Results 11 to 20 of about 43,637 (267)
In vitro inhibitory effects of ganoderic acid A on human liver cytochrome P450 enzymes
Pharmaceutical Biology, 2020 Context Ganoderic acid A (GAA) is usually used to prevent cancers or other diseases, which make it likely to be used with other drugs metabolized by cytochromes P450.
Shangchen Xu +5 more
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Influence of quercetin and chrysin on the intestinal permeability of paclitaxel, a substrate of P-glycoprotein and CYP3A4 using in vitro rat gut sacs [PDF]
Trends in Pharmaceutical Sciences, 2019 P-glycoprotein (P-gp) and cytochrome P450 3A4 (CYP3A4) play a significant role in the disposition and elimination of drugs. The objective of this study was to investigate the mechanism underlying the interaction between paclitaxel (substrate of P-gp and ...
Ravindra Babu Pingili +3 more
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SLCO1B1 and CYP3A4 allelic variants associated with pharmacokinetic interactions and adverse reactions induced by simvastatin and atorvastatin used in Peru: Clinical implications [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2023 Context: Statins reduce the risk of stroke and prevent cardiac events in people with atherosclerosis and diabetes mellitus; and could affect the proliferation, migration, and survival of cancer cells.
Angel T. Alvarado +16 more
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Pharmaceutical Biology, 2020 Context Ligustrazine and valsartan are commonly used drugs in the treatment of cardiac and cardiovascular disease. Objective The interaction between ligustrazine and valsartan was studied to investigate the effect of ligustrazine on the pharmacokinetics ...
Yang Liu, Jiaqi Zhang, Di Wu, Liran Cui
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Lipid Drug Carriers for Cancer Therapeutics: An Insight into Lymphatic Targeting, P-gp, CYP3A4 Modulation and Bioavailability Enhancement [PDF]
Advanced Pharmaceutical Bulletin, 2020 In the treatment of cancer, chemotherapy plays an important role though the efficacy of anti-cancer drug administered orally is limited, due to their poor solubility in physiological medium, inability to cross biological membrane, high Para-glycoprotein (
Shashank Chaturvedi +2 more
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Imidazopyridines as selective CYP3A4 inhibitors [PDF]
Bioorganic & Medicinal Chemistry Letters, 2012 Cytochrome P450s are the major family of enzymes responsible for the oxidative metabolism of pharmaceuticals and xenobiotics. CYP3A4 and CYP3A5 have been shown to have overlapping substrate and inhibitor profiles and their inhibition has been demonstrated to be involved in numerous pharmacokinetic drug-drug interactions. Here we report the first highly
Xinyi, Song +6 more
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In vitro inhibitory effects of dihydromyricetin on human liver cytochrome P450 enzymes
Pharmaceutical Biology, 2017 Context: Dihydromyricetin (DHM) is the most abundant and active flavonoid component isolated from Ampelopsis grossedentata (Hand-Mazz) W.T. Wang (Vitaceae) and it possesses numerous pharmacological activities. However, whether DHM affects the activity of
Lu Liu +3 more
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Nanotechnology Reviews, 2017 Piperine helps in the improvement of bioavailability through pharmacokinetic interaction by modulating metabolism when administered with other drugs. Nisoldipine is a substrate for cytochrome P4503A4 enzymes.
Rathee Permender +2 more
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In vitro inhibitory effects of cepharanthine on human liver cytochrome P450 enzymes
Pharmaceutical Biology, 2020 Context Cepharanthine (CEP) extracted from the roots of Stephania cepharantha Hayata (Menispermaceae), has a range of therapeutic potential in clinical conditions.
Xunge Zhang +5 more
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Hepatology Communications, 2021 In drug development, a system for predicting drug metabolism and drug‐induced toxicity is necessary to ensure drug safety. Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) is an important drug‐metabolizing enzyme expressed in the liver and small ...
Sayaka Deguchi +8 more
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