Exposure to CYP3A4‐inducing and CYP3A4‐non‐inducing antiepileptic agents and the risk of fractures [PDF]
Pharmacoepidemiology and Drug Safety, 2011 ABSTRACTPurposeTo evaluate whether exposure to Cytochrome P450, family 3, subfamily A, polypeptide 4 (CYP3A4)‐inducing antiepileptics increases fracture risk compared to CYP3A4‐non‐inducing antiepileptics.MethodsWe performed a retrospective cohort study of initiators of antiepileptic agents using a UK medical record database (The Health Improvement ...
Hedi, Schelleman +6 more
openaire +2 more sources
Pharmacokinetic Herb-Drug Interactions: Insight into Mechanisms and Consequences [PDF]
, 2015 Herbal medicines are currently in high demand, and their popularity is steadily increasing. Because of their perceived effectiveness, fewer side effects and relatively low cost, they are being used for the management of numerous medical conditions ...
Horie, Toshiharu +3 more
core +1 more source
Three new shRNA expression vectors targeting the CYP3A4 coding sequence to inhibit its expression
Acta Pharmaceutica Sinica B, 2014 RNA interference (RNAi) is useful for selective gene silencing. Cytochrome P450 3A4 (CYP3A4), which metabolizes approximately 50% of drugs in clinical use, plays an important role in drug metabolism. In this study, we aimed to develop a short hairpin RNA
Siyun Xu +6 more
doaj +1 more source
ASM Science Journal, 2022 The cytochrome P450 (CYP) enzymes are of a ubiquitous heme–thiolate proteins family that plays an important role within the biotransformation of endogenous molecules and xenobiotics as today’s market is bio-transformed through CYP-mediated metabolism ...
Fazleen Haslinda Mohd Hatta +4 more
doaj +1 more source
Simulated microgravity promotes the formation of tridimensional cultures and stimulates pluripotency and a glycolytic metabolism in human hepatic and biliary tree stem/progenitor cells [PDF]
, 2019 Many pivotal biological cell processes are affected by gravity. The aim of our study was to evaluate biological and functional effects, differentiation potential and exo-metabolome profile of simulated microgravity (SMG) on human hepatic cell line (HepG2)
Alvaro, Domenico +14 more
core +2 more sources
Effect of verapamil on the pharmacokinetics of hydroxycamptothecin and its potential mechanism
Pharmaceutical Biology, 2020 Context Hydroxycamptothecin (HCPT) has antitumor activity in various cancers, but its poor bioavailability and efflux limit its clinical application. Verapamil has been demonstrated to improve the bioavailability of many drugs.
Hua Xing +6 more
doaj +1 more source
Assessment of extracts from red yeast rice for herb-drug interaction by in-vitro and in-vivo assays [PDF]
, 2012 Red yeast rice (RYR) is made by fermenting the yeast Monascus purpureus over rice. It is a source of natural red food colorants, a food garnish and a traditional medication.
Fung, W.T. +4 more
core +2 more sources
No association of a set of candidate genes on haloperidol side effects. [PDF]
, 2012 We previously investigated a sample of patients during an active phase of psychosis in the search for genetic predictors of haloperidol induced side effects.
De Ronchi, Diana +8 more
core +4 more sources
Genetic diversity of and polymorphisms in North African populations from Morocco and Tunisia
The International Journal of Biological Markers, 2015 The genes CYP3A4 and CYP3A5 form part of a cluster of cytochrome P450 genes involved in drug metabolism reactions. The allelic variants of these genes CYP3A4*1B, CYP3A4*3, CYP3A4*17 and CYP3A5*3 have been linked both to the reduced catalytic activity of ...
Apolonia Novillo +7 more
doaj +1 more source
Direct Acting Antiviral Drugs: Pharmacokinetics and Drug-Drug Interactions
Archives of Pharmaceutical Sciences Ain Shams University, 2022 Hepatitis C (HCV) is a widespread health issue, which can lead to hepatic cirrhosis, liver failure, and liver cancer. Nearly 2% of the world's population or > 185 million people are chronically infected with HCV; the management of HCV and the rate of ...
Marina Barakat +3 more
doaj +1 more source