Results 21 to 30 of about 15,566 (231)
Pharmaceutics, 2022 There is a large variability in individual responses to atorvastatin administration. This study assessed the pharmacogenetic effects of solute carrier organic anion transporter family member 1B1 (SLCO1B1, c.388A>G and c.521T>C) and cytochrome P450 3A5 ...
Jin-Woo Park +5 more
doaj +1 more source
Individualized immunosuppression in transplant patients: potential role of pharmacogenetics. [PDF]
, 2012 The immunosuppressive drugs used to prevent the rejection of transplanted organs have a narrow therapeutic index. Under treatment results in episodes of rejection leading to either damage or loss of the organ. Over immunosuppression increases the risk of
Abboudi, H, Macphee, IA
core +2 more sources
Pharmacokinetics and Pharmacogenetics of Apixaban
Рациональная фармакотерапия в кардиологии, 2020 Apixaban is oral anticoagulant, it is widely used in prevention of stroke in non-valvular atrial fibrillation and treatment of deep vein thrombosis and pulmonary embolism. Its main mechanism of action is through reversible inhibition of factor Xa.
A. V. Savinova +4 more
doaj +1 more source
Decreased expression of cytochrome P450 protein in non-malignant colonic tissue of patients with colonic adenoma [PDF]
, 2005 Background Cytochrome P450 (CYP) enzymes in epithelial cells lining the alimentary tract play an important role in both the elimination and activation of (pro-)carcinogens.
Ina Bergheim +29 more
core +1 more source
Journal of Pharmacy & Pharmaceutical Sciences, 2013 Purpose: To determine the effects of CYP3A5 polymorphisms on carbamazepine (CBZ) pharmacokinetic parameters when CBZ is used either as monotherapy or co-administered with phenytoin (PHT), phenobarbital (PB) or valproic acid (VPA).
Duangchit Panomvana +2 more
doaj +1 more source
Profile of once-daily zonisamide as monotherapy for treatment of partial seizures in adults. [PDF]
, 2013 Epilepsy is one of the most common neurologic disorders, affecting about 50 million people around the world. It is recognized that around 50% of patients with newly diagnosed epilepsy become seizure-free with the first drug treatment, so the choice of ...
Mula, M
core +3 more sources
PLoS ONE, 2014 The influence of self-reported "race/color", geographical origin and genetic ancestry on the distribution of three functional CYP3A5 polymorphisms, their imputed haplotypes and inferred phenotypes was examined in 909 healthy, adult Brazilians, self ...
Guilherme Suarez-Kurtz +8 more
doaj +1 more source
Contribution of CYP3A5 to the in Vitro Hepatic Clearance of Tacrolimus [PDF]
Clinical Chemistry, 2005 Abstract Background: Tacrolimus is metabolized predominantly to 13-O-demethyltacrolimus in the liver and intestine by cytochrome P450 3A (CYP3A). Patients with high concentrations of CYP3A5, a CYP3A isoenzyme polymorphically produced in these organs, require higher doses of tacrolimus, but the exact mechanism of this association is ...
Kamdem, L. K. +6 more
openaire +3 more sources
A Method to Exchange Recombinant Differentially Phosphorylated Rhodamine-Labeled Cardiac RLC into Permeabilized Cardiac Trabeculae [PDF]
, 2012 Cyclosporine, everolimus, and tacrolimus are the cornerstone of immunosuppressive therapy in renal transplantation. These drugs are characterized by narrow therapeutic windows, highly variable pharmacokinetics (PK), and metabolism by CYP3A enzymes ...
Bemelman, F J +8 more
core +1 more source
Рациональная фармакотерапия в кардиологии, 2018 The considered clinical case of combination of multifocal atherosclerotic vascular lesion with type 2 diabetes mellitus and liver fibrosis demonstrates a combination of polyvalent risk factors for resistance to antiplatelet therapy with clopidogrel. The
M. A. Andreyanova +5 more
doaj +1 more source