Results 21 to 30 of about 25,701 (209)

Functional characterization of the defective CYP2C9 variant CYP2C9*18

Pharmacology Research & Perspectives, 2021
Cytochrome P450 2C9 (CYP2C9) is one of the most important drugs metabolizing enzymes and accounts for the metabolism of about 13%–17% of clinical drugs.
Jian Liu, Hao Chen, Shuang‐Hu Wang, Quan Zhou, Pei‐Wu Geng, Yun‐Fang Zhou, Hua‐Lan Wu, Hai‐Feng Shi, Fang Wang, Jie‐Fu Yang, Jian‐Ping Cai, Da‐Peng Dai   +11 more
doaj   +1 more source

Association between CYP2C9 and CYP2C19 Polymorphism, Metabolism, and Neurotoxicity after Administration of Phenytoin: A Systematic Review

Keluwih, 2023
—Phenytoin is an antiepileptic drug (AED) metabolized by cytochrome P450 enzymes, especially by CYP2C9 (90%) and CYP2C19 (10%), where both enzymes are polymorphic so that they can undergo polymorphism and it can change the metabolic rate of the drug ...
Rizka Mardhiani, Yahdiana Harahap, Winnugroho Wiratman   +2 more
doaj   +1 more source

Genetic abnormality of cytochrome-P2C9*3 allele predisposes to epilepsy and phenytoin-induced adverse drug reactions: genotyping findings of cytochrome-alleles in the North Indian population

Future Journal of Pharmaceutical Sciences, 2022
Background This research aims to study the association of genetic polymorphism in genes coding for CYP2C9 and CYP2C19 in phenytoin-induced dose-related toxicity and to assess if the presence of allele CYP2C9*3 plays a role in phenytoin-induced ...
Vivek Kumar Garg, Supriya, Ritu Shree, Ajay Prakash, Aastha Takkar, Madhu Khullar, Biman Saikia, Bikash Medhi, Manish Modi   +8 more
doaj   +1 more source

Pharmacogenetics of sulfonylurea: Presence of CYP2C9*2, CYP2C9*3 and a novel allele, CYP2C9*61, in Type 2 diabetes patients under sulfonylurea therapy

Pakistan Journal of Pharmaceutical Sciences, 2020
CYP2C9 is an important member of the cytochrome P450 gene family involved in the metabolism of 15% of the drugs including an oral antidiabetic agent sulfonylurea.
Sumaira Deen Muhammad, Hazar Khan, Mushtaq Hussain, Tehseen Fatima Zeb, Darshan Kumar, Rahimullah Rahi, Mahayrookh Asif, Akhter Ali Balooch   +7 more
doaj   +1 more source

Pharmacogenomic implications of the differential distribution of CYP2C9 metabolic phenotypes among Latin American populations

Frontiers in Pharmacology, 2023
The CYP2C9 gene encodes the major drug metabolism enzyme CYP2C9. This gene is highly polymorphic, and no-function (CYP2C9*3) plus decreased function (CYP2C9*2, *5, *8 and *11) star alleles (haplotypes) are commonly used to predict CYP2C9 metabolic ...
Guilherme Suarez-Kurtz
doaj   +1 more source

Quantitative assessment of the effect of cytochrome P450 2C9 gene polymorphism and colorectal cancer. [PDF]

PLoS ONE, 2013
CYP2C9 enzyme activity is involved in the metabolism of substances related to colorectal cancer (CRC), and it is functionally linked to a genetic polymorphism.
Yuan Zhao, Yusong Han, Liang Zhang, Yichao Wang, Yushui Ma, Feng Zhang, Da Fu, Xiaofeng Wang   +7 more
doaj   +1 more source

ОСОБЕННОСТИ ВЗАИМОДЕЙСТВИЯ АЗОЛСОДЕРЖАЩИХ СОЕДИНЕНИЙ С ПОЛИМОРФНЫМИ ИЗОФОРМАМИ CYP2C9 [PDF]

, 2018
Azole-containing compounds are often co-administrated with different classes of medications, and are widely used as pesticides in agriculture. Besides the main action, azole-containing compounds can directly affect the human cytochrome P450 system ...
A. M. Tumilovich, A. A. Gilep, Т. А. Сушко, С. А. Усанов, И. В. Гайдукевич, S. A. Usanov, А. А. Гилеп, А. М. Тумилович, I. V. Haidukevich, T. A. Sushko   +9 more
core   +1 more source

Correlation analysis between CYP2C9 polymorphisms and liver injury induced by flurbiprofen axetil in 100 Han Chinese patients

Pakistan Journal of Pharmaceutical Sciences, 2023
This study explored correlation between CYP2C9 polymorphisms and liver injury induced by flurbiprofen axetil (FBA). A total of 100 patients undergoing primary total knee arthroplasty (TKA) were mainly administered with basic analgesic, FBA.
Jiecheng Xiao, Xianwei Wu, Chengfei Zhao
doaj   +1 more source

Study of the allelic variants CYP2C9*2 and CYP2C9*3 in the Peruvian mestizo population Estudio de las variantes alélicas CYP2C9*2 y CYP2C9*3 en población mestiza peruana [PDF]

, 2019
Introduction: CYP2C9 metabolizes approximately 15% of the prescribed drugs. Its gene has alleles whose frequencies differ between ethnic groups and populations.
Tito Alvarado, Ángel, Varela, Nelson Miguel, Alvarado, Ángel Tito, García, Jorge Antonio, Cerro, Roberto Andrés, Michiko Miyasato, Jessica, Muñoz, Ana María, Miyasato, Jessica Michiko, Muñoz Jauregui, Ana María, Varela Figueroa, Nelson Miguel, Loja, Berta, Quiñones, Luis Abel   +11 more
core   +1 more source

Comparison of CYP2C9 Activity in Ethiopian and Non-Ethiopian Jews Using Phenytoin as a Probe

Frontiers in Pharmacology, 2020
The pharmacokinetics of CYP2C9 substrates is characterized by substantial interethnic variability. The objective of the study was to compare CYP2C9 activity by using Phenytoin Metabolic Ratio (PMR) between Ethiopian and non-Ethiopian Jews.
Zahi Abu Ghosh, Shoshana Alamia, Chanan Shaul, Yoseph Caraco   +3 more
doaj   +1 more source