Results 11 to 20 of about 15,566 (231)

Genotyping of the A6986G polymorphism of CYP3A5 [PDF]

British Journal of Clinical Pharmacology, 2003
We read with great interest the article in the June 2003 issue of the British Journal of Clinical Pharmacology by King and coworkers which reports the CYP3A5 phenotype-genotype correlation in a British population [1]. Whereas the interpretation of the data and the conclusions are correct, we believe that there are some discrepancies concerning the ...
Johanna, Weiss, Walter E, Haefeli
openaire   +2 more sources

CYP3A5 polymorphism, amlodipine and hypertension [PDF]

Journal of Human Hypertension, 2013
As a major cardiovascular risk factor for stroke, coronary artery disease, heart failure and end-stage renal disease, hypertension affects approximately one billion people and causes large economic burden worldwide. Cytochrome P450 3A5 (CYP3A5), belonging to the CYP3A subfamily, has been implicated in the regulation of blood pressure and may serve as a
Y-P, Zhang, X-C, Zuo, Z-J, Huang, J-J, Cai, J, Wen, D D, Duan, H, Yuan   +6 more
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Association of the CYP3A5 A6986G (CYP3A5*3) polymorphism with saquinavir pharmacokinetics [PDF]

British Journal of Clinical Pharmacology, 2004
Saquinavir is a selective HIV protease inhibitor with limited systemic bioavailability (4% for the hard gelatin capsule (Invirase®), and about 12% for the soft gelatin capsule (Fortovase®) [1]) as a result of extensive phase I metabolism by CYP3A in the gut and liver.
Fröhlich, Margret, Hoffmann, Michael M., Burhenne, Jürgen, Mikus, Gerd, Weiss, Johanna, Haefeli, Walter Emil   +5 more
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CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

CYP3A4 and CYP3A5genotyping by Pyrosequencing [PDF]

BMC Medical Genetics, 2005
Human cytochrome P450 3A enzymes, particularly CYP3A4 and CYP3A5, play an important role in drug metabolism. CYP3A expression exhibits substantial interindividual variation, much of which may result from genetic variation. This study describes Pyrosequencing assays for key SNPs in CYP3A4 (CYP3A4*1B, CYP3A4*2, and CYP3A4*3) and CYP3A5 (CYP3A5*3C and ...
McLeod Howard L, Garsa Adam A, Marsh Sharon   +2 more
openaire   +3 more sources

Association of CYP3A5 polymorphisms and parathyroid hormone with blood level of tacrolimus in patients with end‐stage renal disease

Clinical and Translational Science, 2021
Because tacrolimus is predominantly metabolized by CYP3A, the blood concentration/dose (C/D) ratio is affected by CYP3A5 polymorphism. Parathyroid hormone (PTH) expression increases in secondary hyperparathyroidism, which is frequently associated with ...
Ryota Tanaka, Yosuke Suzuki, Hiroshi Watanabe, Takashi Fujioka, Kenshiro Hirata, Toshitaka Shin, Tadasuke Ando, Hiroyuki Ono, Ryosuke Tatsuta, Hiromitsu Mimata, Toru Maruyama, Hiroki Itoh   +11 more
doaj   +1 more source

The effect of rs776746 polymorphism in the CYP3A5 gene on heart rate when using bisoprolol in patients with acute coronary syndrome

Рациональная фармакотерапия в кардиологии, 2022
Aim. The aim of this work was to study the occurrence of the rs776746 allelic variant of the CYP3A5 gene and its effect on heart rate (HR) when using bisoprolol in patients hospitalized with acute coronary syndrome (ACS).Materials and methods.
V. A. Shumkov, K. A. Zagorodnikova, S. A. Boldueva, A. A. Murzina   +3 more
doaj   +1 more source

Comparison of Steroid Hormone Hydroxylations by and Docking to Human Cytochromes P450 3A4 and 3A5

Journal of Pharmacy & Pharmaceutical Sciences, 2019
Purpose: Hydroxylation activity at the 6β-position of steroid hormones (testosterone, progesterone, and cortisol) by human cytochromes P450 (P450 or CYP) 3A4 and CYP3A5 and their molecular docking energy values were compared to understand the catalytic ...
Toshiro Niwa, Kanae Narita, Ayaka Okamoto, Norie Murayama, Hiroshi Yamazaki   +4 more
doaj   +1 more source

Xenobiotic metabolism: the effect of acute kidney injury on non-renal drug clearance and hepatic drug metabolism. [PDF]

, 2014
Acute kidney injury (AKI) is a common complication of critical illness, and evidence is emerging that suggests AKI disrupts the function of other organs.
Abosaif, Andres-Hernando, Andres-Hernando, Barbara Philips, Boucher, Bougle, Brown, Chan, Chawla, Chung, Doi, Dowling, Dreisbach, Dreisbach, English, Fadillioglu, Gardiner, Gertz, Golab, Group, Gurley, Hassoun, Heinemeyer, Heinemeyer, Iain MacPhee, Izuwa, John Dixon, Karim, Katie Lane, Kirwan, Kirwan, Klein, Kramer, Krueger, Kunihara, Kunuzova, Lane, Lash, Leblanc, Lee, Lee, Lohr, Martyn, Mastorakos, Meier-Hellmann, Michaud, Michaud, Miyazawa, Muntane-Relat, Murakami, Naud, Naud, Nicholson, Nolin, Nolin, Okabe, Okabe, Okabe, Owen, O’Shaunessy, Park, Park, Philips, Power, Schneider, Serteser, Shi, Shibata, Smith, Soni, Spapen, Srinivas, Sun, Tanabe, Tian, Venkatesh, Wang, Whelton, Wilkinson, Wilson, Yamaguchi, Yoshitani, Yu   +82 more
core   +2 more sources

The genetic determinants of the CYP3A5 polymorphism

Pharmacogenetics, 2001
CYP3A proteins comprise a significant portion of the hepatic cytochrome P450 (CYP) protein and they metabolize around 50% of drugs currently in use. The dissection of the individual contributions of the four CYP3A genes identified in humans to overall hepatic CYP3A activity has been hampered by sequence and functional similarities. We have investigated
Hustert, E., Haberl, M., Burk, O., Wolbold, R., He, Y. Q., Klein, K., Nuessler, A. C., Neuhaus, P., Klattig, J., Eiselt, R., Koch, I., Zibat, Arne, Brockmoeller, Juergen, Halpert, J. R., Zanger, Ulrich M., Wojnowski, Leszek   +15 more
openaire   +3 more sources