Results 11 to 20 of about 37,178 (276)

Functional characterization of the defective CYP2C9 variant CYP2C9*18 [PDF]

Pharmacology Research & Perspectives, 2021
Cytochrome P450 2C9 (CYP2C9) is one of the most important drugs metabolizing enzymes and accounts for the metabolism of about 13%–17% of clinical drugs.
Jian Liu, Hao Chen, Shuang‐Hu Wang, Quan Zhou, Pei‐Wu Geng, Yun‐Fang Zhou, Hua‐Lan Wu, Hai‐Feng Shi, Fang Wang, Jie‐Fu Yang, Jian‐Ping Cai, Da‐Peng Dai   +11 more
doaj   +3 more sources

PharmVar GeneFocus: CYP2C9 [PDF]

Clinical Pharmacology & Therapeutics, 2021
The Pharmacogene Variation Consortium (PharmVar) catalogues star (*) allele nomenclature for the polymorphic human CYP2C9 gene. Genetic variation within the CYP2C9 gene locus impacts the metabolism or bioactivation of many clinically important drugs, including nonsteroidal anti‐inflammatory drugs, phenytoin, antidiabetic agents, and angiotensin ...
Sangkuhl, Katrin, Claudio‐Campos, Karla, Cavallari, Larisa H., Agundez, Jose A.G., Whirl‐Carrillo, Michelle, Duconge, Jorge, Del Tredici, Andria L., Wadelius, Mia, Rodrigues Botton, Mariana, Woodahl, Erica L., Scott, Stuart A., Klein, Teri E., Pratt, Victoria M., Daly, Ann K., Gaedigk, Andrea   +14 more
openaire   +3 more sources

Metabolism and Metabolic Inhibition of Xanthotoxol in Human Liver Microsomes [PDF]

, 2016
Cytochrome p450 (CYP450) enzymes are predominantly involved in Phase I metabolism of xenobiotics. In this study, the CYP450 isoforms involved in xanthotoxol metabolism were identified using recombinant CYP450s.
Cai, Jiqun, Guo, Feng, Ma, Zhongnv, Shan, Lina, Shi, Xianbao, Zhang, Gang   +5 more
core   +17 more sources

Association between CYP2C9 and CYP2C19 Polymorphism, Metabolism, and Neurotoxicity after Administration of Phenytoin: A Systematic Review

Keluwih, 2023
—Phenytoin is an antiepileptic drug (AED) metabolized by cytochrome P450 enzymes, especially by CYP2C9 (90%) and CYP2C19 (10%), where both enzymes are polymorphic so that they can undergo polymorphism and it can change the metabolic rate of the drug ...
Rizka Mardhiani, Yahdiana Harahap, Winnugroho Wiratman   +2 more
doaj   +1 more source

Genetic abnormality of cytochrome-P2C9*3 allele predisposes to epilepsy and phenytoin-induced adverse drug reactions: genotyping findings of cytochrome-alleles in the North Indian population

Future Journal of Pharmaceutical Sciences, 2022
Background This research aims to study the association of genetic polymorphism in genes coding for CYP2C9 and CYP2C19 in phenytoin-induced dose-related toxicity and to assess if the presence of allele CYP2C9*3 plays a role in phenytoin-induced ...
Vivek Kumar Garg, Supriya, Ritu Shree, Ajay Prakash, Aastha Takkar, Madhu Khullar, Biman Saikia, Bikash Medhi, Manish Modi   +8 more
doaj   +1 more source

Pharmacogenomic implications of the differential distribution of CYP2C9 metabolic phenotypes among Latin American populations

Frontiers in Pharmacology, 2023
The CYP2C9 gene encodes the major drug metabolism enzyme CYP2C9. This gene is highly polymorphic, and no-function (CYP2C9*3) plus decreased function (CYP2C9*2, *5, *8 and *11) star alleles (haplotypes) are commonly used to predict CYP2C9 metabolic ...
Guilherme Suarez-Kurtz
doaj   +1 more source

Quantitative assessment of the effect of cytochrome P450 2C9 gene polymorphism and colorectal cancer. [PDF]

PLoS ONE, 2013
CYP2C9 enzyme activity is involved in the metabolism of substances related to colorectal cancer (CRC), and it is functionally linked to a genetic polymorphism.
Yuan Zhao, Yusong Han, Liang Zhang, Yichao Wang, Yushui Ma, Feng Zhang, Da Fu, Xiaofeng Wang   +7 more
doaj   +1 more source

Comparison of the TaqMan and LightCycler systems in pharmacogenetic testing: evaluation of the CYP2C9*2/*3 polymorphisms. [PDF]

, 2006
Background: Pharmacogenetic testing for drugmetabolizing enzymes is not yet widely used in clinical practice. Methods: In an attempt to facilitate the application of this procedure, we have compared two real-time PCRbased methods, the TaqMan_ and the ...
C. ESPOSITO, M. TORIELLO, MAZZACCARA, CRISTINA, P. MECCARIELLO, R. DI FIORE, SACCHETTI, LUCIA   +5 more
core   +1 more source

Genetic polymorphism of cytochrome p450 (2C19) enzyme in Iranian Turkman ethnic group [PDF]

, 2013
Objective: Different findings indicate that CYP2C plays a clinical role in determining interindividual and interethnic differences in drug effectiveness. The ethnic differences in the frequency of CYP2C19 mutant alleles continue to be a significant study
Ataby, O.A., Mansourian, A.R., Marjani, A., Samai, N.M., Tabari, R.G.   +4 more
core   +2 more sources

Pharmacogenetics of analgesic drugs [PDF]

, 2013
• Individual variability in pain perception and differences in the efficacy of analgesic drugs are complex phenomena and are partly genetically predetermined.
Branford, R, Cregg, R, Gubbay, A, Russo, G, Sato, H   +4 more
core   +1 more source