Results 61 to 70 of about 631 (89)

Influence of Cyp3A4, Cyp3A5 and ABCB1 polymorphisms on tacrolimus concentrations and rejection risk in Indian kidney transplant recipients

Indian Journal of Transplantation
Background: Tacrolimus metabolism is known to be determined by gene polymorphisms. Cyp3A5 genotype has most widely been seen to be associated with tacrolimus metabolism. Studies on other genes have produced mixed results.
Kamal Kiran Mukkavilli, Mohammed Shoeb A Khan, Arun Kumar Donakonda, Suma Rama Gopal Gangisetty, Dileena Poojaveli   +4 more
doaj   +1 more source

Optimisation of antihypertensive therapy based on pharmacogenetic data: a clinical case

Рациональная фармакотерапия в кардиологии
In clinical practice, arterial hypertension often shows inadequate blood pressure control despite standard antihypertensive therapy. Genetically determined variability in pharmacokinetics and pharmacodynamics may contribute to interindividual differences
N. B. Cheskidova, M. T. Torobaeva, A. K. Kalmuratova, Y. M. Madyarova, M. T. Duishenalieva, S. S. Abilova, U. K. Kundashev, A. G. Polupanov   +7 more
doaj   +1 more source

Impact of CYP3A4 and CYP3A5 Genetic Variants on Tacrolimus Dosing and Therapeutic Outcomes in Kidney Transplant Recipients

Majalah Kedokteran Bandung
Tacrolimus is the cornerstone of immunosuppressive therapy in kidney transplantation; however, its narrow therapeutic index and variable metabolism make dose optimization difficult.
Hafiza Fareeha Bashir, Rasheeda Bashir, Farheen Aslam, Sana Rafaqat, Amina Latif, Areej Fatima, Zunaira Tahir   +6 more
doaj   +1 more source

Impact of donor CYP3A5 genotype on pharmacokinetics of tacrolimus in South African paediatric liver transplant patients

South African Medical Journal
Background. In the paediatric liver transplant programme in Johannesburg, South Africa (SA), tacrolimus is the calcineurin inhibitor of choice, comprising an essential component of the immunosuppression regimen.
C Wheeler, C Masimirembwa, B Mthembu, J Botha, J Scholefield, J Fabian   +5 more
doaj   +1 more source

Lack of association between genetic variations in CYP3A5 and blood pressure or hypertension risk in the UK biobank

Frontiers in Genetics
IntroductionHypertension (HTN) is a leading risk factor for several cardiovascular diseases. While some previous studies reported that CYP3A5 variants were associated with decreased blood pressure and risk of HTN, others reported no associations ...
Pia Leibold, Christelle Lteif, Julio D. Duarte   +2 more
doaj   +1 more source

Drug-drug interaction between diltiazem and tacrolimus in relation to CYP3A5 genotype status in Chinese pediatric patients with nephrotic range proteinuria: a retrospective study

Frontiers in Pharmacology
BackgroundTacrolimus is widely used to treat pediatric nephrotic range proteinuria (NRP). Diltiazem, a CYP3A4/5 inhibitor, is often administered with tacrolimus, affecting its pharmacokinetic profile. The impact of this combination on tacrolimus exposure,
Qiaoling Yang, Qiaoling Yang, Yan Wang, Yan Wang, Xuebin Wang, Ping Wang, Boyu Tan, Yijun Li, Huajun Sun, Wenyan Huang, Hongxia Liu   +10 more
doaj   +1 more source

Drug–drug interaction between tacrolimus and caspofungin in Chinese kidney transplant patients with different genotypes

Therapeutic Advances in Drug Safety
Background: The effect of drug–drug interaction between tacrolimus and caspofungin on the pharmacokinetics of tacrolimus in different CYP3A5 genotypes has not been reported in previous studies.
Yundi Zhang, Bowen Shen, Yue Li, Huiying Zong, Xiaoming Zhang, Xiaohong Cao, Fengxi Liu, Yan Li   +7 more
doaj   +1 more source

Effect of CYP3A5 genotypes on pharmacokinetic of tacrolimus in colombian liver transplant patients

Frontiers in Pharmacology
BackgroundPrevious studies have reported a reduced tacrolimus dose-adjusted exposure in individuals expressing the CYP3A5*1 allele (rs 776746). However, information regarding Colombian liver transplantation patients is scarce.
Erica Fernanda Lindarte, Erica Fernanda Lindarte, Gonzalo De Jesus Vasquez, Luis Guillermo Toro Rendón, Luis Guillermo Toro Rendón, Andrés Felipe Zuluaga Salazar, Andrés Felipe Zuluaga Salazar, Jefferson Antonio Buendia, Jefferson Antonio Buendia   +8 more
doaj   +1 more source

Pharmacogenomic Analysis of CYP3A5*3 and Tacrolimus Trough Concentrations in Vietnamese Renal Transplant Outcomes

Pharmacogenomics and Personalized Medicine
Thi Van Anh Nguyen,1,* Ba Hai Le,2,* Minh Thanh Nguyen,2,* Viet Thang Le,3,* Viet Tien Tran,4,* Dinh Tuan Le,5,* Duong Anh Minh Vu,2,* Quy Kien Truong,3,* Trong Hieu Le,2,* Huong Thi Lien Nguyen2,* 1Department of ...
Nguyen TVA, Le BH, Nguyen MT, Le VT, Tran VT, Le DT, Vu DAM, Truong QK, Le TH, Nguyen HTL   +9 more
doaj  

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Effect of CYP3A5*3 genotype on serum carbamazepine concentrations at steady-state in Korean epileptic patients

Journal of Clinical Pharmacy and Therapeutics, 2009
J-Y Park
exaly