Results 21 to 30 of about 29,397 (197)

Transcriptomic Profiling of SLC and ABC Transporters in the Human Term Placenta. [PDF]

Clin Pharmacol Ther
Solute carriers (SLC) and ATP‐binding cassette (ABC) transporters are essential for placental solute exchange and fetal protection, yet their transcriptomic profiles in the human placenta remain poorly characterized. Although fetal sex influences placental development and function, its impact on transporter expression is unclear.
Jung EM, Ieronimakis N, Mousa B, Sheikh ED, Ligon SE, Monson JW, Damicis JR, Kinsman HJ, Bettridge LE, Arnold SLM, Kelly EJ, Unadkat JD, Wang J.   +12 more
europepmc   +2 more sources

Elevated ABCB1 Expression Confers Acquired Resistance to Aurora Kinase Inhibitor GSK-1070916 in Cancer Cells

Frontiers in Pharmacology, 2021
The emergence of multidrug resistance (MDR) has been a major issue for effective cancer chemotherapy as well as targeted therapy. One prominent factor that causes MDR is the overexpression of ABCB1 transporter.
Zhuo-Xun Wu, Yuqi Yang, Jing-Quan Wang, Wen-Min Zhou, Junyu Chen, Yi-Ge Fu, Ketankumar Patel, Zhe-Sheng Chen, Jian-Ye Zhang   +8 more
doaj   +1 more source

Effect of four ABCB1 genetic polymorphisms on the accumulation of darunavir in HEK293 recombinant cell lines

Scientific Reports, 2021
The intracellular penetration of darunavir, a second-generation HIV protease inhibitor, is limited by the activity of the efflux P-glycoprotein (ABCB1).
Gabriel Stillemans, Happy Phanio Djokoto, Kévin-Alexandre Delongie, Halima El-Hamdaoui, Nadtha Panin, Vincent Haufroid, Laure Elens   +6 more
doaj   +1 more source

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

Effect of polymorphisms in CYP3A4*22 (rs35599367) C>T, CYP3A5*3 (rs776746) A>G, ABCB1 (rs4148738) C>T and ABCB1 (rs1045642) C>T genes on apixaban anticoagulation: pilot study results

Медицинский совет, 2021
Introduction. Apixaban is a direct oral anticoagulant prescribed for treatment and prevention of venous thromboembolism (VTE) and for prevention of stroke in patients with nonvalvular atrial fibrillation.
I. N. Sychev, L. V. Fedina, A. S. Osipov, I. I. Temirbulatov, O. Yu. Tataroy, Zh. A. Sozaeva, K. A. Akmalova, N. P. Denisenko, S. P. Abdullaev, A. A. Kachanova, E. A. Grishina, K. B. Mirzaev, D. A. Sychev   +12 more
doaj   +1 more source

Validation of a simple genotyping panel assay for pharmacogenomics of taxane-based therapy: preliminary results [PDF]

World Cancer Research Journal, 2023
Objective: Several strategies for preventing toxicity and resistance to taxane-based chemotherapy have been investigated so far. Lately, findings on the genetic variants associated with neutropenia and neuropathy (N&N) toxicity have been reported ...
A. Vitale, L. Di Francia, D. Costagliola, M. Mignano, A. Luise, M. Di Paolo, S. Pugliese, V. De Lucia, E. Varriale, R. Di Francia   +9 more
doaj   +1 more source

The Impact of ABCB1 and CES1 Polymorphisms on Dabigatran Pharmacokinetics in Healthy Chinese Subjects

Pharmacogenomics and Personalized Medicine, 2021
Yue Liu,1,* Chenguang Yang,2,* Wenyuan Qi,1 Zuowei Pei,2 Wei Xue,1 Huolan Zhu,2 Min Dong,2 Ying Guo,2 Duanduan Cong,1 Fang Wang2 1Clinical Trial Center, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Science ...
Liu Y, Yang C, Qi W, Pei Z, Xue W, Zhu H, Dong M, Guo Y, Cong D, Wang F   +9 more
doaj  

Bruton’s Tyrosine Kinase (BTK) Inhibitor RN486 Overcomes ABCB1-Mediated Multidrug Resistance in Cancer Cells

Frontiers in Cell and Developmental Biology, 2020
Overexpression of ATP-binding cassette subfamily B member 1 (ABCB1) remains one of the most vital factors leading to multidrug resistance (MDR). It is important to enhance the effect and bioavailability of chemotherapeutic drugs that are substrates of ...
Xing-Duo Dong, Meng Zhang, Meng Zhang, Xiubin Ma, Jing-Quan Wang, Zi-Ning Lei, Qiu-Xu Teng, Yi-Dong Li, Lusheng Lin, Weiguo Feng, Weiguo Feng, Zhe-Sheng Chen   +11 more
doaj   +1 more source

ABCB1 limits the cytotoxic activity of TAK-243, an inhibitor of the ubiquitin-activating enzyme UBA1

Frontiers in Bioscience-Landmark, 2022
Background: One of the major concerns of cancer therapy is the emergence of multidrug resistance (MDR). The MDR-associated ATP-binding cassette sub-family B member 1 (ABCB1) transporter is established to mediate resistance against numerous anticancer ...
Zhuoxun Wu, Yuqi Yang, Zining Lei, Silpa Narayanan, Jingquan Wang, Qiuxu Teng, Megumi Murakami, Suresh V. Ambudkar, Fengfeng Ping, Zhesheng Chen   +9 more
doaj   +1 more source

Antiproliferative and cytotoxic activities of furocoumarins of Ducrosia anethifolia

Pharmaceutical Biology, 2018
Context: Phytochemical and pharmacological data on Ducrosia anethifolia (DC.) Boiss. (Apiaceae), an Iranian medicinal plant, are scarce; however, furocoumarins are characteristic compounds of D. anethifolia.
Javad Mottaghipisheh, Márta Nové, Gabriella Spengler, Norbert Kúsz, Judit Hohmann, Dezső Csupor   +5 more
doaj   +1 more source