Results 21 to 30 of about 26,813 (237)

Low ABCB1 gene expression is an early event in colorectal carcinogenesis. [PDF]

PLoS ONE, 2013
The ABCB1/MDR1 gene product ABCB1/P-glycoprotein is implicated in the development of colorectal cancer (CRC). NFKB1 encodes transcription factors regulating expression of a number of genes including ABCB1. We have previously found association between the
Vibeke Andersen, Ulla Vogel, Sine Godiksen, Franz B Frenzel, Mona Sæbø, Julian Hamfjord, Elin Kure, Lotte K Vogel   +7 more
doaj   +1 more source

The Resistance of Cancer Cells to Palbociclib, a Cyclin-Dependent Kinase 4/6 Inhibitor, is Mediated by the ABCB1 Transporter

Frontiers in Pharmacology, 2022
Palbociclib was approved by the United States Food and Drug Administration for use, in combination with letrozole, as a first-line treatment for estrogen receptor-positive/human epidermal growth factor receptor 2-negative (ER+/HER2-) postmenopausal ...
Han Fu, Zhuo-Xun Wu, Zi-Ning Lei, Zi-Ning Lei, Qiu-Xu Teng, Yuqi Yang, Charles R. Ashby, Yixiong Lei, Yuyin Lian, Zhe-Sheng Chen   +9 more
doaj   +1 more source

Mechanism of multidrug recognition by MDR1/ABCB1 [PDF]

Cancer Science, 2007
MDR1/ABCB1, a member of the ABC group of proteins, is clinically important because it is not only involved in multidrug resistance in cancer but also affects the pharmacokinetic properties of various drugs. The most puzzling feature of MDR1 is that it recognizes and transports such a wide variety of substrates.
Yasuhisa, Kimura, Shin-ya, Morita, Michinori, Matsuo, Kazumitsu, Ueda   +3 more
openaire   +2 more sources

Clinical significance of ABCB1 genotyping in oncology [PDF]

Journal of Oncology Pharmacy Practice, 2009
Background. P-glycoprotein (Pgp) is a drug efflux pump that transports natural products, including taxanes and other chemotherapeutic agents, from cells. Several frequent polymorphisms in ATP binding cassette gene B1 (ABCB1) may influence Pgp levels and drug efflux.
Alma, Hamidovic, Kristine, Hahn, Jill, Kolesar   +2 more
openaire   +2 more sources

Targeted nanopore sequencing for the identification of ABCB1 promoter translocations in cancer

BMC Cancer, 2020
Background Resistance to chemotherapy is the most common cause of treatment failure in acute myeloid leukemia (AML) and the drug efflux pump ABCB1 is a critical mediator.
Mark S. Williams, Naseer J. Basma, Fabio M. R. Amaral, Gillian Williams, John P. Weightman, Wolfgang Breitwieser, Louisa Nelson, Stephen S. Taylor, Daniel H. Wiseman, Tim C. P. Somervaille   +9 more
doaj   +1 more source

Purvalanol A, olomoucine II and roscovitine inhibit ABCB1 transporter and synergistically potentiate cytotoxic effects of daunorubicin in vitro. [PDF]

PLoS ONE, 2013
Cyclin-dependent kinase inhibitors (CDKi) have high potential applicability in anticancer therapy, but various aspects of their pharmacokinetics, especially their interactions with drug efflux transporters, have not yet been evaluated in detail. Thus, we
Daniela Cihalova, Jakub Hofman, Martina Ceckova, Frantisek Staud   +3 more
doaj   +1 more source

Importance of Ethnicity, CYP2B6 and ABCB1 Genotype for Efavirenz Pharmacokinetics and Treatment Outcomes: A Parallel-group Prospective Cohort Study in two sub-Saharan Africa Populations. [PDF]

, 2013
We evaluated the importance of ethnicity and pharmacogenetic variations in determining efavirenz pharmacokinetics, auto-induction and immunological outcomes in two African populations. ART naïve HIV patients from Ethiopia (n = 285) and Tanzania (n = 209)
Makonnen, Eyasu, Ngaimisi, E, Klaus-Dieter Riedel, Habtewold, A, Burhenne Juergen, Mugusi, F, Mugusi Sabina, Janabi, M, Omary Minzi, Mugusi Ferdinand, Getachew Aderaye, Makonnen, E, Mohammed Janabi, Yimer Getnet, Yimer, G, Eleni Aklillu, Habtewold Abiy, Minzi Omary, Minzi, O, Mugusi, S, Riedel Klaus-Dieter, Ngaimisi Eliford, Aderaye, G, Ferdinand Mugusi, Mugusi, Ferdinand, Abiy Habtewold, Habtewold, A., Aklillu Eleni, Wondwossen Amogne, Amogne, W, Ngaimisi, E.,, Ngaimisi, Eliford, Amogne Wondwossen, Aderaye, Getachew, Minzi, Omary, Aderaye Getachew, Bertilsso, L, Makonnen Eyasu, Habtewold, Abiy, Riedel, K, Eliford Ngaimisi, Bertilsson, Leif, Mugusi, Sabina, Amogne, W., Riedel, Klaus-Dieter, Makonnen, E., Juergen Burhenne, Yimer, Getnet, Aklillu, E, Amogne, Wondwossen, Bertilsson Leif, Burhenne, J, Leif Bertilsson, Eyasu Makonnen, Burhenne, Juergen, Mugusi, S., Janabi, Mohammed, Aklillu, Eleni, Janabi Mohammed, Bertilsson, L, Sabina Mugusi, Getnet Yimer, Minzi, O.   +62 more
core   +1 more source

The ABCB1 transporter gene and antidepressant response [PDF]

F1000 Biology Reports, 2009
P-glycoprotein, encoded by the ABCB1 gene, may modulate the brain concentration of several antidepressants. Functional genetic variation is thought to exist in this gene, and here we review several studies that have attempted to associate this variation with clinical response to antidepressant treatment.
Peters, Eric J, Reus, Victor, Hamilton, Steven P   +2 more
openaire   +4 more sources

Effect of four ABCB1 genetic polymorphisms on the accumulation of darunavir in HEK293 recombinant cell lines

Scientific Reports, 2021
The intracellular penetration of darunavir, a second-generation HIV protease inhibitor, is limited by the activity of the efflux P-glycoprotein (ABCB1).
Gabriel Stillemans, Happy Phanio Djokoto, Kévin-Alexandre Delongie, Halima El-Hamdaoui, Nadtha Panin, Vincent Haufroid, Laure Elens   +6 more
doaj   +1 more source

Effect of polymorphisms in CYP3A4*22 (rs35599367) C>T, CYP3A5*3 (rs776746) A>G, ABCB1 (rs4148738) C>T and ABCB1 (rs1045642) C>T genes on apixaban anticoagulation: pilot study results

Медицинский совет, 2021
Introduction. Apixaban is a direct oral anticoagulant prescribed for treatment and prevention of venous thromboembolism (VTE) and for prevention of stroke in patients with nonvalvular atrial fibrillation.
I. N. Sychev, L. V. Fedina, A. S. Osipov, I. I. Temirbulatov, O. Yu. Tataroy, Zh. A. Sozaeva, K. A. Akmalova, N. P. Denisenko, S. P. Abdullaev, A. A. Kachanova, E. A. Grishina, K. B. Mirzaev, D. A. Sychev   +12 more
doaj   +1 more source