Results 51 to 60 of about 631 (89)

Impact of CYP3A5 1* and 3* single nucleotide variants on tacrolimus pharmacokinetics and graft rejection risk in pediatric kidney transplant patients

Frontiers in Pharmacology
Tacrolimus, a calcineurin inhibitor, is widely used to prevent allograft rejection in kidney transplant recipients. Its metabolism is predominantly mediated by the cytochrome P450 3A5 (CYP3A5) enzyme, and single nucleotide variants (SNVs) within intron 3
Lesly Yanira Xajil-Ramos, Lesly Yanira Xajil-Ramos, Lesly Yanira Xajil-Ramos, Lesly Yanira Xajil-Ramos, Jesús Alonso Gándara-Mireles, Jesús Alonso Gándara-Mireles, Rodrigo José Vargas Rosales, Rodrigo José Vargas Rosales, Rodrigo José Vargas Rosales, Oscar Kevin Sánchez García, Andrea Mariela Ruano Toledo, Amy Kateleen Aldana de la Cruz, Ismael Lares-Asseff, Ismael Lares-Asseff, Leslie Patrón-Romero, Horacio Almanza-Reyes, Randall Lou-Meda   +16 more
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Association of CYP3A5 Gene Polymorphisms and Amlodipine-Induced Peripheral Edema in Chinese Han Patients with Essential Hypertension

Pharmacogenomics and Personalized Medicine, 2021
Hao Liang,1,2,* Xinru Zhang,3,* Zhuo Ma,4,* Yan Sun,1,2 Chang Shu,1 Yihua Zhu,5,6 Yanwei Zhang,6 Songnian Hu,1,2 Xiujuan Fu,3 Lihong Liu4 1State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing ...
Liang H, Zhang X, Ma Z, Sun Y, Shu C, Zhu Y, Zhang Y, Hu S, Fu X, Liu L   +9 more
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CYP3A5 genotyping-guided dosing versus weight-based dosing in a multi-ethnic population of kidney transplant recipients

Proceedings of Singapore Healthcare
Introduction Tacrolimus is the cornerstone of immunosuppression after kidney transplantation (KTx) and is characterized by a narrow therapeutic index and large inter-individual variability.
Rou Wei Lim, Quan Yao Ho, Yan Ting Yeo, Ian Tatt Liew, Carolyn Shan-Yeu Tien, Sobhana Thangaraju, Puay Hoon Lee, Terence Kee   +7 more
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Effects of CYP3A5 Polymorphisms on Efficacy and Safety of Tacrolimus Therapy in Patients with Idiopathic Membranous Nephropathy

Pharmacogenomics and Personalized Medicine, 2020
Chengning Zhang,1,* Suyan Duan,1,* Miao Guo,2 Yanggang Yuan,1 Zhimin Huang,1 Jingfeng Zhu,1 Bin Sun,1 Bo Zhang,1 Changying Xing1 1Departments of Nephrology; 2Department of Pharmacy, The First Affiliated Hospital of Nanjing Medical University, Nanjing ...
Zhang C, Duan S, Guo M, Yuan Y, Huang Z, Zhu J, Sun B, Zhang B, Xing C   +8 more
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CYP3A5 polymorphisms in renal transplant recipients: influence on tacrolimus treatment

Pharmacogenomics and Personalized Medicine, 2018
Lucy Chen,1 G V Ramesh Prasad2 1Kidney Transplant Program, St Michael’s Hospital, Toronto, ON, Canada; 2Division of Nephrology, St Michael’s Hospital, Toronto, ON, Canada Abstract: Tacrolimus is a commonly used immunosuppressant after ...
Chen L, Prasad GV
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Association of CYP3A4 and CYP3A5 polymorphisms with Iranian breast cancer patients

Egyptian Journal of Medical Human Genetics, 2015
Background: Polymorphisms of different gene have been reported to be associated with cancer including breast cancer. Hospitalization rate for breast cancer has increased over the years in Iran.
Elham Badavi, Babak Safavi, Amir Jalali, Ghazaleh Mohammadzadeh Shahriary, Javad Mohammadi-Asl, Javad Babaei   +5 more
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CYP3A4 and CYP3A5 Genes in Cyclophosphamide-treated Chronic Lymphocytic Leukemia Patients: A Pharmacogenetics Study

Frontiers in Bioscience-Scholar
Background: Approximately 75% of drug metabolism in clinical settings is attributed to cytochrome P450 enzymes. This study aimed to assess the effects of the CYP3A4*1B and CYP3A5*3 genetic variations on the clinical results of ...
Heba M. Elmaraghy, Menna Al-Adl, Eman R. Saifeldein, Sahar M. Elashmony, Magdy M. Youssef, Afaf El-Said, Sherif Refaat, Abdallah E. Mohammed   +7 more
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Pharmacogenetics may influence tacrolimus daily dose, but not urinary tubular damage markers in the long-term period after renal transplantation [PDF]

Journal of Medical Biochemistry, 2015
Background: The primary goal of this study was to evaluate the influence of cytochrome P450 (CYP) 3A5 (6986A>G) and ABCB1 (3435C>T) polymorphisms on tacrolimus (TAC) dosage regimen and exposure.
Stefanović Nikola Z., Cvetković Tatjana P., Veličković-Radovanović Radmila M., Jevtović-Stoimenov Tatjana M., Vlahović Predrag M., Stojanović Ivana R., Pavlović Dušica D.   +6 more
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CYP3A5 promotes glioblastoma stemness and chemoresistance through fine-tuning NAD+/NADH ratio

Journal of Experimental & Clinical Cancer Research
Background Glioblastoma multiforme (GBM) exhibits a cellular hierarchy with a subpopulation of stem-like cells known as glioblastoma stem cells (GSCs) that drive tumor growth and contribute to treatment resistance.
Wentao Hu, Xiaoteng Cui, Hongyu Liu, Ze Li, Xu Chen, Qixue Wang, Guolu Zhang, Er Wen, Jinxin Lan, Junyi Chen, Jialin Liu, Chunsheng Kang, Ling Chen   +12 more
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ФАРМАКОГЕНЕТИЧЕСКИЕ АСПЕКТЫ ТЕРАПИИ ТРОМБОЗА УШКА ЛЕВОГО ПРЕДСЕРДИЯ: РЕЗИСТЕНТНОСТЬ К ЛЕЧЕНИЮ ПРЯМЫМИ ПЕРОРАЛЬНЫМИ АНТИКОАГУЛЯНТАМИ У ПАЦИЕНТОВ С ФИБРИЛЛЯЦИЕЙ ПРЕДСЕРДИЙ

Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta
Актуальность. Фибрилляция предсердий (ФП) является самым распространенным нарушением ритма сердца, которое ассоциировано с повышенным риском тромбоэмболических осложнений.
О. В. Будревич, В. А. Снежицкий   +1 more
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