Results 21 to 30 of about 21,197 (211)
The ABCB1 transporter gene and antidepressant response [PDF]
F1000 Biology Reports, 2009 P-glycoprotein, encoded by the ABCB1 gene, may modulate the brain concentration of several antidepressants. Functional genetic variation is thought to exist in this gene, and here we review several studies that have attempted to associate this variation with clinical response to antidepressant treatment.
Peters, Eric J +2 more
openaire +4 more sources
Scientific Reports, 2021 The intracellular penetration of darunavir, a second-generation HIV protease inhibitor, is limited by the activity of the efflux P-glycoprotein (ABCB1).
Gabriel Stillemans +6 more
doaj +1 more source
Медицинский совет, 2021 Introduction. Apixaban is a direct oral anticoagulant prescribed for treatment and prevention of venous thromboembolism (VTE) and for prevention of stroke in patients with nonvalvular atrial fibrillation.
I. N. Sychev +12 more
doaj +1 more source
ABCB1 limits the cytotoxic activity of TAK-243, an inhibitor of the ubiquitin-activating enzyme UBA1
Frontiers in Bioscience-Landmark, 2022 Background: One of the major concerns of cancer therapy is the emergence of multidrug resistance (MDR). The MDR-associated ATP-binding cassette sub-family B member 1 (ABCB1) transporter is established to mediate resistance against numerous anticancer ...
Zhuoxun Wu +9 more
doaj +1 more source
Pharmacogenomics and Personalized Medicine, 2021 Yue Liu,1,* Chenguang Yang,2,* Wenyuan Qi,1 Zuowei Pei,2 Wei Xue,1 Huolan Zhu,2 Min Dong,2 Ying Guo,2 Duanduan Cong,1 Fang Wang2 1Clinical Trial Center, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Science ...
Liu Y +9 more
doaj
Frontiers in Cell and Developmental Biology, 2020 Overexpression of ATP-binding cassette subfamily B member 1 (ABCB1) remains one of the most vital factors leading to multidrug resistance (MDR). It is important to enhance the effect and bioavailability of chemotherapeutic drugs that are substrates of ...
Xing-Duo Dong +11 more
doaj +1 more source
Validation of a simple genotyping panel assay for pharmacogenomics of taxane-based therapy: preliminary results [PDF]
World Cancer Research Journal, 2023 Objective: Several strategies for preventing toxicity and resistance to taxane-based chemotherapy have been investigated so far. Lately, findings on the genetic variants associated with neutropenia and neuropathy (N&N) toxicity have been reported ...
A. Vitale +9 more
doaj +1 more source
Antiproliferative and cytotoxic activities of furocoumarins of Ducrosia anethifolia
Pharmaceutical Biology, 2018 Context: Phytochemical and pharmacological data on Ducrosia anethifolia (DC.) Boiss. (Apiaceae), an Iranian medicinal plant, are scarce; however, furocoumarins are characteristic compounds of D. anethifolia.
Javad Mottaghipisheh +5 more
doaj +1 more source
Erdafitinib Antagonizes ABCB1-Mediated Multidrug Resistance in Cancer Cells
Frontiers in Oncology, 2020 ABCB1 overexpression is known to contribute to multidrug resistance (MDR) in cancers. Therefore, it is critical to find effective drugs to target ABCB1 and overcome MDR.
Weiguo Feng +12 more
doaj +1 more source
Use of photoimmunoconjugates to characterize ABCB1 in cancer cells
Nanophotonics, 2021 Abstract Accurate detection of ATP‐binding cassette drug transporter ABCB1 expression is imperative for precise identification of drug‐resistant tumors. Existing detection methods fail to provide the necessary molecular details regarding the functional state of the transporter.
Barry J. Liang +3 more
openaire +4 more sources