Journal of Pharmacological Sciences, 2004 A relatively large amount of human liver tissue was required to determine the exact activity of human hepatic CYP3A. Although, the quantity of available human liver tissue samples is limited.
Minoru Watanabe +6 more
doaj +5 more sources
CYP3A4 and CYP3A5genotyping by Pyrosequencing [PDF]
BMC Medical Genetics, 2005 Human cytochrome P450 3A enzymes, particularly CYP3A4 and CYP3A5, play an important role in drug metabolism. CYP3A expression exhibits substantial interindividual variation, much of which may result from genetic variation. This study describes Pyrosequencing assays for key SNPs in CYP3A4 (CYP3A4*1B, CYP3A4*2, and CYP3A4*3) and CYP3A5 (CYP3A5*3C and ...
McLeod Howard L +2 more
openaire +5 more sources
A Novel Multiplex PCR-RFLP Method for Simultaneous Genotyping of CYP3A4*4 A>G, CYP3A4*18B G>A and CYP3A4*22 C>T [PDF]
Malaysian Journal of Medical Sciences, 2018 Cytochrome P450 3A enzymes exhibit a variety of physiological roles and have been reported to be the most predominant enzymes involved in drugs metabolism. Single nucleotide polymorphisms (SNPs) in the genes that code for these enzymes may result in functional changes that affect enzyme activity.
Abubakar, Murtala Bello +2 more
core +5 more sources
Functional assessment of CYP3A4 allelic variants on lidocaine metabolism in vitro
Drug Design, Development and Therapy, 2017 Ping Fang,1 Peng-fei Tang,1 Ren-ai Xu,2 Xiang Zheng,1 Jian Wen,1 Su-su Bao,1 Jian-ping Cai,3 Guo-xin Hu1 1Department of Pharmacology, School of Pharmacy, Wenzhou Medical University, 2Department of Pharmacy, The First Affiliated Hospital of Wenzhou ...
Fang P +7 more
doaj +1 more source
Genetic diversity of and polymorphisms in North African populations from Morocco and Tunisia
The International Journal of Biological Markers, 2015 The genes CYP3A4 and CYP3A5 form part of a cluster of cytochrome P450 genes involved in drug metabolism reactions. The allelic variants of these genes CYP3A4*1B, CYP3A4*3, CYP3A4*17 and CYP3A5*3 have been linked both to the reduced catalytic activity of ...
Apolonia Novillo +7 more
doaj +2 more sources
Three new shRNA expression vectors targeting the CYP3A4 coding sequence to inhibit its expression [PDF]
Acta Pharmaceutica Sinica B, 2014 RNA interference (RNAi) is useful for selective gene silencing. Cytochrome P450 3A4 (CYP3A4), which metabolizes approximately 50% of drugs in clinical use, plays an important role in drug metabolism. In this study, we aimed to develop a short hairpin RNA
Siyun Xu +6 more
doaj +2 more sources
CYP3A4*20, CYP3A4*22, CYP2C8*3 and SLCO1B1 as genetic biomarkers to predict peripheral neuropathy induced by paclitaxel and docetaxel: A systematic review [PDF]
Journal of Pharmacy & Pharmacognosy ResearchContext: Cancer is a global health problem with a growing incidence year after year, and it is projected that by 2040, there will be more than 2.4 million cases in Latin America and the Caribbean, being the second cause of death in these countries.
Angel T. Alvarado +16 more
doaj +2 more sources
CYP3A4*22: Promising Newly IdentifiedCYP3A4Variant Allele for Personalizing Pharmacotherapy
Pharmacogenomics, 2012 Many studies have attempted to explain the interindividual variability observed in drug metabolism by assessing the impact of SNPs in genes implicated in drug absorption, distribution, metabolism and excretion pathways. Particular attention has been paid to the CYP450s.
Elens, Laure +4 more
openaire +4 more sources
Alflutinib (AST2818), primarily metabolized by CYP3A4, is a potent CYP3A4 inducer [PDF]
Acta Pharmacologica Sinica, 2020 Alflutinib (AST2818) is a third-generation epidermal growth factor receptor (EGFR) inhibitor that inhibits both EGFR-sensitive mutations and T790M mutations. Previous study has shown that after multiple dosages, alflutinib exhibits nonlinear pharmacokinetics and displays a time- and dose-dependent increase in the apparent clearance, probably due to its
Liu, Xiao-yun +8 more
openaire +2 more sources
Patients with Chronic Inflammatory Diseases Can Experience Higher Exposure of Small Molecule Drugs than Healthy Volunteers: An Analysis of Recently Approved Drugs. [PDF]
Clin Pharmacol TherChronic inflammation has long been known to downregulate the activity of certain cytochrome P450 (CYP) enzymes—the main enzymes responsible for the phase I metabolism of many small molecule drugs—potentially leading to higher exposures in patients with chronic inflammatory diseases compared to healthy volunteers. Neglecting this potential difference in
Tillil J +6 more
europepmc +2 more sources