renal transplant is an effective treatment option for end-stage kidney disease and tacrolimus is one of the most commonly used immunosuppressant drugs in renal transplant patients.
Yi Yi Htun, Nwe Nwe Than, Htar Kyi Swe
doaj   +1 more source

Alleles of CYP3A5 and their association with renal function in chronic kidney disease [PDF]

PeerJ
Background The cytochrome P450 family 3 subfamily A polypeptide 5 (CYP3A5) gene plays an important role in renal function through its product’s involvement in metabolizing endogenous substances and drugs, including immunosuppressants used following ...
Onnapa Kongphan, Worachart Lert-itthiporn, Ubon Cha’on, Sirirat Anutrakulchai, Kanokwan Nahok, Nadthanicha Artkaew, Chanpen Sriphan, Apinya Jusakul   +7 more
doaj   +2 more sources

CYP3A5 Genotype-Dependent Drug-Drug Interaction Between Tacrolimus and Nifedipine in Chinese Renal Transplant Patients

Frontiers in Pharmacology, 2021
Purpose: The drug-drug interactions (DDIs) of tacrolimus greatly contributed to pharmacokinetic variability. Nifedipine, frequently prescribed for hypertension, is a competitive CYP3A5 inhibitor which can inhibit tacrolimus metabolism.
Yilei Yang, Xin Huang, Yinping Shi, Rui Yang, Haiyan Shi, Xinmei Yang, Guoxiang Hao, Yi Zheng, Jianning Wang, Lequn Su, Yan Li, Wei Zhao, Wei Zhao   +12 more
doaj   +1 more source

Association of CYP3A5 polymorphisms and parathyroid hormone with blood level of tacrolimus in patients with end‐stage renal disease

Clinical and Translational Science, 2021
Because tacrolimus is predominantly metabolized by CYP3A, the blood concentration/dose (C/D) ratio is affected by CYP3A5 polymorphism. Parathyroid hormone (PTH) expression increases in secondary hyperparathyroidism, which is frequently associated with ...
Ryota Tanaka, Yosuke Suzuki, Hiroshi Watanabe, Takashi Fujioka, Kenshiro Hirata, Toshitaka Shin, Tadasuke Ando, Hiroyuki Ono, Ryosuke Tatsuta, Hiromitsu Mimata, Toru Maruyama, Hiroki Itoh   +11 more
doaj   +1 more source

The effect of rs776746 polymorphism in the CYP3A5 gene on heart rate when using bisoprolol in patients with acute coronary syndrome

Рациональная фармакотерапия в кардиологии, 2022
Aim. The aim of this work was to study the occurrence of the rs776746 allelic variant of the CYP3A5 gene and its effect on heart rate (HR) when using bisoprolol in patients hospitalized with acute coronary syndrome (ACS).Materials and methods.
V. A. Shumkov, K. A. Zagorodnikova, S. A. Boldueva, A. A. Murzina   +3 more
doaj   +1 more source

Comparison of Steroid Hormone Hydroxylations by and Docking to Human Cytochromes P450 3A4 and 3A5

Journal of Pharmacy & Pharmaceutical Sciences, 2019
Purpose: Hydroxylation activity at the 6β-position of steroid hormones (testosterone, progesterone, and cortisol) by human cytochromes P450 (P450 or CYP) 3A4 and CYP3A5 and their molecular docking energy values were compared to understand the catalytic ...
Toshiro Niwa, Kanae Narita, Ayaka Okamoto, Norie Murayama, Hiroshi Yamazaki   +4 more
doaj   +1 more source