Results 31 to 40 of about 25,089 (208)

Lack of Association of Clinical Factors (SAMe-TTR) with / Genotype and Anticoagulation Control Quality [PDF]

Journal of Stroke, 2015
Background and PurposeAdvantages of new oral anticoagulations may be greater in atrial fibrillation (AF) patients of poor anticoagulation control with warfarin.
Yun Kyung Park, Mi ji Lee, Jae Ha Kim, Suk Jae Kim, June Soo Kim, Soo-Youn Lee, Oh Young Bang   +6 more
doaj   +1 more source

CYP2C9 genotyping in clinical practice

, 2021
CYP2C9 jedan je od najvažnijih i najobilnije eksprimiranih enzima sustava citokrom P450 (CYP) u ljudskim jetrima. Odgovoran je za biotransformaciju oko 15 % klinički važnih lijekova, uključujući kumarinske antikoagulante (varfarin), antikonvulzive ...
Krsmanović, Dora
core   +1 more source

CYP2C9 polymorphisms are associated with phenytoin toxicity in South-Indian epileptic patients

Journal of Dr. NTR University of Health Sciences, 2020
Background and Aims: The contribution of CYP2C9 in phenytoin metabolism is generally modest, but it increases with increasing serum phenytoin concentration.
Rakesh Reddy Reddigari, S V Naveen Prasad, Vengamma Bhuma, P VGK Sarma, Appa Rao Anumolu   +4 more
doaj   +1 more source

Modulating effect of Cu(II) complexes with enamine and tetrazole derivatives on CYP2C and CYP3A and their cytotoxic and antiproliferative properties in HepG2 spheroids

Acta Biomedica Scientifica, 2022
CYP2C and CYP3A cytochromes are induced by a variety of compounds and affect the pharmacokinetics and pharmacodynamics of a large number of drugs. Currently, the possibility of using copper coordination compounds in antitumor therapy is being actively ...
L. S. Klyushova, Yu. A. Golubeva, V. A. Vavilin, A. Yu. Grishanova   +3 more
doaj   +1 more source

Mathematical modeling of pharmacokinetics and pharmacodynamics of losartan in relation to CYP2C9 allele variants

Frontiers in Systems Biology
Losartan is a selective angiotensin II AT1-receptor antagonist for the treatment of arterial hypertension and heart failure. It is converted to a pharmacologically active metabolite carboxylosartan (E-3174) in the liver mainly by CYP2C9 enzyme, a member ...
Dmitry Babaev, Elena Kutumova, Elena Kutumova, Fedor Kolpakov, Fedor Kolpakov   +4 more
doaj   +1 more source

AKR1D1*36 C>T (rs1872930) allelic variant is associated with variability of the CYP2C9 genotype predicted pharmacokinetics of ibuprofen enantiomers – a pilot study in healthy volunteers

Acta Pharmaceutica, 2019
The relative contribution of CYP2C9 allelic variants to the pharmacokinetics (PK) of ibuprofen (IBP) enantiomers has been studied extensively, but the potential clinical benefit of pharmacogenetically guided IBP treatment is not evident yet.
Kapedanovska Nestorovska Aleksandra, Jakjovski Krume, Naumovska Zorica, Sterjev Zoran, Geskovska Nadica Matevska, Mladenovska Kristina, Suturkova Ljubica, Dimovski Aleksandar   +7 more
doaj   +1 more source

Evaluation of the Influence of CYP2C9* 2, CYP2C9*3 Gene Polymorphisms on the Efficacy and Safety of Postoperative Analgesia with Ketoprofen in Patients after Cardiac Surgery

Рациональная фармакотерапия в кардиологии, 2021
Aim. The aim of the study was to evaluate the efficacy and safety of ketoprofen as an analgesic therapy in patients with CYP2C9*2 (430C>T) rs179985 and CYP2C9*3 (1075A>C) rs1057910 gene polymorphisms after cardiac surgery.Material and methods.
T. E. Morozova, D. A. Shatsky, N. V. Shikh, E. V. Shikh, T. B. Andrushchyshina, M. V. Lukina, A. A. Kachanova, Zh. A. Sozaeva, G. N. Shuev, N. P. Denisenko, E. A. Grishina, D. A. Sychev   +11 more
doaj   +1 more source

Does celecoxib inhibit agomelatine metabolism via CYP2C9 or CYP1A2?

, 2018
Umit Yasar Department of Medical Pharmacology, Hacettepe University, Faculty of Medicine, Ankara, TurkeyHe et al have reported inhibitory effect of celecoxib on agomelatine metabolism in rat/human liver microsomes, recombinant human cytochrome P450 (CYP)
Yasar U, Yasar, Umit
core   +1 more source

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source

Pharmacogenetics: Influence of CYP2C9*2 and *3 alleles polymorphisms on Iraqi type 2 diabetic patients

Medical Journal of Babylon
Background: Sulfonylureas (SUs) are the most prescribed anti-diabetic drugs. The enzyme responsible for metabolizing of SUs is hepatic cytochrome P4502C9 (CYP2C9).
Ghada S. Rasool, Asmaa A. Hussien, Suhad R. Al-Tayie, Salwa J. Al-Awadi, Hussein OM Al-Dahmoshi   +4 more
doaj   +1 more source