Results 21 to 30 of about 25,089 (208)

Correlation analysis between CYP2C9 polymorphisms and liver injury induced by flurbiprofen axetil in 100 Han Chinese patients

Pakistan Journal of Pharmaceutical Sciences, 2023
This study explored correlation between CYP2C9 polymorphisms and liver injury induced by flurbiprofen axetil (FBA). A total of 100 patients undergoing primary total knee arthroplasty (TKA) were mainly administered with basic analgesic, FBA.
Jiecheng Xiao, Xianwei Wu, Chengfei Zhao
doaj   +1 more source

Comparison of CYP2C9 Activity in Ethiopian and Non-Ethiopian Jews Using Phenytoin as a Probe

Frontiers in Pharmacology, 2020
The pharmacokinetics of CYP2C9 substrates is characterized by substantial interethnic variability. The objective of the study was to compare CYP2C9 activity by using Phenytoin Metabolic Ratio (PMR) between Ethiopian and non-Ethiopian Jews.
Zahi Abu Ghosh, Shoshana Alamia, Chanan Shaul, Yoseph Caraco   +3 more
doaj   +1 more source

Поліморфізм СYР2С9 у хворих із гострим болем у спині та його вплив на ефективність лікування нестероїдними протизапальними засобами

Львівський клінічний вісник, 2020
Вступ. Генетичні чинники можуть формувати різні варіанти фізіологічної відповіді на нестероїдні протизапальні засоби (НПЗЗ) – від повної неефективності до появи небажаних реакцій.
І. Г. Маслова, Н. О. Михайловська, Т. М. Слободін   +2 more
doaj   +1 more source

Effect of CYP2C9 on the migration, invasion and proliferation of hepatocellular carcinoma cells [PDF]

Yixue xinzhi zazhi
Objective To explore whether CYP2C9 is involved in the occurrence and development of hepatocellular carcinoma (HCC) and its function in the migration, invasion and proliferation of HCC cells.Methods The transcriptome data of HCC were retrieved from the ...
ZHANG Tuo, LI Dajun, WANG Haitao, ZHANG Peng   +3 more
doaj   +1 more source

Association of CYP2C9*2 Allele with Sulphonylurea-Induced Hypoglycaemia in Type 2 Diabetes Mellitus Patients: A Pharmacogenetic Study in Pakistani Pashtun Population

Biomedicines, 2023
Polymorphism in cytochrome P450 (CYP) 2C9 enzyme is known to cause significant inter-individual differences in drug response and occurrence of adverse drug reactions.
Asif Jan, Muhammad Saeed, Ramzi A. Mothana, Tahir Muhammad, Naveed Rahman, Abdullah R. Alanzi, Rani Akbar   +6 more
doaj   +1 more source

Study of the allelic variants CYP2C9*2 and CYP2C9*3 in the Peruvian mestizo population Estudio de las variantes alélicas CYP2C9*2 y CYP2C9*3 en población mestiza peruana [PDF]

, 2019
Introduction: CYP2C9 metabolizes approximately 15% of the prescribed drugs. Its gene has alleles whose frequencies differ between ethnic groups and populations.
Tito Alvarado, Ángel, Varela, Nelson Miguel, Alvarado, Ángel Tito, García, Jorge Antonio, Cerro, Roberto Andrés, Michiko Miyasato, Jessica, Muñoz, Ana María, Miyasato, Jessica Michiko, Muñoz Jauregui, Ana María, Varela Figueroa, Nelson Miguel, Loja, Berta, Quiñones, Luis Abel   +11 more
core   +1 more source

Frequency of CYP2C9 Promoter Variable Number Tandem Repeat Polymorphism in a Spanish Population: Linkage Disequilibrium with CYP2C9*3 Allele

, 2022
Background: A promoter variable number tandem repeat polymorphism (pVNTR) of CYP2C9 is described with three types of fragments: short (pVNTR-S), medium (pVNTR-M) and long (pVNTR-L). The pVNTR-S allele reduces the CYP2C9 mRNA level in the human liver, and
Miguel Ángel Suárez-Santisteban, Gutiérrez-Martín, Yolanda, Dorado, Pedro, Pedro Dorado, Santos-Díaz, Gracia, Yolanda Gutiérrez-Martín, Suárez-Santisteban, Miguel Ángel, Gracia Santos-Díaz   +7 more
core   +1 more source

Relevance of CYP2C9 Function in Valproate Therapy [PDF]

, 2018
Background:Genetic polymorphisms of drug metabolizing enzymes can substantially modify the pharmacokinetics of a drug and eventually its efficacy or toxicity; however, inferring a patient’s drug metabolizing capacity merely from his or her genotype can ...
Ádám Kiss, Katalin Tóth, Gábor Csukly, Tamás Bűdi, Andrea Nagy, Máté Déri, Katalin Monostory   +6 more
core   +2 more sources

Functional Characterisation of Human CYP2C9 Allelic Variants in COS-7 cells

Frontiers in Pharmacology, 2016
Variability in activity of CYP2C9, which is involved in the metabolism of approximately 15% of current therapeutic drugs, is an important contributor to interindividual differences in drug response.
Huihui eDu, Zhiyun eWei, Yucai eYan, Yuyu eXiong, Xiaoqing eZhang, Lu eShen, Yunfeng eRuan, Xi eWu, Qingqing eXu, Lin eHe, Shengying eQin   +10 more
doaj   +1 more source

Rational and safe dosing of phenprocoumon during loading and maintenance phase [PDF]

, 2012
Phenprocoumon is the second most commonly used oral anticoagulant worldwide and the most common agent in many European countries including Switzerland. Given its long half-life of about one week, an initial loading-dose is generally applied. A high
Caduff Good, Angela
core   +1 more source