Results 11 to 20 of about 19,211 (198)
Frontiers in Pharmacology, 2023 The CYP2C9 gene encodes the major drug metabolism enzyme CYP2C9. This gene is highly polymorphic, and no-function (CYP2C9*3) plus decreased function (CYP2C9*2, *5, *8 and *11) star alleles (haplotypes) are commonly used to predict CYP2C9 metabolic ...
Guilherme Suarez-Kurtz
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Quantitative assessment of the effect of cytochrome P450 2C9 gene polymorphism and colorectal cancer. [PDF]
PLoS ONE, 2013 CYP2C9 enzyme activity is involved in the metabolism of substances related to colorectal cancer (CRC), and it is functionally linked to a genetic polymorphism.
Yuan Zhao +7 more
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Safety of Voriconazole in a Patient with CYP2C9*2/CYP2C9*2 Genotype [PDF]
Antimicrobial Agents and Chemotherapy, 2006 Voriconazole, a broad-spectrum triazole antifungal agent, is well absorbed, with a high oral bioavailability of 96% (6). Maximal plasma concentrations are observed 1 to 2 h after drug administration. The volume of distribution is estimated to be 4.6 liters/kg, and the plasma protein binding is 58%.
Marcus J P, Geist +3 more
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Estudio de las variantes alélicas CYP2C9*2 y CYP2C9*3 en muestras de población mestiza peruana
Biomédica: revista del Instituto Nacional de Salud, 2019 Introducción. El citocromo CYP2C9 metaboliza, aproximadamente, el 15 % de los fármacos prescritos. Su gen presenta alelos cuyas frecuencias difieren entre grupos étnicos y poblaciones. Los alelos CYP2C9*2 y CYP2C9*3 dan cuenta de una enzima con actividad
Ángel Tito Alvarado +7 more
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Pakistan Journal of Pharmaceutical Sciences, 2023 This study explored correlation between CYP2C9 polymorphisms and liver injury induced by flurbiprofen axetil (FBA). A total of 100 patients undergoing primary total knee arthroplasty (TKA) were mainly administered with basic analgesic, FBA.
Jiecheng Xiao, Xianwei Wu, Chengfei Zhao
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CYP2C9 polymorphisms and CYP2C9*2 genotyping primers [PDF]
British Journal of Clinical Pharmacology, 2002 The primers first suggested by Wang et al.[1] for the genotyping of the CYP2C9 Arg144Cys mutation were based on the gene structure of CYP2C9 prior to knowledge of the gene structure of the closely related CYP2C19. Early studies cannot be faulted for using these primers, since the gene structure of CYP2C19 was not known.
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Comparison of CYP2C9 Activity in Ethiopian and Non-Ethiopian Jews Using Phenytoin as a Probe
Frontiers in Pharmacology, 2020 The pharmacokinetics of CYP2C9 substrates is characterized by substantial interethnic variability. The objective of the study was to compare CYP2C9 activity by using Phenytoin Metabolic Ratio (PMR) between Ethiopian and non-Ethiopian Jews.
Zahi Abu Ghosh +3 more
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Львівський клінічний вісник, 2020 Вступ. Генетичні чинники можуть формувати різні варіанти фізіологічної відповіді на нестероїдні протизапальні засоби (НПЗЗ) – від повної неефективності до появи небажаних реакцій.
І. Г. Маслова +2 more
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CYP2C9 Genetic Polymorphisms and Warfarin [PDF]
Clinical and Applied Thrombosis/Hemostasis, 2004 The objective of this study was to report 2 cases of CYP2C9 genetic polymorphism and elevated warfarin S: R ratios in patients taking low doses of warfarin, and compare the observed characteristics with those in published reports. Two patients of different age groups and races were evaluated for CYP2C9 genotype and warfarin S: R ratios.
Andrea R, Redman +5 more
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Effect of CYP2C9 on the migration, invasion and proliferation of hepatocellular carcinoma cells [PDF]
Yixue xinzhi zazhiObjective To explore whether CYP2C9 is involved in the occurrence and development of hepatocellular carcinoma (HCC) and its function in the migration, invasion and proliferation of HCC cells.Methods The transcriptome data of HCC were retrieved from the ...
ZHANG Tuo +3 more
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