Results 31 to 40 of about 15,566 (231)

Population Pharmacokinetics of Tacrolimus in Adult Kidney Transplant Patients: Impact of CYP3A5 Genotype on Starting Dose. [PDF]

, 2013
Objectives: The aims of this study were to develop a population pharmacokinetic model of tacrolimus in adult kidney transplant recipients, to use this model to compare cytochrome P450 3A5 (CYP3A5) genotype-based initial dosing of tacrolimus with standard
Anderson, Antignac, Antignac, Barraclough, Barraclough, Barraclough, Benkali, Bergstrand, Elens, Fukatsu, Garcia Sanchez, Hennig, Hesselink, Jonsson, Keevil, Keizer, Lindbom, McLeay, McWhinney, Opelz, Press, Proost, Saint-Marcoux, Sam, Scholten, Staatz, Staatz, Thervet, Thomson, Velickovic-Radovanovic, Wallemacq, Wallin, Woillard, Zhang, Zhao   +34 more
core   +1 more source

Effect of polymorphisms in CYP3A4*22 (rs35599367) C>T, CYP3A5*3 (rs776746) A>G, ABCB1 (rs4148738) C>T and ABCB1 (rs1045642) C>T genes on apixaban anticoagulation: pilot study results

Медицинский совет, 2021
Introduction. Apixaban is a direct oral anticoagulant prescribed for treatment and prevention of venous thromboembolism (VTE) and for prevention of stroke in patients with nonvalvular atrial fibrillation.
I. N. Sychev, L. V. Fedina, A. S. Osipov, I. I. Temirbulatov, O. Yu. Tataroy, Zh. A. Sozaeva, K. A. Akmalova, N. P. Denisenko, S. P. Abdullaev, A. A. Kachanova, E. A. Grishina, K. B. Mirzaev, D. A. Sychev   +12 more
doaj   +1 more source

Pregnane X receptor and yin yang 1 contribute to the differential tissue expression and induction of CYP3A5 and CYP3A4. [PDF]

PLoS ONE, 2012
The hepato-intestinal induction of the detoxifying enzymes CYP3A4 and CYP3A5 by the xenosensing pregnane X receptor (PXR) constitutes a key adaptive response to oral drugs and dietary xenobiotics.
Dieudonné Nem, Dorothea Baranyai, Huan Qiu, Ute Gödtel-Armbrust, Sebastian Nestler, Leszek Wojnowski   +5 more
doaj   +1 more source

Association of CYP3A4*1B, CYP3A4*22 and CYP3A5*3 polymorphisms carriage with efficacy and safety of tamsulosin in patients with benign prostatic hyperplasia

Фармация и фармакология (Пятигорск)
Tamsulosin is a first-line drug in the treatment of lower urinary tract symptoms (LUTS) in benign prostatic hyperplasia (BPH). Despite high estimates of its efficacy and safety, it rates may vary due to genetic polymorphisms of genes for the enzymes ...
Sh. P. Abdullaev, M. N. Shatokhin, O. L. Sigailo, Sh. P. Abdullaev, P. O. Bochkov, S. N. Tuchkova, O. V. Teodorovich, O. B. Loran, D. A. Sychev   +8 more
doaj   +1 more source

A New CYP3A5 Variant, CYP3A5*11, Is Shown to Be Defective in Nifedipine Metabolism in a Recombinant cDNA Expression System [PDF]

Drug Metabolism and Disposition, 2007
A new CYP3A5 variant, CYP3A5*11, was found in a white European subject by DNA sequencing. The CYP3A5*11 allele contains a single nucleotide polymorphism (SNP) (g.3775A>G) in exon 2, which results in a Tyr53Cys substitution, and a g.6986A>G splice change, the latter SNP previously reported in the defective CYP3A5*3 allele. However, the CYP3A5*3 is not a
Su-Jun, Lee, Ilse P, van der Heiden, Joyce A, Goldstein, Ron H N, van Schaik   +3 more
openaire   +2 more sources

Wuzhi Capsule Dosage Affects Tacrolimus Elimination in Adult Kidney Transplant Recipients, as Determined by a Population Pharmacokinetics Analysis

Pharmacogenomics and Personalized Medicine, 2021
Lizhi Chen,1,* Yunyun Yang,1,2,* Xuebin Wang,1,* Chenyu Wang,2 Weiwei Lin,3 Zheng Jiao,2,4 Zhuo Wang1 1Department of Pharmacy, Shanghai Changhai Hospital, Naval Medical University, Shanghai, 200433, People’s Republic of China; 2Department of ...
Chen L, Yang Y, Wang X, Wang C, Lin W, Jiao Z, Wang Z   +6 more
doaj  

Economic Evaluation of Pharmacogenetic Tests in Patients Subjected to Renal Transplantation: A Review of Literature [PDF]

, 2016
Renal transplantation is the treatment of choice for the patients with end-stage renal failure. Genetic factors, among others, can influence variability in response to immunosuppressive drugs.
Aleksandra Kovacevic, Natasa Djordjevic, Nemanja Rancic, Neven Vavic, Viktorija Dragojevic-Simic, Zoran Segrt   +5 more
core   +2 more sources

Pharmacogenetics of antiretroviral drugs [PDF]

, 2012
nem
Dragović Gordana, Grbović Leposava, Jevtović Đorđe   +2 more
core   +1 more source

Endomyocardial, intralymphocyte, and whole blood concentrations of ciclosporin A in heart transplant recipients [PDF]

, 2013
BACKGROUND: In the early phases following heart transplantation a main challenge is to reduce the impact of acute rejections. Previous studies indicate that intracellular ciclosporin A (CsA) concentration may be a sensitive acute rejection marker in ...
Anders Åsberg, Arne K Andreassen, Hege Christensen, Ida Robertsen, Lars Gullestad, Niclas Lunder, Nina K Næss, Pål Falck   +7 more
core   +1 more source

Metabolic differences in colon mucosal cells [PDF]

, 1993
The colonic expression of cytochromes P450 from the CYP1A, CYP3A and CYP4B subfamilies has been characterized in rabbit and human tissues using RNA blotting, immunoblotting, immunohistochemistry and hybridization histochemistry. These studies demonstrate
Burgess, W. M., Gonzalez, F. J., McKinnon, R. A., McManus, M. E.   +3 more
core   +1 more source