Results 1 to 10 of about 19,916 (177)

The Effect of Dicloxacillin Administration on Pharmacokinetics of Narrow Therapeutic Window Drugs: Phenytoin and Warfarin. [PDF]

Clin Pharmacol Ther
Dicloxacillin is a penicillinase‐resistant beta‐lactam antibiotic and potent activator of the Pregnane X receptor (PXR), known to induce CYP2C9, CYP2C19, and CYP3A4 activity. Clinical data suggest it reduces anticoagulation in warfarin‐treated patients and increases the risk of thromboembolic events.
Shaul C, Mujahed W, Idries I, Wanounou M, Bialer M, Caraco Y.   +5 more
europepmc   +2 more sources

Phenotypical and functional characterization of a HepG2 cell clone stably overexpressing cytochrome P450 (CYP) 2C9 [PDF]

BMC Research Notes
Objective We aimed to generate a HepG2 cell clone stably overexpressing cytochrome P450 (CYP) 2C9 together with an empty vector (EV) control cell clone for pharmacological and toxicological studies of substances with CYP2C9-mediated biotransformation ...
Sarah Kammerer, Natalie Herzog, Thea Jenchen, Valentina Stock, Rebecca Hofer, Veronika Ruzsanyi, Jan-Heiner Küpper   +6 more
doaj   +2 more sources

Risk of Severe Hypoglycemia Associated With Concomitant Use of Sulfonylureas and Amiodarone. [PDF]

Diabetes Obes Metab
ABSTRACT Aims To evaluate whether initiation of amiodarone while receiving sulfonylurea is associated with an increased risk of severe hypoglycemia compared with the initiation of other antiarrhythmic agents (flecainide, sotalol, or propafenone) while receiving sulfonylurea. Materials and Methods We conducted a population‐based cohort study using South
Bea S, Lee H, Cho YM, Choi YJ, Shin JY, Bykov K.   +5 more
europepmc   +2 more sources

Ruxolitinib Pharmacokinetics and Exposure-Toxicity Relationship in Hematologic Malignancies and Immune-Mediated Diseases: A Prospective Observational Study. [PDF]

Clin Pharmacol Ther
Ruxolitinib pharmacokinetics (PK) has been characterized in clinical trials but remains poorly documented in real‐world practice. This project aimed to investigate ruxolitinib PK in routine clinical practice, identify factors driving its variability, and explore exposure–response relationships to assess the potential role of therapeutic drug monitoring.
Tachet J, Meyer SC, Grandoni F, Haefliger E, Nagy-Hulliger M, Halter JP, Passweg JR, Haefliger D, Bardinet C, Decosterd LA, Guidi M, Girardin FR.   +11 more
europepmc   +2 more sources

Investigation of In Vitro α-Amylase Inhibitory, Antioxidant, Phytochemical Profiling, Molecular Docking, and Swiss ADME Analysis of Magnolia zotictla. [PDF]

Chem Biodivers
Phytochemical profiling was determined via HPLC and GC–MS analysis. In HPLC analysis, five compounds were identified, while five compounds were identified through GC–MS. The plant extract exhibited good antioxidant efficacy in the DPPH assay, highlighting its capacity to neutralize free radicals. The extract has IC5₀ value of 123.8 µg/mL, while that of
Zahoor M, Shah U, Bibi M, Khan A, Haseena, Alotaibi A.   +5 more
europepmc   +2 more sources

Evaluation of the Effect of Cendakimab on the Pharmacokinetics of CYP Probe Drugs in Patients With Eosinophilic Esophagitis. [PDF]

Clin Transl Sci
ABSTRACT Cendakimab is a humanized monoclonal antibody that inhibits interleukin‐13 binding to its receptors. Although not expected to share clearance pathways with small molecules, its use in eosinophilic esophagitis, a type 2 inflammatory disease, may indirectly affect cytochrome P450 activity by modulating cytokine signaling affecting certain ...
Zhang P, Charriez CM, Murthy B, Basdeo S, Wang Y, Villa-Caballero L, Kandoussi H, De Oliveira CHMC, Leiman DA, Li J, Aras U.   +10 more
europepmc   +2 more sources

Impact of genetic and non-genetic factors on hepatic CYP2C9 expression and activity in Hungarian subjects

Scientific Reports, 2021
CYP2C9, one of the most abundant hepatic cytochrome P450 enzymes, is involved in metabolism of 15–20% of clinically important drugs (warfarin, sulfonylureas, phenytoin, non-steroid anti-inflammatory drugs).
Ferenc Fekete, Katalin Mangó, Máté Déri, Evelyn Incze, Annamária Minus, Katalin Monostory   +5 more
doaj   +1 more source

Clinical significance of the series of CYP2C9*non3 variants, an unignorable predictor of warfarin sensitivity in Chinese population

Frontiers in Cardiovascular Medicine, 2022
BackgroundsGene polymorphisms are critical for variations in warfarin dose. To date, more than 70 CYP2C9 alleles have been identified. This study was designed to clarify the clinical significance of CYP2C9*non-3 variants to warfarin sensitivity in ...
Dongxu Wang, Dongxu Wang, Hualan Wu, Min Dong, Qing Zhang, Anxu Zhao, Xinlong Zhao, Jia Chong, Minghui Du, Yan Wang, Haifeng Shi, Shuanghu Wang, Fang Wang, Jianping Cai, Jiefu Yang, Dapeng Dai, Hao Chen   +16 more
doaj   +1 more source

Functional characterization of the defective CYP2C9 variant CYP2C9*18

Pharmacology Research & Perspectives, 2021
Cytochrome P450 2C9 (CYP2C9) is one of the most important drugs metabolizing enzymes and accounts for the metabolism of about 13%–17% of clinical drugs.
Jian Liu, Hao Chen, Shuang‐Hu Wang, Quan Zhou, Pei‐Wu Geng, Yun‐Fang Zhou, Hua‐Lan Wu, Hai‐Feng Shi, Fang Wang, Jie‐Fu Yang, Jian‐Ping Cai, Da‐Peng Dai   +11 more
doaj   +1 more source

Association between CYP2C9 and CYP2C19 Polymorphism, Metabolism, and Neurotoxicity after Administration of Phenytoin: A Systematic Review

Keluwih, 2023
—Phenytoin is an antiepileptic drug (AED) metabolized by cytochrome P450 enzymes, especially by CYP2C9 (90%) and CYP2C19 (10%), where both enzymes are polymorphic so that they can undergo polymorphism and it can change the metabolic rate of the drug ...
Rizka Mardhiani, Yahdiana Harahap, Winnugroho Wiratman   +2 more
doaj   +1 more source